Category: 153759-59-2

The author of 《Design, synthesis and in vitro evaluation of coumarin-imidazo[1,2-a]pyridine derivatives against cancer induced osteoporosisã€?were Sashidhara, Koneni V.; Singh, L. Ravithej; Choudhary, Dharmendra; Arun, Ashutosh; Gupta, Sampa; Adhikary, Sulekha; Palnati, Gopala Reddy; Konwar, Rituraj; Trivedi, Ritu. And the article was published in RSC Advances in . Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

A series of biol. important 6-(imidazo[1,2-a]pyridin-2-yl)-2H-chromen-2-one derivatives were synthesized by employing the silver(I) catalyzed Groebke-Blackburn-Bienayme multicomponent reaction. The synthesized compounds were tested in a primary calvarial osteoblast cells by alk. phosphatase assay and an alizarin red-S staining assay for their possible osteoprotective properties. Further, the effects of active compounds 6h, 6l, and 6o on the expression of osteogenic genes BMP2, RUNX2, COL1, and OCN were measured by qPCR. Out of three promising compounds, 6l and 6o significantly induced apoptosis in MDA-MB-231 cancer cells via mitochondrial depolarisation without affecting normal cells. In an in vitro co-culture model of bone metastasis, we investigated the ability of coumarin-imidazo[1,2-a]pyridine hybrids to reverse the neg. impact of MDA-MB-231 cancer cells on osteoblast differentiation. The results illustrate the potential of designed hybrids to re-establish the bone homeostasis. These findings demonstrate the significance of newly synthesized hybrids as lead mols., possessing both antiosteoporotic and anticancer properties that can be developed into new therapeutic agents to alleviate osteoporosis and bone metastasis. In the experimental materials used by the author, we found 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

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Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehydeOn September 2, 2013 ,《One-pot regioselective synthesis of imidazole and 2,3-dihydroquinazolinone derivatives – an easy access to “”nature-like molecules””; part XIII in the series: “”studies on novel synthetic methodologies””》 was published in Synlett. The article was written by Sashidhara, Koneni V.; Palnati, Gopala Reddy; Dodda, Ranga Prasad; Avula, Srinivasa Rao; Swami, Priyanka. The article contains the following contents:

A mild and highly practical regioselective synthesis of imidazole and 2,3-dihydroquinazolinone derivatives from 5-alkyl-4-hydroxyisophthalaldehydes with suitable substrates in acetic acid is reported. Further exploration of the mol. diversity of 2,3-dihydroquinazolinone is demonstrated by the synthesis of diverse pharmacol. relevant natural-product-like scaffolds. In the experiment, the researchers used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehydeDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2020,Dalton Transactions included an article by Sun, Xiaoman; Meng, Fanyu; Su, Qing; Luo, Kexin; Ju, Pengyao; Liu, Ziqian; Li, Xiaodong; Li, Guanghua; Wu, Qiaolin. Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde. The article was titled 《New catalytically active conjugated microporous polymer bearing ordered salen-Cu and porphyrin moieties for Henry reaction in aqueous solution》. The information in the text is summarized as follows:

A catalytically active conjugated microporous polymer (SP-CMP-Cu) was facilely constructed with condensation polymerization of salen-Cu [salen = N,N’-bis(3-tertbutyl-5-formylsalicylidene) ethylenediamine] and pyrrole. The as-synthesized SP-CMP-Cu was completely characterized by powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR) spectroscopy, thermogravimetric anal. (TGA), XPS, and energy-dispersive X-ray (EDX) anal. The morphol. features of SP-CMP-Cu were revealed by SEM and transmission electron microscopy (TEM). According to N2 adsorption/desorption isotherm, Brunauer-Emmett-Teller (BET) surface area of SP-CMP-Cu was calculated to be 252 m2 g-1 with a total pore volume of 0.178 cm3 g-1. SP-CMP-Cu exhibited an outstanding catalytic performance for Henry reaction in aqueous solutions with excellent conversion and good selectivity. Moreover, SP-CMP-Cu can be reused for up to five consecutive runs without any significant loss in its catalytic efficiency.5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde) was used in this study.

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

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Alcohol – Wikipedia,
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In 2016,MedChemComm included an article by Sashidhara, Koneni V.; Rao, K. Bhaskara; Sonkar, Ravi; Modukuri, Ram K.; Chhonker, Yashpal S.; Kushwaha, Pragati; Chandasana, Hardik; Khanna, A. K.; Bhatta, Rabi S.; Bhatia, Gitika; Suthar, Manish Kumar; Saxena, Jitendra Kumar; Kumar, Vikash; Siddiqi, Mohammad Imran. Recommanded Product: 153759-59-2. The article was titled 《Hybrids of coumarin-indole: design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models》. The information in the text is summarized as follows:

In this study, a series of coumarin-indole hybrids have been synthesized and evaluated for their lipid lowering activity. Preliminary biol. screening of the synthesized compounds was undertaken in an in vitro model of the HMG-CoA reductase enzyme, and the activity was confirmed in Triton WR-1339 induced hyperlipidemic rats. Among the hybrids, compound 26 was found to be the best as it significantly reduced the serum and hepatic lipid profiles in an HFD-fed hyperlipidemic rat model. The mechanism of action seems to be associated with the regulation of HMG-CoA reductase activity in the liver, which is in good agreement with binding mode studies. Compound 26 exhibited favorable pharmacokinetic behavior for its oral administration, which underscores the potential of this template as a new class of hypolipidemic agents. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Recommanded Product: 153759-59-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Design, synthesis and anticancer activity of dihydropyrimidinone-semicarbazone hybrids as potential human DNA ligase 1 inhibitors》 were Sashidhara, Koneni V.; Singh, L. Ravithej; Shameem, Mohammad; Shakya, Sarika; Kumar, Anoop; Laxman, Tulsankar Sachin; Krishna, Shagun; Siddiqi, Mohammad Imran; Bhatta, Rabi S.; Banerjee, Dibyendu. And the article was published in MedChemComm in 2016. Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

A series of new dihydropyrimidinone-semicarbazone hybrids were successfully synthesized by integrating regioselective multicomponent reaction with the pharmacophore hybridization approach. All the synthesized compounds were evaluated for their hLig1 inhibition potency and most of them were found to be good to moderately active. Out of the tested derivatives, compound 6f showed selective anti-proliferative activity against HepG2 cells in a dose-dependent manner with an IC50 value of 10.07 ± 1.2. It also reduced cell survival at ≤20 μM concentration Further, anal. of treated HepG2 cell lysates by western blot assay showed increased γ-H2AX levels and upregulation of p53, leading to apoptosis. In silico docking results explain the binding modes of compound 6f to the DNA-binding domain of hLig1 enzyme thereby preventing its nick sealing activity. In addition, the favorable pharmacokinetic properties suggest that this new class of hLig1 inhibitors could be promising leads for further drug development. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Kumar, Abdhesh; Dodda, Ranga Prasad; Kumar, Bikash published an article in Tetrahedron Letters. The title of the article was 《A new iodine catalyzed regioselective synthesis of xanthene synthons》.COA of Formula: C12H14O3 The author mentioned the following in the article:

This Letter describes the iodine catalyzed one-pot regioselective synthesis of p-condensed xanthenes as our key point of transformation, which provides an efficient access to five skeletally diverse scaffolds in excellent yields. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

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Alcohol – Wikipedia,
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The author of 《Synthesis of 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes》 were Sashidhara, Koneni V.; Kumar, Abdhesh; Rao, K. Bhaskara. And the article was published in Tetrahedron Letters in 2011. HPLC of Formula: 153759-59-2 The author mentioned the following in the article:

Convenient and facile one step synthesis of medicinally relevant 3,6-epoxy[1,5]dioxocines e. g., I from 2-hydroxyarom. benzaldehydes is described. The scope of the method was validated by examining the use of both electron rich and electron-deficient 2-hydroxyarom. benzaldehydes. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2HPLC of Formula: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).HPLC of Formula: 153759-59-2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A Practical Method for the Large-Scale Preparation of [N,N’-Bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]manganese(III) chloride, a Highly Enantioselective Epoxidation Catalyst》 was written by Larrow, Jay F.; Jacobsen, Eric N.; Gao, Yun; Hong, Yaping; Nie, Xiaoyi; Zepp, Charles M.. SDS of cas: 153759-59-2 And the article was included in Journal of Organic Chemistry on April 8 ,1994. The article conveys some information:

An improved method is reported for the preparation of both enantiomers of N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese (III) chloride, highly enantioselective catalysts for the epoxidation of a wide variety of olefins. The key improvements in the process were the application of the Duff reaction to the synthesis of 3,5-di-tert-butyl-2-hydroxylbenzaldehyde from the corresponding phenol, and a simplified procedure for the resolution of a racemic trans/cis mixture of 1,2-diaminocyclohexane. The Duff reaction is generally applicable to 2,4-disubstituted phenols, and the corresponding salicylaldehydes can be integrated into the described procedure to produce sterically and electronically modified asym. epoxidation catalysts. The synthesis eliminates the need for special handling of hazardous reagents and allows for the production on the multi-hundred kg scale. The experimental part of the paper was very detailed, including the reaction process of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2SDS of cas: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.SDS of cas: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modukuri, Ram K.; Choudhary, Dharmendra; Gupta, Sampa; Rao, K. Bhaskara; Adhikary, Sulekha; Sharma, Tanuj; Siddiqi, Mohammad Imran; Trivedi, Ritu; Sashidhara, Koneni V. published their research in Bioorganic & Medicinal Chemistry on December 15 ,2017. The article was titled 《Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents》.Recommanded Product: 153759-59-2 The article contains the following contents:

A series of novel benzofuran-dihydropyridine hybrids were designed by mol. hybridization approach and evaluated for bone anabolic activities. Among the screened library, compound I significantly enhanced the ALP production and mineralized nodule formation, which are primary requisites in the process of in vitro osteogenesis. Oral administration of compound I at 10 mg·kg-1·day-1 for two weeks led to restoration of trabecular bone microarchitecture in drill hole fracture model by significantly increasing BV/TV and Tb. N. Furthermore, histol. and mol. studies showed compound I triggering the new bone regeneration in a drill hole defect site by increasing BMP expression. Furthermore, mol. modeling studies were performed to gain insight into the binding approach, which revealed that both benzofuran and dihydropyridine moieties are essential to show similar binding interactions to fit into the active site of BMP2 receptor, an important target of the osteogenic agents. The results suggest that compound I stimulates BMP2 synthesis in osteoblast cells that promotes new bone formation (∼40%) at the fracture site which helps in shorten the healing period. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gupta, Sampa; Maurya, Pooja; Upadhyay, Akanksha; Kushwaha, Pragati; Krishna, Shagun; Siddiqi, Mohammad Imran; Sashidhara, Koneni V.; Banerjee, Dibyendu published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents》.Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing the nick joining between DNA strands. As compared to normal cells, elevated levels of human DNA ligase I (hLigI) is reported in some cancers. The authors studied the inhibition of hLigI mediated DNA nick sealing activity followed by the antiproliferative activity of novel indole-chalcone based benzopyran compounds on cancer cells. One mol. called compound 27 ((E)-2-amino-8-(tert-butyl)-4-(2-methyl-1H-indol-3-yl)-6-(3-oxo-3-(thien-2-yl)prop-1-en-1-yl)-4H-chromene-3-carbonitrile) showed a notable preference for inhibition of hLigI as compared to other ligases and showed enhanced cytotoxicity against colon cancer (DLD-1) cells as compared to normal cells. Mechanistic studies showed that compound 27 directly interacts with hLigI in a competitive manner and did not interact with the DNA substrate during ligation. This novel and potent hLigI inhibitor showed significant inhibition of both monolayer culture as well as 3D culture of DLD-1 cells that mimic solid tumor. It also affected the migration of DLD-1 cells indicating the potential anti-metastatic activity. This novel hLigI inhibitor could therefore serve as a promising lead for anticancer drug development. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehydeDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts