Category: 3250-73-5

Reference of 3250-73-5, Adding some certain compound to certain chemical reactions, such as: 3250-73-5, name is 2-(2-Ethoxyphenoxy)ethanol,molecular formula is C10H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3250-73-5.

To a solution of (ether)benzoxy alcohol 20A (501.2 mg, 2.751 mmol) in CH2Cl2 (20 mL) was added Et3N (509 mg, 5.03 mmol) and toluenesulfonyl chloride (623 mg, 3.27 mmol) at 5-10 C. After being stirred at 25 C for 30 min, the reaction mixture was quenched with saturated aqueous Na2CO3 (20 mL) and extracted with ethyl acetate (3 × 50 mL). The combined organic layers were dried over MgSO4(s), filtered, and concentrated under reduced pressure to obtain (ether)benzoxy tosylate 21A (853.5 mg, 2.539 mmol) as white solids in 92 % yield: mp (recrystallized from CH2Cl2 and CCl4) 82-83 C; 1H NMR (CDCl3, 300 MHz) delta 1.43 (t, J = 10.2 Hz, 3 H, OCH2CH3), 2.51 (s, 3 H, ArCH3), 4.04 (q, J = 10.2 Hz, 2 H, OCH2CH3), 4.36 (t, J = 6.9 Hz, 2 H, OCH2CH2), 4.59 (t, J = 6.9 Hz, 2 H, OCH2CH2), 6.86-6.97 (m, 4 H, ArH), 7.10-7.22 (m, 4 H, ArH); IR (neat) 3446 (br), 2982 (m), 2934 (m), 2884 (m), 1591 (s), 1558 (w), 1509 (s), 1478 (s), 1454 (s), 1407 (s), 1394 (s), 1371 (s), 1354 (s), 1279 (m), 1259 (s), 1247 (s), 1217 (s), 1178 (s), 1127 (s), 1066 (s), 1043 (s), 1031 (s), 977 (s), 929 (s), 905 (s), 809 (s), 776 (m), 749 (s), 776 (m) cm-1

According to the analysis of related databases, 3250-73-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Well-being Biochemical Corp.; Taiwan Biotech Co., Ltd.; EP1734036; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3250-73-5 , The common heterocyclic compound, 3250-73-5, name is 2-(2-Ethoxyphenoxy)ethanol, molecular formula is C10H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Afterthe pyridine (200ml) was added to obtained 2 – (2- ethoxyphenoxy) ethanols (50.0g,0.274mol, 1.0eq) at 1 step and it altogether dissolved it cooled at 0. Methanesulfonyl chlorides(35.0ml, 0.453mol, 1.65eq) were dipped from the gradually to the cooledsolution and it was stirred for 1 hour while it heated to the slowly to the room temperature (20). The solid which wasgenerated after it dipped the water (350ml) as the gradually after it cooledthe above-mentioned stirred solution at 0 was filtered and 2 – (2- ethoxyphenoxy) ethylmethane sulfonate was obtained (62g, and the yield 87%). 2-(2-) NMR . Theobtained NMR peak of 2 – (2- ethoxyphenoxy) ethyl methane sulfonate showed uplike the next.

The synthetic route of 3250-73-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boryung Pharmaceutical Co., Ltd; Kim, Ji Han; Myung, Jae Hyok; Lee, Jun Kwang; Sun, Yong Ho; Kim, Hak Do; (20 pag.)KR101525493; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 3250-73-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3250-73-5 as follows.

EXAMPLE 9 To a solution of (ether)benzoxy alcohol 20A (501.2 mg, 2.751 mmol) in CH2Cl2 (20 mL) was added Et3N (509 mg, 5.03 mmol) and toluenesulfonyl chloride (623 mg, 3.27 mmol) at 5-10 C. After being stirred at 25 C. for 30 min, the reaction mixture was quenched with saturated aqueous Na2CO3 (20 mL) and extracted with ethyl acetate (3*50 mL). The combined organic layers were dried over MgSO4 (s), filtered, and concentrated under reduced pressure to obtain (ether)benzoxy tosylate 21A (853.5 mg, 2.539 mmol) as white solids in 92% yield: mp (recrystallized from CH2Cl2 and CCl4) 82-83 C.; 1H NMR (CDCl3, 300 MHz) delta 1.43 (t, J=10.2 Hz, 3 H, OCH2CH3), 2.51 (s, 3 H, ArCH3), 4.04 (q, J=10.2 Hz, 2 H, OCH2CH3), 4.36 (t, J=6.9 Hz, 2 H, OCH2CH2), 4.59 (t, J=6.9 Hz, 2 H, OCH2CH2), 6.86-6.97 (m, 4 H, ArH), 7.10-7.22 (m, 4 H, ArH); IR (neat) 3446 (br), 2982 (m), 2934 (m), 2884 (m), 1591 (s), 1558 (w), 1509 (s), 1478 (s), 1454 (s), 1407 (s), 1394 (s), 1371 (s), 1354 (s), 1279 (m), 1259 (s), 1247 (s), 1217 (s), 1178 (s), 1127 (s), 1066 (s), 1043 (s), 1031 (s), 977 (s), 929 (s), 905 (s), 809 (s), 776 (m), 749 (s), 776 (m) cm-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3250-73-5, its application will become more common.

Reference:
Patent; Jih, Ru Hwu; Tsay, Shwu Chen; Magendran, Balaachary; Chakraborty, Subhasish K.; Das, Asish R.; Sheu, Kuen Wang; Shu, Chun Mei; Lu, Chin Kun; Chang, Wei Min; US2007/15939; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts