In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology, published in 2019-11-25, which mentions a compound: 7661-33-8, mainly applied to amidation aryl chloride tandem transhalogenation arylation copper catalyst microwave, Formula: C10H10ClNO.
A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.
Although many compounds look similar to this compound(7661-33-8)Formula: C10H10ClNO, numerous studies have shown that this compound(SMILES:O=C1N(C2=CC=C(Cl)C=C2)CCC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts