Category: 1051899-73-0

Extracurricular laboratory: Synthetic route of 1051899-73-0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Synthetic Route of 1051899-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1051899-73-0, name is (3-Amino-2-fluorophenyl)methanol, molecular formula is C7H8FNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 102: ethyl [2-fluoro-3-(hydroxymethyl)phenyl]carbamate A stirred suspension of sodium carbonate (78 mg, 1.573 mmol) and Intermediate 101 (222 mg, 1.573 mmol) in 10 mL of water was cooled at 0 C. under nitrogen atmosphere. Ethyl chlorocarbonate (ALDRICH, 171 mg, 1.573 mmol) was added dropwise. Reaction was stirred for 1 h 30 min at 0 C. and then allowed to reach room temperature. Crude of reaction was partitioned with Et2O. Organic layers were dried with MgSO4 (anh), filtered and concentrated to obtain the title compound (359 mg, 1.600 mmol, quantitative yield). 1H NMR (300 MHz, DMSO-d6) 8 ppm: 9.21 (br s, 1H), 7.45-7.55 (m, 1H), 7.05-7.22 (m, 2H), 5.24 (br s, 1H), 4.51 (s, 2H), 4.10 (q, 2H), 1.22 (t, 3H). [ES+MS] m/z 214 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Reference:
Patent; Ballell Pages, Lluis; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Leon Diaz, Maria Luisa; Mendoza Losana, Alfonso; Wolfendale, Matthew James; US2012/95064; (2012); A1;,
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Alcohols – Chemistry LibreTexts

The origin of a common compound about (3-Amino-2-fluorophenyl)methanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Application of 1051899-73-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1051899-73-0, name is (3-Amino-2-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2,4-dichloropyrimidine (300 mg, 2.01 mmol), (3-amino-2- fluorophenyl)methanol (256 mg, 1.81 mmol) and triethylamine (309 mul, 2.22 mmol) in 2- propanol (5 ml) was stirred over a period of 15 hrs at 90C as described in Method 1. Work-up and purification gave (3-(2-chloropyrimidin-4-ylamino)-2 -fluorophenyl) methanol (206 mg, 40.3 %) as a white solid. Mass Spectrum: M+H+ 254. NMR Spectrum (DMSOdbeta): 4.44 (s, 2H), 5.39 (bs, IH), 6.51 (bs, IH), 7.13 (ddd, IH), 7.30 (dd, IH), 7.36 (dd, IH), 8.09 (d, IH), 9.41 (bs, IH)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/104754; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts