Category: 93524-95-9

《Palladium-catalyzed coupling reaction of halo heteroaromatic compounds in waterã€?was written by Inoue, Naoki; Sugimoto, Osamu; Tanji, Ken-ichi. Category: alcohols-buliding-blocks And the article was included in Heterocycles on April 13 ,2007. The article conveys some information:

Palladium-catalyzed coupling reaction of π-deficient heteroaromatic halides with terminal alkynes in water was accomplished with excellent to good yields without any side reactions such as hydrolysis. The experimental process involved the reaction of 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Category: alcohols-buliding-blocks)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zubar, Viktoriia; Sklyaruk, Jan; Brzozowska, Aleksandra; Rueping, Magnus published an article in Organic Letters. The title of the article was 《Chemoselective Hydrogenation of Alkynes to (Z)-Alkenes Using an Air-Stable Base Metal Catalyst》.Recommanded Product: 93524-95-9 The author mentioned the following in the article:

A highly selective hydrogenation of alkynes using an air-stable and readily available manganese catalyst has been achieved. The reaction proceeds under mild reaction conditions and tolerates various functional groups, resulting in (Z)-alkenes and allylic alcs. in high yields. Mechanistic experiments suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperativity. In the experiment, the researchers used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Recommanded Product: 93524-95-9)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 93524-95-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Usuki, Toyonobu; Komatsu, Akira published an article in Tetrahedron Letters. The title of the article was 《Preparation of monoalkylpiperidines via the mild hydrogenation of monoalkynylpyridines》.Recommanded Product: 93524-95-9 The author mentioned the following in the article:

Monoalkynylpyridines were prepared via a Sonogashira cross-coupling reaction between monoiodopyridines and alkynes. From the obtained monoalkynylpyridines, mild hydrogenation was conducted to produce the corresponding monoalkylpiperidines in moderate to excellent yields. The hydrogenation reaction was carried out under H2(1 atm) in the presence of 10 wt% Pd/C (5 equiv) in either AcOH or MeOH at room temperature Therefore, this mild method was useful for the quick and easy preparation of monoalkylpiperidines. The results came from multiple reactions, including the reaction of 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Recommanded Product: 93524-95-9)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 93524-95-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3-(4-Pyridyl)-2-propyn-1-olOn March 7, 2005, Feuerstein, Marie; Doucet, Henri; Santelli, Maurice published an article in Tetrahedron Letters. The article was 《Sonogashira cross-coupling reactions with heteroaryl halides in the presence of a tetraphosphine-palladium catalyst》. The article mentions the following:

Heteroaryl halides undergoes cross-couplings with alkynes in good yields in the presence of [PdCl(C3H5)]2/cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as catalyst. A variety of heteroaryl halides such as pyridines, quinolines, a pyrimidine, an indole, a thiophene, or a thiazole were used successfully. The reaction also tolerates several alkynes such as phenylacetylene and a range of alk-1-ynols. Furthermore, this catalyst can be used at low loading with some substrates. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Safety of 3-(4-Pyridyl)-2-propyn-1-ol) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-(4-Pyridyl)-2-propyn-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sitte, Nikolai A.; Ghiringhelli, Francesca; Shevchenko, Grigory A.; Rominger, Frank; Hashmi, A. Stephen K.; Schaub, Thomas published an article in Advanced Synthesis & Catalysis. The title of the article was 《Copper-Catalysed Synthesis of Propargyl Alcohol and Derivatives from Acetylene and other Terminal Alkynes》.Computed Properties of C8H7NO The author mentioned the following in the article:

A copper(I)/phosphine system that homogeneously catalyzed the alkynylation of formaldehyde with acetylene or terminal alkynes to afford propargyl alc. and derivatives RCCCH2OH [R = Ph, 4-MeOC6H4, 3-HOC6H4, etc.] was reported. Using acetylene at atm. pressure, the catalyst consisting of <1 mol% copper(I) phenylacetylide and a trialkyl bisphosphine ligand showed a high selectivity toward the formation of propargyl alcs. rather than 1,4-butynediol, which was not reported for common heterogeneous copper acetylide catalysts. The biphasic water/toluene reaction mixture allowed the separation of targeted products with the aqueous layer and catalyst recycling via the organic layer. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Computed Properties of C8H7NO) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C8H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaghafi, Michael B.; Barrett, David G.; Willard, Francis S.; Overman, Larry E. published an article on February 15 ,2014. The article was titled 《The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 93524-95-9 The information in the text is summarized as follows:

We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, I.HCl, II.HCl and III.HCl, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of IV.HCl, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. In the experimental materials used by the author, we found 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9SDS of cas: 93524-95-9)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 93524-95-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3-(4-Pyridyl)-2-propyn-1-olOn March 7, 2004, Kim, Nakjoon; Kim, Ki Seong; Gupta, Aruna Kumar; Oh, Chang Ho published an article in Chemical Communications (Cambridge, United Kingdom). The article was 《On the regioselectivity of Pd-catalyzed additions of organoboronic acids to unsymmetrical alkynes》. The article mentions the following:

The Pd-catalyzed addition of organoboronic acids to unsym. alkynes gave a regioisomeric mixture of trisubstituted olefins, whose ratios were controlled by the electronic as well as steric effects of the alkyne substrates. In the experimental materials used by the author, we found 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Application In Synthesis of 3-(4-Pyridyl)-2-propyn-1-ol)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-(4-Pyridyl)-2-propyn-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Photochemical synthesis and properties of axially chiral naphthylpyridines》 were Wessig, Pablo; Pick, Charlotte. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2011. Electric Literature of C8H7NO The author mentioned the following in the article:

Five alkynyl pyridines were prepared and cyclized to naphthylpyridines as the main products in the course of a Photo-Dehydro-Diels-Alder reaction. Four of the final products (I,II,III,IV) are axially chiral and the determination of the rotational barrier by DFT calculations, dynamic NMR and HPLC experiments is demonstrated. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Electric Literature of C8H7NO) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C8H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts