In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53072-18-7, name is (2,3,4,5-Tetrafluorophenyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 53072-18-7
To a solution of 1,1′-carbonyldiimidazole (1.72 g, 10.6 mmol) in MeCN (50 mL) was added 1,2,3,4-tetrafluorobenzyl alcohol (1.74 g, 9.68 mmol). The resulting mixture was stirred at room temperature for 3 h. Hydroxylamine hydrochloride (2.70 g, 39.7 mmol) was then added followed by imidazole (1.98 g, 29.0 mmol) and the resulting mixture was stirred for 16 h. The suspension was concentrated under reduced pressure. The white residue was dissolved in a 1:1 mixture of ethyl acetate and HClaq 10% (50 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with brine (50 mL) and dried over MgSO4. The solvent was removed under reduced pressure and the resulting N-hydroxycarbamate used without further purification. To a solution of N-hydroxycarbamate (2.28 g, 9.55 mmol) in ether (90 mL) at 0 C was added tosyl chloride (1.91 g, 10.0 mmol). Triethylamine (1.39 mL, 10.0 mmol) was then slowly added to the solution. The resulting white suspension was stirred at room temperature for 2 h. Water (25 mL) was added to the solution and the two layers were separated. The aqueous layer was washed with ether (2×20 mL). The combined organic layers were washed with brine (20 mL), dried over MgSO4, and the solvent was removed under reduced. The desired N-tosyloxycarbamate 1b (2.78 g, 72% yield) was obtained as a white solid after flash chromatography (20% EtOAc/hexanes).
The synthetic route of 53072-18-7 has been constantly updated, and we look forward to future research findings.
Reference:
Conference Paper; Lebel, Helne; Parmentier, Michael; Leogane, Olivier; Ross, Karen; Spitz, Cedric; Tetrahedron; vol. 68; 17; (2012); p. 3396 – 3409;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts