Category: 22419-35-8

Application of 22419-35-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22419-35-8, name is 4,4-Difluorocyclohexanol, molecular formula is C6H10F2O, molecular weight is 136.1398, as common compound, the synthetic route is as follows.

To a solution of 4,4-difluorocyclohexanol (0.9 g) in toluene was added triphenyl phosphine (2.6 g) and di-t-butyldiazacarboxalate (1.82 g) and the reaction mixture stirred for 18 h. The reaction mixture was concentrated and methanol was added (13 mL). To the methanol solution HCl in dioxane (4M, 13 mL) was added. The reaction mixture was stirred for 3 h and concentrated. The reaction mixture was partitioned between water and ethyl acetate. The layers were separated and the aqueous layer was extracted 3* with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered and concentrated. The title compound was used without purification in the preparation of 5-amino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile. 400 MHz 1H NMR (CD3OD) delta 2.15-2.07 (m, 4H), 2.00-1.81 (m, 2H), 1.68-1.58 (m,2H). (M+H m/z=279.0).

The chemical industry reduces the impact on the environment during synthesis 22419-35-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pfizer Inc; US2009/30003; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22419-35-8, name is 4,4-Difluorocyclohexanol, molecular formula is C6H10F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4,4-Difluorocyclohexanol

To a stirred suspension of (RS)-3-(4-isocyanato-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (110 mg) in THF (1 ml) were added sequentially N,N-diisopropylethylamine (0.13 ml) and 4,4-difluorocyclohexanol (68 mg, CAS 22419-35-8) and the mixture was heated at 110¡ã C. for 18 h. The mixture was then concentrated in vacuo and the residue was purified by column chromatography (SiO2; gradient: heptane/EtOAc) to give (RS)-3-[4-(4,4-difluoro-cyclohexyloxycarbonylamino)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (20 mg, 12percent) as an off-white solid. MS (ISP): 447.4 ([M+Na]+), 442.4 ([M+NH4]+), 369.2 ([M+H-C4H8]+).

With the rapid development of chemical substances, we look forward to future research findings about 22419-35-8.

Reference:
Patent; Groebke Zbinden, Katrin; Norcross, Roger; Pflieger, Philippe; US2011/152245; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts