Reference of 76066-27-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 76066-27-8, name is 1-(Aminomethyl)cyclopentanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.
Step A. 1-{[(4-Bromo-2-nitrophenyl)amino]methyl}cyclopentanol The mixture of 2,5-dibromonitrobenzene (Tokyo Kasei Kogyo Co., Ltd., 5.4 g, 19.2 mmol), 1-(aminomethyl)cyclopentanol hydrochloride (J. Med. Chem. 1981, 24, 12-16, 4.3 g, 28.4 mmol) and N,N-diisopropylethylamine (8.4 mL, 48.1 mmol) in 1-methyl-2-pyrrolidinone (32 mL) was microwaved for 30 min at 200 C. The reaction was quenched with water and extracted three times with ethyl acetate. The combined organic layers were dried over sodium sulfate and filtered. The filtrate was concentrated and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=5:1 as eluent) to afford the title compound (2.6 g, 43%) as an orange amorphous solid. 1H-NMR (CDCl3) delta: 8.36 (br s, 1H), 8.32 (d, J=2.2 Hz, 1H), 7.49 (dd, J=8.8, 2.2 Hz, 1H), 6.83 (d, J=9.5 Hz, 1H), 3.40 (d, J=5.1 Hz, 2H), 1.96-1.67 (m, 8H), a peak of OH was not identified. MS (ESI) 315 (M+H)+, 313 (M-H)-.
According to the analysis of related databases, 76066-27-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kon-I, Kana; Matsumizu, Miyako; Shima, Akiko; US2006/94750; (2006); A1;,
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