Shaghafi, Michael B.; Barrett, David G.; Willard, Francis S.; Overman, Larry E. published an article on February 15 ,2014. The article was titled 《The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 93524-95-9 The information in the text is summarized as follows:
We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, I.HCl, II.HCl and III.HCl, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of IV.HCl, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. In the experimental materials used by the author, we found 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9SDS of cas: 93524-95-9)
3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 93524-95-9
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