With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.SDS of cas: 115-20-8
A mixture of CLTAM (1.0 g, 2.59 mmol) and K2C03 (0.39 g, 2.85 mmol) in 2.2,2-trichloroethanol (5 mL) was stirred at room temperature for 16 hours. Water (70 mL) was added, then product was extracted to MeTHF (3 x 20 mL), combined organic layers ware dried over MgS04, and then concentrated to afford crude product, which was purified by chromatography (Si02, hexane:EtOAc) to afford title compound as white powder (1.00 g, 78% yield). MP 1 18C; MS (ESI) mlz: 498 [MH]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,115-20-8, Trichloroethanol, and friends who are interested can also refer to it.
Reference:
Patent; LEK PHARMACEUTICALS D.D.; ZUPANCIC, Borut; MARAS, Nenad; STERK, Damjan; WO2013/60837; (2013); A1;,
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