With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol, molecular formula is C7H16O3, molecular weight is 148.2001, as common compound, the synthetic route is as follows.Recommanded Product: 2-(2-Methoxypropoxy)propan-1-ol
In a thermometer,Distillation column, condenser,Water separator 1000ml glass four-necked flask,Add dipropylene glycol methyl ether 296g, acetic acid 132g,The molar ratio of dipropylene glycol methyl ether and acetic acid is 1: 1.1,Acid ionic liquid catalyst 1-butyl-3-methyl imidazole bisulfate dosage of 17.1g,The dehydrating agent cyclohexane was 148 g,The temperature was raised and the reaction was kept in boiling (80-160 C)Back to divert water,4h reaction was completed, the reaction was weighed,Gas chromatography analysis of the reaction solution of dipropylene glycol methyl ether acetate content, the calculated yield of 98.4%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Tianyin Chemical Co., Ltd.; Qin Yisheng; Qin Xiaoqi; Yang Jianguo; Zhang Xuejun; Chen Rongfu; (7 pag.)CN106966898; (2017); A;,
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