With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27646-80-6, name is 2-Methyl-2-(methylamino)propan-1-ol, molecular formula is C5H13NO, molecular weight is 103.17, as common compound, the synthetic route is as follows.Recommanded Product: 2-Methyl-2-(methylamino)propan-1-ol
D16(a) 2-((2,6-dichloropyrimidin-4-yl)(methyl)amino)-2-methylpropan-l-ol 2-methyl-2-(methylamino)propan-l-ol (6.5 g, 63.0 mmol) in acetonitrile (50 mL) was added dropwise to solution of 2,4,6-trichloropyrimidine (11.56 g, 63.0 mmol) and triethylamine (8.78 mL, 63.0 mmol) in acetonitrile (100 mL) at 0 °C with stirring. The reaction mixture was stirred at 25 °C for 6 h, and then concentrated. EtOAc (20 mL) was then added. The organic phase was washed with water, brine, dried over sodium sulphate, and concentrated in vacuo. The residue was purified by silica gel column (PE/EA 5/1 to 3/1) to afford the title compound (2.5 g, 15.9percent) as a yellow solid. LC-MS (ESI): m/z 250 [M + H]+; 0.95 min (ret time).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,27646-80-6, 2-Methyl-2-(methylamino)propan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; SANG, Yingxia; WAN, Zehong; ZHANG, Qing; WO2014/114694; (2014); A1;,
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