Category: 46190-45-8

Reference of 46190-45-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate. A new synthetic method of this compound is introduced below.

Step 3 4-(2-Phenoxy-ethyl)-benzoic Acid Methyl Ester 72 4-(2-Hydroxyethyl)benzoic acid methyl ester 71 (1.622 g, 9.00 mmol), triphenyl phosphine (3.541 g, 13.50 mmol), and diethyl azodicarboxylate (2.13 ml, 13.50 mmol) were dissolved in 50 ml of tetrahydrofuran at room temperature and allowed to stir for 30 minutes. Phenol (0.847 g, 9.00 mmol) was added and the mixture was allowed to stir overnight. The mixture was diluted with water and extracted with diethyl ether. The extracts were dried over anhydrous sodium sulfate and concentrated en vacuo. The residue was purified by flash chromatography on silica eluted with 99:1 hexane/acetone to give 387 mg (16.8%) of 4-(2-phenoxy-ethyl)-benzoic acid methyl ester 72 as a clear oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,46190-45-8, Methyl 4-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; Cournoyer, Richard Leo; Keitz, Paul Francis; Lowrie Jr., Lee Edwin; Muehldorf, Alexander Victor; O’Yang, Counde; Yasuda, Dennis Mitsugu; US2001/56100; (2001); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 46190-45-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2005, as common compound, the synthetic route is as follows.

A solution of 13 (1.16 g, 6.44 mmol) in CH2Cl2 (20 mL) was added DAST (1.56 g, 9.66 mmol) at 0 C. The mixture was warmed to ambient temperature and stirred overnight, then ethyl acetate(100 mL) was added, washed with water (50 mL), saturated Na2CO3 (50 mL), saturated NaCl (50 mL), and dried over Na2SO4.After evaporation of the solvent in vacuo, the crude product was purified by chromatography with hexane-ether (10:1) to afford 1.06 g (91%) of 15 as a colorless oil. TLC Rf 0.25 (hexane-ether10:1); 1H NMR (300 MHz, CDCl3) delta 8.01 (d, J = 8.4 Hz, 2H), 7.33(d, J = 8.1 Hz, 2H), 4.67 (dt, J = 47.1 Hz, J = 6.3 Hz, 2H), 3.93 (s,3H), 3.08 (dt, J = 24.6 Hz, J = 6.3 Hz, 2H).

The chemical industry reduces the impact on the environment during synthesis 46190-45-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 2988 – 2998;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts