Category: 13588-28-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol, molecular formula is C7H16O3, molecular weight is 148.2001, as common compound, the synthetic route is as follows.Recommanded Product: 2-(2-Methoxypropoxy)propan-1-ol

In a thermometer,Distillation column, condenser,Water separator 1000ml glass four-necked flask,Add dipropylene glycol methyl ether 296g, acetic acid 132g,The molar ratio of dipropylene glycol methyl ether and acetic acid is 1: 1.1,Acid ionic liquid catalyst 1-butyl-3-methyl imidazole bisulfate dosage of 17.1g,The dehydrating agent cyclohexane was 148 g,The temperature was raised and the reaction was kept in boiling (80-160 C)Back to divert water,4h reaction was completed, the reaction was weighed,Gas chromatography analysis of the reaction solution of dipropylene glycol methyl ether acetate content, the calculated yield of 98.4%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Tianyin Chemical Co., Ltd.; Qin Yisheng; Qin Xiaoqi; Yang Jianguo; Zhang Xuejun; Chen Rongfu; (7 pag.)CN106966898; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 13588-28-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Jimroth type reflux condenser, Dean-Stark trap tube,In a 100 mL two-necked flask equipped with a nitrogen inlet tube,Dipropylene glycol monomethyl ether represented by the following formula (20) (with isomer) (7.41 g, 50 mmol), vinylacetic acid synthesized in Example 1 (formula (1-0),4.74 g, 55 mmol),p-Toluenesulfonic acid monohydrate (0.48 g, 2.5 mmol)And toluene (35 mL) was added.Immerse the two-necked flask in an oil bath,The temperature of the oil bath was raised to 130 C.While maintaining the same temperature, the mixture was stirred for 4 hours under a nitrogen stream to distill off the by-produced water.Cool the two-necked flask to room temperature (25 C),Wash twice with 5 wt% aqueous sodium bicarbonate (10 mL),Further, after washing twice with distilled water (10 mL), it was dried over magnesium sulfate. After removing the magnesium sulfate, the solution was concentrated under reduced pressure in the same manner as in Example 2. The obtained concentrated residue was purified by distillation under reduced pressure to isolate the compound (1-1b) (10.57 g, yield 98%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol.

Reference:
Patent; JNC Corporation; Masayuki, Sato; Urata, Yasuo; Yatsuda, Shinichi; Masuhara, Shigeo; Hashimoto, Kazuki; (20 pag.)JP5803424; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 13588-28-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol. A new synthetic method of this compound is introduced below.

In a 500 mL flask, feed NaOH tablets 55. 2 g (relative to the following DPMI moles,Equivalent to 1. 5 moles)And 1-bromo-3-methylbutane(Manufactured by Yancheng Longsheng Chemical Co., Ltd.) (hereinafter also referred to as “IABr”) 163.5 g (relative to the following DPMI moles,Equivalent to 1. 2 moles)Start stirring.After raising the liquid temperature to 45 C,While keeping the temperature inside the system at 45 C,DPM133. 7 g was added dropwise over 6 hours.Thereafter,Stirring was carried out while maintaining a 45 C condition.In addition,The low boiling compounds produced in the above reaction were measured using a gas flow meter and gas chromatography3-methyl-1-butene.To the reaction solution was added water 155. 7 g was subjected to extraction / separation,The results of the analysis of the obtained organic phase 222. 5 g using gas chromatography,Got 125. 0gOf dipropylene glycol methyl isopentyl ether(Isomer mixture) (hereinafter also referred to as “”DPMIA”).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Daicel Corporation; Mori, Atsushi; (9 pag.)CN105503545; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 13588-28-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13588-28-8 as follows.

EXAMPLE 1 16 Parts of 1,4-dihydroxynaphthalene was added to 100 parts of dipropylene glycol monomethyl ether in a reaction vessel provided with a stirrer under a nitrogen atmosphere at room temperature. 42.5 Parts of 28% sodium methylate was added dropwise thereto. Then the reaction mixture was heated to 180 C. and maintained at this temperature for 1 hour. During this period, 36 parts of a distillate mainly composed of methanol was removed out of the reaction system. After cooling to 110 C., carbon dioxide gas was blown into the reaction mixture under atmospheric pressure. Although the absorption of the carbon dioxide gas was completed within 15 minutes, carbon dioxide gas was further blown for additional 15 minutes. 1,4-Dihydroxy-2-naphthoic acid produced in the reaction mixture was isolated in the following manner:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13588-28-8, its application will become more common.

Reference:
Patent; Sumitomo Chemical Company, Limited; Sumika Fine Chemicals Co., Ltd.; US5599971; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 13588-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol, molecular formula is C7H16O3, molecular weight is 148.2001, as common compound, the synthetic route is as follows.

In a 500 mL flask, flake-like sodium hydroxide (manufactured by Tosoh Corporation) (hereinafter also referred to as”NaOH tablets”) 51.5 g (relative to the following DPMI moles,Equivalent to 1. 4 moles)And 1-bromopropane (manufactured by Wako Pure Chemical Industries, Ltd.) (hereinafter also referred to as “PrBr”) 144.2 g(Relative to the following DPMI moles,Equivalent to 1. 3 moles)Start stirring.After raising the liquid temperature to 35 C,While keeping the temperature inside the system at 35 C,(Hereinafter referred to as “DPM”) was added dropwise over 6 hours to a solution of 133.7 g of dipropylene glycol monomethyl ether (isomer mixture) (manufactured by Wako Pure Chemical Industries, Ltd.).Thereafter,The overnight stirring was carried out while maintaining the temperature of 35 C.In addition,The amount of propylene gas as a low boiling compound produced in the above reaction was measured using a gas flow meter.The reaction solution was added with water 118. After 5 g, extraction /The resulting organic phase 194. 6 g was analyzed by gas chromatography,As a result, it was found that dipropylene glycol methyl n-propyl ether (isomer mixture) (hereinafter also referred to as “DPMNP”) 136.3 g (DPM basis yield: 79.4%, PrBr basis yield: 61 . 1% ).

Statistics shows that 13588-28-8 is playing an increasingly important role. we look forward to future research findings about 2-(2-Methoxypropoxy)propan-1-ol.

Reference:
Patent; Daicel Corporation; Mori, Atsushi; (9 pag.)CN105503545; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts