Category: 10029-04-6

Electric Literature of 10029-04-6, Adding some certain compound to certain chemical reactions, such as: 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate,molecular formula is C6H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10029-04-6.

Phosphorus tribromide (17.16 g, 63.41 MMOL) was added to a stirred solution of the compound of example 30 (17.92 g, 138.1 MMOL) in dry ether (132 mL) at-10 C. The temperature was allowed to rise to 20 C and stirring was continued for 3h. Water (80 mL) was then added at-10 C and the mixture was extracted with hexane (3 x 45 mL). The organic extracts were washed with saturated sodium chloride solution (2 x 45 mL) and dried with anhydrous MGS04. Evaporation of solvent under vacuum gave 15.07 g (yield 56.6 %) of the crude product, which was used directly in the next reaction without any further purification. 1H NMR (CDCI3, 400MHZ) 8 6.25 (s, 1H), 5.88 (s, 1H), 4.2 (q, 2H), 4.11 (s, 2H), 1.25 (t, 3H); 13C NMR (CDCI3, 400 MHz) 5 166. 7,140. 1,125. 3,61. 1, 53.9, 14.4

According to the analysis of related databases, 10029-04-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOMEP INC.; WO2004/50620; (2004); A2;,
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Reference of 10029-04-6 ,Some common heterocyclic compound, 10029-04-6, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1.0 g (7.7 mmol) hydroxymethyl acrylate was dissolved in 1.5 mol 5 weight-% sodium hydroxide solution (0.46 g; 11.6 mmol NaOH) and stirred for 4 hours at room temperature. After several extractions with diethyl ether, the ether phase was washed with water, dried over calcium chloride and the product was dried in vacuum. Yield: 0.47 g (60%) 1H-NMR [ppm]: delta (500 MHz, CDCl3)=3.2 (HO-CH2); 4.2 (HO-CH2); 5.85 (=CH2); 6.25 (=CH2); 12.5 (O=C-OH)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DENTSPLY International Inc.; KLEE, JOACHIM E; RITTER, HELMUT; POHLE, SVEN; ELSNER, OLIVER; BARDTS, MAREIKE; US2015/238390; (2015); A1;,
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Electric Literature of 10029-04-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10029-04-6 as follows.

Using compound (T-4) (50.0 g) as a starting material, imidazole (28.7 g) and methylene chloride (800 ml) were placed in a reactor and cooled to 0 C.A solution of t-butyldiphenylchlorosilane (116.1 g) in methylene chloride (110 ml) was slowly added dropwise thereto, returned to room temperature and stirred for 12 hours.The reaction mixture was poured into water and the aqueous layer was extracted with dichloromethane.The organic layer formed simultaneously with water washing was dried over anhydrous magnesium sulfate.The solution was concentrated under reduced pressure and the residue was purified by silica gel chromatography (volume ratio, heptane: ethyl acetate = 10: 1) to obtain Compound (T-17) (127.4 g; 90%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10029-04-6, its application will become more common.

Reference:
Patent; Jieenzhi Co., Ltd.; Jieenzhi Petrochemical Co., Ltd.; Tian Zhongyuzhi; Shi Yekuangyi; Jin Tengshishang; Di Tianhekuan; (145 pag.)CN107108457; (2017); A;,
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Reference of 10029-04-6 , The common heterocyclic compound, 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 2-hydroxymethyl-acrylic acid ethyl ester (260 mg, 2 mmol) and imidazole (163 mg, 2.4 mmol) in dry DMF (5 ml) was added tert- butyldimethylsily. chloride (362 mg, 2.4 mmol). The reaction mixture was stirred overnight and diluted with ether, washed with water three times and dried over MgSO4. Solvent was removed under reduced pressure to provide a crude product that was purified by column chromatography using a solution of ethyl acetate in hexanes (1 :6) to obtain the title product (463 mg, 95%).

The synthetic route of 10029-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2007/97937; (2007); A1;,
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Application of 10029-04-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. This compound has unique chemical properties. The synthetic route is as follows.

Example 5. To a stirring mixture of monoethyl malonate (5.1 g, 38.6 mmol) , ethyl 2-hydroxylmethyl acrylate (5.02 g, 3.86 mmol), PTSA (50 mg) and hydroquinone (50 mg) , was added toluene (50 mL) and the mixture was refluxed at a temperature of 15O0C to azeotropically remove water.[0079] After cooling, the reaction product was washed consecutively with 30% brine and water, and the organic layer was dried over anhydrous sodium sulfate, filtered and the solvent removed by rotary evaporator. The crude reaction product was purified by vacuum distillation (98- 100C/0.1 mbar) and the ester, C was isolated in 80% yield. 1H NMR (60 MHz, CDCl3) : delta 6.36 (s, IH), 5.87 (s, 1 H), 4.89(s, 2 H), 4.05-4.41 (m, 4 H), 3.43 (s, 2 H), 1.19-1.42 (m, 6 H); FT-IR (film) : 2984.7, 2908.6, 1735.3 (br) , 1640.5, 1513,6, 1447.6, 1332.2, 1145.4, 1031.7, 817.2 cm-1; GC/MS(EI) m/z (%) : 245 (2) [M++ H], 226 (2), 199 (20), 153 (20), 129 (70), 115 (100), 101 (40), 85 (45), 43 (65) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Patent; LOCTITE (R & D) LIMITED; WO2009/53484; (2009); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, the common compound, a new synthetic route is introduced below. Application In Synthesis of Ethyl 2-(hydroxymethyl)acrylate

To a stirred solution of 2-hydroxymethyl-acrylic acid ethyl ester (260 mg, 2 mmol) and imidazole (163 mg, 2.4 mmol) in dry DMF (5 ml) was added tert- butyldimethylsilyl chloride (362 mg, 2.4 mmol). The reaction mixture was stirred overnight and diluted with ether, washed with water three times and dried over MgSO4. Solvent was removed under reduced pressure to provide a crude product that was purified by column chromatography using a solution of ethyl acetate in hexanes (1:6) to obtain the title product (463 mg, 95%).

The synthetic route of 10029-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Ethyl 2-(hydroxymethyl)acrylate

General procedure: Under N2 atmosphere and at 0 C, to a stirred solution of MBHalcohols 1 (0.3 mmol) and PPh3 (0.6 mmol) in EtOAc orCH2Cl2 (2 mL) in a Schlenk tube (25 mL) was slowly addedazodicarboxylates 2 (0.6 mmol) over 5 minutes by the means ofa microsyringe. The resulting reaction mixture was allowed towarm up to room temperature and stirred until the MBH alcohols1 were completely consumed, as monitored by TLC. Thesolvent was removed under reduced pressure and the residuewas purified by column chromatography on silica gel (gradienteluant: petroleum ether/ethyl acetate 9:1-3:1) to afford thehydrazines 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Xu, Silong; Shang, Jian; Zhang, Junjie; Tang, Yuhai; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 990 – 995;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., name: Ethyl 2-(hydroxymethyl)acrylate

General procedure: To a solution of the appropriate allylic alcohol 6 (1.00 equiv.) in dichloromethane (0.1 M) was added vinyl acetic acid 7 (1.20 equiv.), dicyclohexylcarbodiimide (1.20 equiv.) and 4-N,N-dimethylaminopyridine (0.15 equiv.) at 0C. The mixture was allowed to warm to ambient temperature and stirred until the product was fully converted (TLC). The solution was filtered and the filter cake was washed three times with dichloromethane. The combined organic layers were washed with aq. HCl (1 M) and then with saturated aq. NaHCO3 solution, dried with Na2SO4, filtered and dry-loaded on silica gel. The pure product was obtained after column chromatography on silica, using hexane/MTBE mixtures of increasing polarity as eluents.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Schmidt, Bernd; Audoersch, Stephan; Kunz, Oliver; Synthesis; vol. 48; 24; (2016); p. 4509 – 4518;,
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Application of 10029-04-6 ,Some common heterocyclic compound, 10029-04-6, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Ethyl 2-(hydroxymethyl)acrylate 3 (1470 mg, 11.31 mmol), triphenylphosphine (3259 mg, 12.44 mmol) and BocNHTos (3360 mg, 12.44 mmol) were dissolved in dry THF (110 mL). Diisopropyl azodicarboxylate (2512 mg, 12.44 mmol) was slowly added at 0 C and the reaction mixture was stirred at room temperature for 24 h. Evaporation of the solvent and purification by flash chromatography on silica gel (petroleum ether/EtOAc 9:1) afforded pure compound 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10029-04-6, its application will become more common.

Reference:
Article; ?ukauskaite, Asta; Mangelinckx, Sven; Callebaut, Gert; Wybon, Clarence; ?a?kus, Algirdas; De Kimpe, Norbert; Tetrahedron; vol. 69; 16; (2013); p. 3437 – 3443;,
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Electric Literature of 10029-04-6, Adding some certain compound to certain chemical reactions, such as: 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate,molecular formula is C6H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10029-04-6.

Example 1(0189)With reference to FIG. 1, the first generic compound in the synthetic sequence (structure I) is prepared where X is CN, W is H, X? is CO2Et, and L is H.(0190)More specifically, in a 1 liter three-necked flask, alpha(hydroxymethyl)ethylacrylate (260.0 g, 2.0 mol) and 1.1 equivalent of cyanoacetic acid (187.0 g, 2.2 mol) were suspended in toluene (420 mL) with hydroquinone (0.8 g). The mixture was heated at a temperature of 90 C. until the cyanoacetic acid melted, at which point a catalytic amount (two drops) of sulfuric acid was added. The reaction mixture was stirred with heating at a temperature of 125 C. with a Dean-Stark apparatus attached to remove the water.(0191)The reaction mixture was washed with dilute aqueous sodium bicarbonate to remove excess cyanoacetic acid, then with dilute hydrochloric acid and finally with brine. The solvent (toluene) was removed under reduced pressure and the residue with an added 1 g of hydroquinone was distilled (b.p. 130 C. at 0.2 mm Hg) to furnish 197 g of the final product in a yield of 51%. Spectral confirmation is given below.(0192)1H-NMR (60 MHz, CDCl3): delta=1.32 (t, 3H), 3.49 (s, 2H), 4.24 (q, 2H), 4.92 (s, 2H), 5.90 (s, 1H), 6.41 (s, 1H) ppm.(0193)FT-IR (film): 2983.1, 2929.4, 2259.3, 1750.8, 1712.7, 1638.8, 1447.4, 1395.9, 1367.9, 1336.0, 1309.1, 1270.0, 1176.4, 1152.9, 1023.5, 957.7, 879.3, 859.1, 815.9 cm-1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Henkel Ireland Limited; Gherardi, Stefano; McArdle, Ciaran B.; Faimani, Giovanni; Loschen, Christoph; US8399698; (2013); B1;,
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