Category: 3597-91-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. Safety of [1,1′-Biphenyl]-4-ylmethanol

Synthesis of 4-(bromomethyl)biphenylCarbon tetrabromide (8.99 g) and triphenylphosphine (7.11 g) were added to a stirred solution of biphenyl-4-yl-methanol (5.00 g) in dichloromethane (100 ml) at room temperature and stirrred the reaction mixture for approximately 2 hours at the same temperature. The solvent was evaporated under reduced pressure and the residue thus obtained was purified by column chromatography using 5% diethylether in hexane as eluant to furnish the title compound (6.37 g).

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Palle, Venkata P.; Sattigeri, Viswajanani Jitendra; Khera, Manoj Kumar; Voleti, Sreedhara Rao; Ray, Abhijit; Dastidar, Sunanda G.; US2008/194565; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3597-91-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3597-91-9

General procedure: To a Schlenk tube were added Fe(NO3)3·9H2O (40.6 mg, 0.1 mmol), TEMPO (15.8 mg, 0.1 mmol), KCl (7.5 mg, 0.1 mmol), 1a (108.5 mg, 1.0 mmol), and DCE (4.0 mL) sequentially under an atmosphere of oxygen (gas bag, commercial size: 2 L, which could be expanded to 5 L). The mixture was then stirred at 25 C until completion of the reaction as monitored by TLC (petroleum ether/EtOAc = 5:1) (48h). The crude reaction mixture was filtered through a short column of silica gel (height: 2 cm, diameter: 3 cm) eluting with Et2O (3 × 25 mL). After evaporation, the residue was purified by chromatography on silica gel [petroleum ether/EtOAc = 15:1 (500 mL) to 2:1 (300 mL)] to afford benzoic acid (2a)14 (69.9 mg, 57%) as a pale yellow solid. Yields of 57% of 2a and 38% of benzaldehyde (3a)15 were observed by NMR analysisof the crude product using CH2Br2 as an internal standard and by comparison with spectra reported in the literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Jiang, Xingguo; Ma, Shengming; Synthesis; vol. 50; 8; (2018); p. 1629 – 1639;,
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Related Products of 3597-91-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

Statistics shows that 3597-91-9 is playing an increasingly important role. we look forward to future research findings about [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
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Application of 3597-91-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. A new synthetic method of this compound is introduced below.

General procedure: To a solution of 1-(p-bromophenyl)ethanol I-23 (201 mg, 1.0 mmol) in DMF (2.0 mL) was added HIO3 (194 mg, 1.1 mmol) and TEMPO (7.8 mg, 0.05 mmol). The mixture was stirred for 2 h at room temperature under an Ar atmosphere. After the reaction, the reaction mixture was poured into aq Na2S2O3, and extracted with a mixture of Et2O: hexane=1:1 (3*10 mL). Then, the organic layer was poured into satd NaCl (10 mL) and extracted with Et2O (10 mL). The organic layer was dried over Na2SO4. After being filtration and removal of the solvent under reduced pressure, the residue was purified by flash short column chromatography on silica gel (EtOAc-hexane, 1:4) to give p-bromoacetophenone II-23 in 99% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Imai, Sho; Togo, Hideo; Tetrahedron; vol. 72; 44; (2016); p. 6948 – 6954;,
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Reference of 3597-91-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Carbon tetrabromide (8.99 g) and triphenylphosphine (7.11 g) were added to a stirred solution of biphenyl-4-yl-methanol (5.00 g) in dichloromethane (100 ml) at room temperature and stirrred the reaction mixture for approximately 2 hours at the same temperature. The solvent was evaporated under reduced pressure and the residue thus obtained was purified by column chromatography using 5% diethylether in hexane as eluant to furnish the title compound (6.37 g) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2006/90235; (2006); A1;,
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Application of 3597-91-9, Adding some certain compound to certain chemical reactions, such as: 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol,molecular formula is C13H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3597-91-9.

A mixture of K2CO3 (1 mmol) and the catalyst (52 mg, ?3 mol% of Pd2+) in toluene (5 ml) was prepared in a two necked flask. The flask was evacuated and refilled with pure oxygen. To this solution, the alcohol (1 mmol, in 1 ml toluene) was injected and the resulting mixture was stirred at 80 C under an oxygen atmosphere. After completion of reaction, the reaction mixture was filtered off and the catalyst rinsed twice with CH2Cl2 (5 ml). The excess of solvent was removed under reduced pressure to give the corresponding carbonyl compounds.

According to the analysis of related databases, 3597-91-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Alizadeh; Khodaei; Kordestania; Beygzadeh; Journal of Molecular Catalysis A: Chemical; vol. 372; (2013); p. 167 – 174;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. Formula: C13H12O

In the glove box,Mn(CO)5Br (0.005 mmol),[(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridine] (0.006 mmol),Add 1.0 mL of toluene, stir for two hours, add 2-methylquinoline 4 (2 mmol),2 g (1 mmol), after reacting at 135 C for 48 hours, the reaction was stopped and the solvent was evaporated., column chromatography ethyl acetate / petroleum ether (1:10),The trans-disubstituted olefin derivative 3ag. The product was a white solid with a yield of 92%.

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Qingdao University of Science and Technology; Zhang Chunyan; (19 pag.)CN108250153; (2018); A;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.Application In Synthesis of [1,1′-Biphenyl]-4-ylmethanol

General procedure: To a flask that was charged with the benzyl alcohol (10 mmol), triethylamine (20 mmol) in THF (25 mL) cooled at 0 C, was added mesyl chloride (20 mmol) in THF (50 mL) over half an hour. Then the mixture was allowed to stir at room temperature for about 20-30 min. Cold water was added to the mixture, then the mixture was extracted with diethyl ether (125 mLx1). Triethylamine (5 mol) was added into the crude product solution to remove the unreacted mesyl chloride. Then the solution was washed with saturated aqueous NaHCO3 (10 mL), cold water (25 mL) and brine (25 mL). The solution was dried over anhydrous Na2SO4. Removal of the solvent under reduced pressure gave the benzyl mesylate products, which are used in the coupling reaction without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Wu, Guojiao; Xu, Shuai; Deng, Yifan; Wu, Chaoqiang; Zhao, Xia; Ji, Wenzhi; Zhang, Yan; Wang, Jianbo; Tetrahedron; vol. 72; 49; (2016); p. 8022 – 8030;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. A new synthetic method of this compound is introduced below., COA of Formula: C13H12O

General procedure: p-Nitrobenzyl alcohol (0.25 g, 1.63 mmol) was dissolved in anhydrous CH2Cl2 under N2. Triethylamine (0.227 mL, 1.63 mmol) was added and the resulting solution was cooled to 0 C. S2Cl2 (65.3 muL, 0.82 mmol) was added dropwise over 20 min. The solution was stirred at 0 C for 2 h before being allowed to equilibrate to room temperature for 3 h. The reaction was quenched with dH20, washed with 2 × 20 mL aliquots of brine. The aqueous phase was extracted with CH2Cl2 (2 × 10 mL), and the combined organic was dried over MgSO4, filtered, and concentrated under reduced pressure. Column chromatography with a 2.5:1 ratio of hexanes:ethyl acetate afforded:

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Article; Stoutenburg, Eric G.; Palermo, Anne E.; Priefer, Ronny; Thermochimica Acta; vol. 551; (2013); p. 99 – 103;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 3597-91-9

(A) 4-Phenylbenzyl Bromide Triphenylphosphine (1.58 g) and N-bromosuccinimide (1.07 g) were added to a stirred solution of 4-hydroxymethylbiphenyl (1.01 g) in dichloromethane (10 mL) under nitrogen. The mixture was stirred at room temperature for 15 hr and evaporated in vacuo. The residue was diluted with chloroform, and washed with saturated sodium hydrogencarobonate, and brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:100 to 1:50, v/v) to give the titled compound (1.26 g) as colorless crystals: 1H-NMR (400 MHz, CDCl3) delta 4.55 (s, 2H), 7.33-7.38 (m, 1H), 7.41-7.49 (m, 4H), and 7.54-7.60 (m, 4H).

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Microcide Pharmaceuticals, Inc.; US6399629; (2002); B1;,
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