Category: 115-20-8

Synthetic Route of 115-20-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below.

To a suspension of (2-benzyloxy-3,5-dimethyl) phenoxyacetic acid (270 mg, 0.94 mmol) and 1,3-dicyclohexylcarbodimide (292.0 mg, 1.41 mmol) in CH2Cl2 (10.0 mL) was added pyridine (76.0 mL) and 2,2,2-trichloroethanol (117.0 mL). The suspension was stirred at room temperature for 12 h. The precipitation was filtered through filter paper and the filtrate was concentrated. Flash column (EtOAc in hexanes 5% to 10%) afforded 12c (311.1 mg) in 78.9% yield as an oil. [00783] 1H NMR (CDCl3) ¶7.52-7.28 (m, 5H, C6H5), 6.67 (s, 1H, C6H2), 6.60 (s, 1H, C6H2), 5.04 (s, 2H, CH2C6H5), 4.85 (s, 2H, OCH2CO), 4.84 (s, 2H, OCH2CCl3), 2.26 (s, 3H, CH3C6H2), 2.19 (s, 3H, CH3C6H2); 13C NMR d 167.6, 150.3, 144.4, 137.8, 133.4, 132.5, 128.3, 128.3, 127.8, 125.1, 125.1, 113.1, 94.4. 74.6, 74.0, 65.8, 21.1, 16.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,115-20-8, Trichloroethanol, and friends who are interested can also refer to it.

Reference:
Patent; University of Arkansas; US6657052; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 115-20-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.

A solution of 3-tert-butyl-5-methylsulfamoyl-benzoic acid (WO 2008/021388, which is incorporated herein by reference in its entirety, 400 mg, 1.47 mmol) in THF (10 ml) was treated with TEA (270 mu1, 1.91 mmol) and DPPA (412 mul, 1.91 mmol). The reaction mixture was stirred at RT for 1 hour and then 2,2,2-trichloro-ethanol (225 mul, 2.35 mmol) was added. The reaction mixture was heated at 70 C. for 18 hours and cooled at RT. The volatiles were removed under reduced pressure and the residue was partitioned between EtOAc and an aqueous 5% citric acid solution. The two phases were separated and the aqueous phase was extracted with EtOAc. The combined organic phases were washed with a saturated aqueous NaHCO3 solution and brine, dried with Na2SO4 and the solvent was removed under reduced pressure. Purification by FCC, eluting with 0-70% EtOAc/cyclohexane gave the title compound (429 mg, 70%). 1H NMR (300 MHz, CDCl3): 1.35 (9H, s), 2.69 (3H, d, J=5.4 Hz), 4.45 (1H, q, J=5.4 Hz), 4.84 (2H, s), 7.18 (1H, br s), 7.62 (1Ht, J=1.7 Hz), 7.66 (1H, br s), 7.81 (1H, br s).

Statistics shows that 115-20-8 is playing an increasingly important role. we look forward to future research findings about Trichloroethanol.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; CAPALDI, Carmelida; ARMANI, Elisabetta; JENNINGS, Andrew Steven Robert; HURLEY, Christopher; (82 pag.)US2017/183345; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 115-20-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step A: Synthesis of O-(2,2,2-trichloroethyl) phosphoric dichloride A solution of 52.3 g (0.35 mole) of 2,2,2-trichloroethanol and 53.7 g (0.35 mole) of phosphorous oxychloride in 150 ml of toluene was cooled to -10 C. To this solution, under nitrogen, 27.7 g (0.35 mole) of pyridine was added dropwise while maintaining the temperature at -10 C. Upon completion of addition the temperature was allowed to rise to ambient conditions, and the mixture was stirred overnight. The solid was filtered from the reaction mixture and the toluene evaporated under vacuum. The liquid residue was distilled, yielding the following fractions:

According to the analysis of related databases, 115-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FMC Corporation; US4457923; (1984); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115-20-8, name is Trichloroethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 115-20-8

General procedure: To a stirred solution of tri-O-acetyl-D-galactal (50 mg, 0.185 mmol) in DCM(1 mL) were added the corresponding alcohol (0.204 mmol, 1.1 equiv) andFeCl3·6H2O/C (50 mol%) at ambient temperature. After the reaction was completed(monitored by TLC), the reaction mixture was filtered and the catalystwas washed with dichloromethane. After evaporation of the solvent under vacuum,the crude products were purified by silica gel column chromatography(petroleum ether/EtOAc = 10/1).

The synthetic route of 115-20-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Jiafen; Chen, Heshan; Shan, Junjie; Li, Juan; Yang, Guofang; Chen, Xuan; Xin, Kunyun; Zhang, Jianbo; Tang, Jie; Journal of Carbohydrate Chemistry; vol. 33; 6; (2014); p. 313 – 325;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 115-20-8, Adding some certain compound to certain chemical reactions, such as: 115-20-8, name is Trichloroethanol,molecular formula is C2H3Cl3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115-20-8.

General procedure: Because activation of a carboxylic acid that is adjacent to a chiral center by use of DCC (or EDC) and DMAP can induce epimerization (loss of chiral purity), the condensation reaction between N-protected chiral amino acids (chiral AAs) and the halogenated alcohols is generally performed using a coupling agent (CA) known to minimize or eliminate epimerization (and thereby maintain chiral purity). Generally, such esters were made by reacting the chiral N-protected amino acid (Compound 11 – ) in a suitable solvent such as DCM or DMF by addition of an excess (e.g. 1 .05-5 eq.) of a tertiary organic base such as TEA, NMM or DIPEA and a slight excess (e.g. 1 .1 -1 .3 eq.) of the coupling agent (e.g. HATU or HBTU). A slight excess (e.g. 1 .05 – 1.5 eq.) of the halogenated alcohol was then added and the reaction was monitored by thin layer chromatograph (TLC) until complete. The product was then worked up as discussed in Example 1 , above. Several N-protected esters of chiral amino acids were prepared using this general procedure as summarized in Table 1 B, below, where yield data is also provided.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115-20-8, Trichloroethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TRUCODE GENE REPAIR, INC.; COULL, James, M.; GILDEA, Brian, D.; (182 pag.)WO2018/175927; (2018); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 115-20-8 ,Some common heterocyclic compound, 115-20-8, molecular formula is C2H3Cl3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 38 mg (0.25 mmol) of the required alcohol is added at room temperature to a mixture of 134 mg (0.25 mmol) of acid in 30 ml of DCM, 30.8 mg (0.25 mmol) of DMAP and 49 mg (0.25 mmol) of EDCI. The mixture is stirred for 20 hours at room temperature and is then evaporated todryness. A pasty oil is obtained, which is purified by chromatography (SiO2,2/3 EtOAc/heptane) to give 127 mg (76%) of a pasty product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; WO2006/10423; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 115-20-8, Adding some certain compound to certain chemical reactions, such as: 115-20-8, name is Trichloroethanol,molecular formula is C2H3Cl3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115-20-8.

Example 1 Preparation of intermediate 2, 2, 2-trichloroethyl 4-bromobutyrate A stirred solution of 4-bromobutyric acid (3.34 g, 20.0 mmol) in toluene (50 ml) was added 2,2, 2-trichloroethanol (14.94 g, 0.10 mol) and p-toluenesulfonic acid monohydrate (7.60 g, 40.0 mmol) and refluxed with a Dean-Stark trap attached for 6 h. Water was removed continuously. The reaction mixture was cooled to room temperature and concentrated in vacuo. The mixture was added CH2CI2 (75 ml) and washed with H2O (3 x 25 ml). The organic layer was dried over Na2SO4, filtered and evaporated in vacuo to leave an oil. The residue was distilled to leave the title compound as a colourless oil (4.77 g, 79.9 %) (bp 100 C at 0.5 mmHg). tH-NMR (300 MHz, CDCl3) : 5 4.74 (s, 2H), 3.48 (t, 2 H), 2.65 (t, 2 H), 2.21-2. 13 (m, 2 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115-20-8, Trichloroethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIO-MEDISINSK INNOVASJON AS; WO2005/61483; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.SDS of cas: 115-20-8

A mixture of CLTAM (1.0 g, 2.59 mmol) and K2C03 (0.39 g, 2.85 mmol) in 2.2,2-trichloroethanol (5 mL) was stirred at room temperature for 16 hours. Water (70 mL) was added, then product was extracted to MeTHF (3 x 20 mL), combined organic layers ware dried over MgS04, and then concentrated to afford crude product, which was purified by chromatography (Si02, hexane:EtOAc) to afford title compound as white powder (1.00 g, 78% yield). MP 1 18C; MS (ESI) mlz: 498 [MH]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,115-20-8, Trichloroethanol, and friends who are interested can also refer to it.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; ZUPANCIC, Borut; MARAS, Nenad; STERK, Damjan; WO2013/60837; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 115-20-8

1. t-BOC-L-Alanine 2,2,2-Trichloroethyl Ester t-BOC-L-Alanine was treated with N,N’-carbonyldiimidazole in DMF followed by 2,2,2-trichloroethanol. After the reaction was complete the solvent was removed, the residue dissolved in EtOAc and the EtOAc layer washed with water, dilute hydrochloric acid and 5% sodium bicarbonate. The EtOAc layer was dried with magnesium sulfate then evaporated to give the product.

With the rapid development of chemical substances, we look forward to future research findings about 115-20-8.

Reference:
Patent; Mallinckrodt, Inc.; US4406832; (1983); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 115-20-8

1. t-BOC-L-Alanine 2,2,2-Trichloroethyl Ester t-BOC-L-Alanine was treated with N,N’-carbonyldiimidazole in DMF followed by 2,2,2-trichloroethanol. After the reaction was complete the solvent was removed, the residue dissolved in EtOAc and the EtOAc layer washed with water, dilute hydrochloric acid and 5% sodium bicarbonate. The EtOAc layer was dried with magnesium sulfate then evaporated to give the product.

With the rapid development of chemical substances, we look forward to future research findings about 115-20-8.

Reference:
Patent; Mallinckrodt, Inc.; US4406832; (1983); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts