Category: 101597-25-5

Electric Literature of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Comparative Example 1 3,3-Dianisyl-3H-naphtho[2,1-b]pyran. A mixture of 2-naphthol (3.23 g;0.0224 mol), 1,1-dianisylprop-2-yn-1-ol (6.00 g;0.0224 mol), acidic alumina Brockmann 1(6 g) and toluene (250 ml) was heated and stirred for 1.5 h, cooled, filtered and the solid washed with toluene. The filtrate was evaporated to give a pale purple tacky solid which was washed with pet. ether (40-60)/diethyl ether to yield crude product (7.07 g). Purification of the solid by crystallisation from ethylacetate gave 3,3-dianisyl-3H-naphtho[2,1-b]pyran as a white solid (5.52 g;66% yield), m.pt 176-177 C. STR10

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pilkington PLC; US5520853; (1996); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: 101597-25-5

10244] A propargyl alcohol compound represented by thefollowing formula was provided. 10245] 1.55 Grams (4.0 mmols) of the indenonaphthol compound obtained in Example 4 and 1.40 g (5.2 mmols) of the above propargyl alcohol compound were dissolved in 47 ml of toluene and to which was, further, added 0.03 g of camphorsulfonic acid to conduct the reaction at 100 C. for one hour.10246] After the reaction, the solvent was removed, the reaction product was refined by chromatography (solvent chloroform) using silica gel and was, thrther, recrystallized with acetonitrile to obtain 1.86 g (2.9 mmols) of a white solid material of an indenonaphthopyran represented by the following formula (ES). The yield was 73%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TOKUYAMA CORPORATION; IZUMI, Shinobu; TERANISHI, Kazuhiro; (26 pag.)US2016/130203; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

A 500 mL three-necked flask equipped with a water trap was charged with 1-hydroxypyrene (Ea0,623 mg, 2.85 mmol), a propargyl alcohol derivative (E0, 903 mg, 3.36 mmol)3.5g of acidic alumina and 300mL of toluene, under argon protection, dark reaction 90 C for 35h, the solution was dark green.After cooling to room temperature, the reaction mixture was suction filtered, the filter cake was washed with dichloromethane, the filtrate and the washings were combined, the solvent was spin dried,The crude product was separated by column chromatography, and the resulting crude product was recrystallized from absolute ethanol to give 210 mg of a light yellow solid in a yield of 22%. Yield 55%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Gantian Optical Materials Co., Ltd.; Gan Jiaan; (9 pag.)CN104016996; (2017); B;,
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Synthetic Route of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

2-Phenylthio-1,4-dihydroxynaphthalene (2 g) from Step 1 and 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (2.25 g) from Step 2 of Example 1 were added to a reaction flask containing 70 ml of toluene and stirred at room temperature. A catalytic amount of p-toluenesulfonic acid (about 100 mg) was added and stirred for 4 hours under a nitrogen atmosphere. Afterwards, the reaction mixture was poured into 50 ml of 10 weight percent aqueous sodium hydroxide solution. The organic layer was separated, washed and dried over anhydrous sodium sulfate. Evaporation of solvent resulted in an oily product which was purified using a silica gel column and a 1:1 mixture of chloroform:hexane as the eluant. The photochromic fractions were combined and the eluant was removed under vacuum. The resulting product was induced to crystallize from diethyl ether. The recovered product (2.5 g) had a melting point of 152-154C. A nuclear magnetic resonance (NMR) spectrum showed the product to have a structure consistent with 2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran.

Statistics shows that 101597-25-5 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; EP994871; (2006); B1;,
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Synthetic Route of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.

Preparation of 2-(2-(2-(2-(4-(hydroxybis(4-methoxyphenyl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethanol (5d) The following are added to 100 mL of DCM/H2O mixture (1/1): 3 (1.988 g; 9.07 mmol; 1 eq.), 4d prepared according to Gabbutt, C. D.; Heron, B. M.; Instone, A. C.; Thomas, D. A. Partington, S. M.; Hursthouse, M. B.; Gelbrich, T. Eur. J. Org. Chem. 2003, 7, 1220; (2.379 g; 9.07 mmol; 1 eq.) and CuBr (0.260 g; 1.814 mmol; 0.2 eq.). The solution is stirred vigorously for 20 h and extracted with DCM and washed with a saturated solution of NH4Cl. The organic phase is dried (MgSO4), filtered and concentrated under vacuum. The crude product is purified (flash chromatography, silica gel, eluent DCM/MeOH) to give 5d in the form of an oil (3.463 g; 7.19 mmol; 79%). Rf (SiO2, DCM/MeOH (95/5)): 0.15,

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; INSERM (Institut National de la Sante et de la Recherche Medicale); Bertrand, Philippe; Delatouche, Regis; Heroguez, Valerie; Collette, Floraine; Gregoire, Marc; Blanquart, Christophe; Gueugnon, Fabien; US2014/219925; (2014); A1;,
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Reference of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.

Step 6; To the product in toluene from Step 5, 1 )1 -bis{4~methoxypr¾enyl)prop-2-yn-1 -ol {0.8 g), a few crystals of p-toiuene sulfonic acid were added. After stirring for one hour at room temperature, all the solvent was. evaporated. The recovered product was purified by ComfaiFlash followed by re-crystailization. from diethyl ether. White crystals {0.95 g) were obtained as the product. NMR indicated that the product had a structure consistent with 3,3- bis(4-rrtethoxyphenyl)~l 0, 12-dibromo-6,7-dimethoxy-11 ,13, 13-trimethyl-3H,l 3H- indeno^’.^^jnaphthop ,2-b]pyran as represented by the following graphic formula.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; WO2012/82506; (2012); A1;,
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Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(synthesis of chromene compound) [0128] 1.18 g (2.0 mmol) of the above naphthol compound (15) and 0.81 g (3.0 mmol) of the following propargyl alcohol compound were dissolved in 50 ml of toluene, and 0.02 g of camphorsulfonic acid was added to the resulting solution and stirred under heating and reflux for 1 hour. After a reaction, the solvent was removed, and the obtained reaction product was purified by chromatography on silica gel to obtain 1.17 g of a white powder product. The yield was 70 %. [0129] The elemental analysis values of this product were 84.59 % of C and 5.93 % of H which were almost equal to the calculated values of C59H50O5 (C: 84.46 %, H: 6.01 %). [0130] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 20H peaks based on a methyl proton and a methylene proton at delta of around 1.0 to 4.0 ppm and 30H peaks based on an aromatic proton and an alkene proton at delta of around 5.5 to 9.0 ppm. [0131] Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm, and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0132] It was confirmed from the above results that the isolated product was a compound represented by the following formula (E1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tokuyama Corporation; IZUMI, Shinobu; TERANISHI, Kazuhiro; DAIKOKU, Yusuke; SANDO, Mitsuyoshi; EP2725017; (2014); A1;,
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Reference of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Compound 6 (100g, 0.41mol, 1eq), compound 8 (87g, 0.8eq) and Al2O3 (415g, 10eq) was put inside the reactor (connected with Dean-Stock device) containing toluene (3L). The reaction mixture was deoxygenized with the stream of nitrogen gas followed by refluxing the reaction mixture. On completion, the reaction mixture was cooled to room temperature, washed with NaOH solution and removed the toluene on rotary. After that solid product was mixed with ethyl acetate: water and organic layer was separated, removed excess solvent on rotary to afford 9 which was purified by column chromatography using hexane: ethyl acetate: toluene (5:1:1) solvent system. Fine yellow crystals of 9 were collected on mixing it with ethyl acetate [32-38]. 1H NMR (CDCl3, ppm): delta 3.09 (s, 6H), 3.76 (s, 6H), 3.9 (s, 3H), 6.09 (d, 1H), 6.79 (d, 4H), 7.05 (dd, 1H), 7.25 (d, 1H), 7.35 (d, 4H), 7.60 (dd, 2H), 7.95 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Moon-Hwan; Saleem, Muhammad; Seo, Ji-Su; Choi, Chang-Shik; Lee, Ki Hwan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1291 – 1297;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

Example 1; 1.15 g (2.33 mmol) of a naphthol compound represented by the following formula (15) and 0.92 g (3.43 mmol) of a propargyl alcohol compound represented by the following formula (16) were dissolved in 50 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added, and the obtained mixture was refluxed for 1 hour. After the reaction, the solvent was removed, the obtained product was purified by column chromatography, and crystallization was carried out with methanol (5 ml) to obtain 1.21 g of a white powder (yield rate of 70 %). The elemental analysis values of this product were 75.66 % of C, 6.44 % of H and 3.71 % of N which were almost equal to the calculated values of C47H47F3N2O3 (C: 75.78 %, H: 6.36 %, N: 3.76 %). When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 31H peaks based on an alkyl group and an alkoxy group at delta of around 0.5 to 4.5 ppm and a 16H peak based on an aromatic proton at delta of around 5.0 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm and peaks based on the carbons of an alkyl group and an alkoxy group at delta of around 10 to 80 ppm. It was confirmed from the above results that the isolated product was a compound represented by the following formula (17).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tokuyama Corporation; EP2457915; (2012); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C17H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3

General procedure: A solution of the naphthol (1 mol equiv) and the appropriate 1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol (1 mol equiv), in the presence of pyridinium p-toluenesulfonate (PPTS) (5 mole %) and trimethyl orthoformate (2 mol equiv) in 1,2-dichloroethane (150 mL),was heated under reflux for up to 4 h (the reaction time being determined by TLC examination of the reaction mixture). The cooled solvent was removed under vacuum to afford the crude product, which was either purified by flash column chromatography or by crystallisation. The following compounds were obtained in this manner: 4.8.1. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9 from 7 and 8 as pale pink microcrystals after crystallisation from EtOAc and hexane, 52.4%, mp 188 – 190C; upsilonmax 2831, 1651, 1606, 1506, 1351, 1236, 1173, 1028, 1017, 876, 836, 726, 706, 683, 663, 646 cm-1; deltaH (CDCl3) 3.76 (6H, s, OMe), 6.13 (1H, d, J9.9 Hz, 5-H), 6.82 e6.85 (4H, m, AreH), 7.44 e7.47 (4H, m, AreH),7.51 e7.65 (6H, m, AreH, 4-H), 7.93 e7.95 (2H, m, Ar eH), 8.02 (1H, s,2-H), 8.19 (1H, d, J 7.8 Hz, Ar eH), 8.45 (1H, d, J 8.1 Hz, AreH); deltaC(CDCl3) 55.22, 82.22, 110.56, 113.38, 117.80, 119.99, 121.17, 122.83,123.08, 123.64, 124.09, 125.90, 127.09, 127.11, 128.28, 128.62, 129.67,132.92, 137.34, 139.29, 145.27, 147.04, 151.68, 158.84, 190.48 (Found M+H+, 539.1844; C36H26O5 requires M+H+, 539.1853).

The synthetic route of 101597-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aiken, Stuart; Allsopp, Ben; Booth, Kathryn; Gabbutt, Christopher D.; Heron, B. Mark; Rice, Craig R.; Tetrahedron; vol. 70; 49; (2014); p. 9352 – 9358;,
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