Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(synthesis of chromene compound) [0128] 1.18 g (2.0 mmol) of the above naphthol compound (15) and 0.81 g (3.0 mmol) of the following propargyl alcohol compound were dissolved in 50 ml of toluene, and 0.02 g of camphorsulfonic acid was added to the resulting solution and stirred under heating and reflux for 1 hour. After a reaction, the solvent was removed, and the obtained reaction product was purified by chromatography on silica gel to obtain 1.17 g of a white powder product. The yield was 70 %. [0129] The elemental analysis values of this product were 84.59 % of C and 5.93 % of H which were almost equal to the calculated values of C59H50O5 (C: 84.46 %, H: 6.01 %). [0130] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 20H peaks based on a methyl proton and a methylene proton at delta of around 1.0 to 4.0 ppm and 30H peaks based on an aromatic proton and an alkene proton at delta of around 5.5 to 9.0 ppm. [0131] Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm, and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0132] It was confirmed from the above results that the isolated product was a compound represented by the following formula (E1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Tokuyama Corporation; IZUMI, Shinobu; TERANISHI, Kazuhiro; DAIKOKU, Yusuke; SANDO, Mitsuyoshi; EP2725017; (2014); A1;,
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