Electric Literature of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of 3,6,11-trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, methyl ester (17) To a stirred solution of 2-(2-aminoethoxyl)ethanol (1.05 g, 10 mmol, 1 equiv) in anhydrous ethanol (15 mL) at 0 C. was added di-tert-butyl dicarbonate (2.2 g, 10 mmol, 1 equiv). The reaction mixture was stirred for 2 hours at room temperature. It was concentrated under reduced pressure, re-dissolved in dichloromethane, and washed with brine. The organic extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to give the crude product as a colorless oil. The product 12 was used in the next step without further purification. 1H NMR (600 MHz, CDCl3) delta 1.44 (s, 9H), 3.33-3.34 (m, 2H), 3.54-3.59 (dt, J=10.4, 5.2 Hz, 2H), 3.73-3.75 (dt, J=4.3, 3.4 Hz, 2H).
The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF TOLEDO; Tillekeratne, L. M. Viranga; Almaliti, Jehad; Al-Hamashi, Ayad; Bhansali, Pravin; (74 pag.)US2015/329560; (2015); A1;,
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