Tag: M.W=100-200

Reference of 5-Methoxy-4-methylpyridin-3-amine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Methoxy-4-methylpyridin-3-amine, is researched, Molecular C7H10N2O, CAS is 77903-28-7, about Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections. Author is Magee, Thomas V.; Ripp, Sharon L.; Li, Bryan; Buzon, Richard A.; Chupak, Lou; Dougherty, Thomas J.; Finegan, Steven M.; Girard, Dennis; Hagen, Anne E.; Falcone, Michael J.; Farley, Kathleen A.; Granskog, Karl; Hardink, Joel R.; Huband, Michael D.; Kamicker, Barbara J.; Kaneko, Takushi; Knickerbocker, Michael J.; Liras, Jennifer L.; Marra, Andrea; Medina, Ivy; Nguyen, Thuy-Trinh; Noe, Mark C.; Obach, R. Scott; O’Donnell, John P.; Penzien, Joseph B.; Reilly, Usa Datta; Schafer, John R.; Shen, Yue; Stone, Gregory G.; Strelevitz, Timothy J.; Sun, Jianmin; Tait-Kamradt, Amelia; Vaz, Alfin D. N.; Whipple, David A.; Widlicka, Daniel W.; Wishka, Donn G.; Wolkowski, Joanna P.; Flanagan, Mark E..

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We have discovered a novel series of azetidinyl ketolides that focus on mitigation of hepatotoxicity by minimizing hepatic turnover and time-dependent inactivation of CYP3A isoforms in the liver without compromising the potency and efficacy of 1.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kuthan, J.; Musil, L.; Kohoutova, A. researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Category: alcohols-buliding-blocks.They published the article 《Dihydropyridines. XXIV. Partial hydrogenation of some 3,5-dicyanopyridines》 about this compound( cas:1195-58-0 ) in Collection of Czechoslovak Chemical Communications. Keywords: pyridine dihydro dicyano. We’ll tell you more about this compound (cas:1195-58-0).

Partial hydrogenation of 3,5-dicyanopyridine in EtOH over Pd on BaSO4 or BaCO3 gave a mixture of 3,5-dicyano-1,2-dihydropyridine and 3,5-dicyano-1,4-dihydropyridine. A similar hydrogenation of 3,5-dicyano-4-methylpyridine gave only the 1,2-dihydro derivative 3,5-Dicyano-2,6-dimethylpyridine and 3,5-dicyano-2,4,6-trimethylpyridine gave only traces of the 1,2- and 1,4-dihydro derivatives The mechanism of hydrogenation is discussed with the use of bicentric localization energies and simple Hueckel MO theory.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Dihydropyridines. XII. Electronic structure and reactivity of monocyanopyridines and symmetric dicyanopyridines》. Authors are Kuthan, J..The article about the compound:Pyridine-3,5-dicarbonitrilecas:1195-58-0,SMILESS:N#CC1=CC(C#N)=CN=C1).Related Products of 1195-58-0. Through the article, more information about this compound (cas:1195-58-0) is conveyed.

cf. CA 65, 3828a. The electronic structure of 2-cyanopyridine, 3-cyanopyridine, 4-cyanopyridine, 2,6-dicyanopyridine, and 3,5-dicyanopyridine were studied by means of the simple mol. orbital theory (HMO). The reactivity of these compounds toward nucleophilic reagents is discussed with respect to possible formation of corresponding dihydro derivatives or products with transformed functional groups. Ir, N.M.R., and uv spectra of the compounds studied are compared with the calculated values for the bond orders, π-electron densities, and with the theoretical excitation energies. Bond orders and π-electron densities as calculated on the basis of HMO-approximation are correlated with analogous data obtained by the self-consistent-field method.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Synthetic Route of C7H3N3.They published the article 《General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP》 about this compound( cas:1195-58-0 ) in Organic Letters. Keywords: aryl halide zinc cyanide nickel DMAP; cyanoarene preparation; heteroaryl halide zinc cyanide nickel DMAP; cyanoheteroarene preparation; nickel cyanation catalyst; DMAP cyanation mediator. We’ll tell you more about this compound (cas:1195-58-0).

A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl2·6H2O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides.

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Category: alcohols-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1H-Pyrazole-4-sulfonyl chloride, is researched, Molecular C3H3ClN2O2S, CAS is 438630-64-9, about Potent and Selective Nonpeptidic Inhibitors of Procollagen C-Proteinase.

6-Cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamides were previously disclosed as inhibitors of procollagen C-proteinase (PCP) culminating in the identification of amide 1. The objective was to discover a second inhibitor that would have improved affinity for PCP and to optimize properties for transepidermal delivery (TED) to intact skin. Further investigation of this template identified a number of potent PCP inhibitors (IC50 values of 2-6 nM) with improved TED flux. Sulfonamide (I) had excellent PCP enzyme activity when measured with a peptide substrate (Ki 8.7 nM) or with the endogenous substrate procollagen (IC50 3.4 nM) and demonstrates excellent selectivity over MMPs involved in wound healing (>10 000-fold). In the fibroplasia model, I inhibited deposition of insoluble collagen by 76±2% at 10 μM and was very effective at penetrating human skin in vitro with a TED flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo. Based on this profile, I (UK-421,045) was selected as a candidate for further preclin. evaluation as a topically applied, dermal antiscarring agent.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhao, Hui; Li, Yang; Zhu, Xiao-Qing researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).SDS of cas: 1195-58-0.They published the article 《Thermodynamic Parameters of Elementary Steps for 3,5-Disubstituted 1,4-Dihydropyridines To Release Hydride Anions in Acetonitrile》 about this compound( cas:1195-58-0 ) in ACS Omega. Keywords: dihydropyridine hydride ion source thermodn. We’ll tell you more about this compound (cas:1195-58-0).

A series of 3,5-disubstituted 1,4-dihydropyridine derivatives including the derivative with two chiral centers, 6H (R2 = CH3, CH2Ph), as a new type of organic hydride source were synthesized and characterized. The thermodn. driving forces (defined as enthalpy changes or standard redox potentials) of the 6 elementary steps for the organic hydrides to release hydride ions in acetonitrile were measured by isothermal titration calorimeter and electrochem. methods. The impacts of the substituents and functional groups bearing the N1 and C3/C5 positions on the thermodn. driving forces of the 6 elementary steps were examined and analyzed. Moreover, the results showed that the reaction mechanism between the chiral organic hydride and activated ketone (Et benzoylformate) was identified as the concerted hydride transfer pathway based on the thermodn. anal. platform. These valuable and crucial thermodn. parameters will provide a broadly beneficial impact on the applications of 3,5-disubstituted 1,4-dihydropyridine derivatives in organic synthesis and pharmaceutical chem.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Interception of amide ylides with sulfonamides: synthesis of (E)-N-sulfonyl amidines catalyzed by Zn(OTf)2, published in 2017, which mentions a compound: 7661-33-8, mainly applied to sulfonyl amidine preparation diastereoselective crystal structure mol; sulfonamide amide intermol condensation zinc catalyst, Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.

An efficient method was reported for the synthesis of (E)-N-sulfonyl amidines such as I [R1 = H, Me, Ph, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Me, i-Pr, Ph, etc.; R1R3 = (CH2)2, (CH2)3; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2, etc.; R4 = Ph, 4-MeC6H4, 2-naphthyl, etc.] in good yields with excellent stereoselectivity via Zn-catalyzed intermol. condensation reaction between sulfonamides and various amides. The wide substrate scope, exceptional functional group tolerance, operational simplicity and neutral reaction conditions made this mechanistically novel method well suited for preparing amidine compounds I.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling, published in 2016-05-15, which mentions a compound: 438630-64-9, Name is 1H-Pyrazole-4-sulfonyl chloride, Molecular C3H3ClN2O2S, COA of Formula: C3H3ClN2O2S.

One of the challenges for targeting B-RafV600E with small mol. inhibitors had been achieving adequate selectivity over the wild-type protein B-RafWT, as inhibition of the latter has been associated with hyperplasia in normal tissues. Recent studies suggest that B-Raf inhibitors inducing the ‘DFG-in/αC-helix-out’ conformation (Type IIB) likely will exhibit improved selectivity for B-RafV600E. To explore this hypothesis, we transformed Type IIA inhibitor (1) into a series of Type IIB inhibitors (sulfonamides and sulfamides 4-6) and examined the SAR. Three selectivity indexes were introduced to facilitate the analyses: the B-RafV600E/B-RafWT biochem. (bS), cellular (cS) selectivity, and the phospho-ERK activation (pA). Our data indicates that α-branched sulfonamides and sulfamides show higher selectivities than the linear derivatives We rationalized this finding based on anal. of structural information from the literature and provided evidence for a monomeric B-Raf-inhibitor complex previously hypothesized to be responsible for the desired B-RafV600E selectivity.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dihydropyridines. XV. Reactions of some 3,5-dicyanopyridines with complex aluminum hydrides, published in 1968, which mentions a compound: 1195-58-0, Name is Pyridine-3,5-dicarbonitrile, Molecular C7H3N3, Computed Properties of C7H3N3.

The effect of 4 complex Al hydrides on the formation of the 1,2- and 1,4-dihydro derivatives was studied. The reductions were carried out in tetrahydrofuran or Et2O and the products separated by thin layer chromatography (the starting compound I, reagent, % yield of the mixture, product(s), and their ratio given): I (R1 = R2 = H), LiAlH4, NaAlH4, NaAlH2(OEt)2, 41-98, II (R1 = R2 = H), III (R1 = R2 = H), 44-7: 53-6; I (R1 = R2 = H), NaAlH2(OCH2CH2OMe)2, 12, II (R1 = R2 = H), 100%; I (R1 = H, R2 = Me), LiAlH4, 36, III (R1 = H, R2 = Me), 100%; I (R1 = H, R2 = Et), LiAlH4, 25, II (R1 = H, R2 = Et), III (R1 = H, R2 = Et), 91:9; I (R1 = Me, R2 = H), LiAlH4, 80, II (R1 = Me, R2 = H), 100%; I (R1 = R2 = Me), LiAlH4, 65, II (R1 = R2 = Me), III (R1 = R2 = Me), 43:57; and I (R1 = Me, R2 = Et), LiAlH4, 48, II (R1 = Me, R2 = Et), III (R1 = Me, R2 = Et), 20:80.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology, published in 2019-11-25, which mentions a compound: 7661-33-8, mainly applied to amidation aryl chloride tandem transhalogenation arylation copper catalyst microwave, Formula: C10H10ClNO.

A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

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