Category: 621-63-6

Synthetic Route of 621-63-6, Adding some certain compound to certain chemical reactions, such as: 621-63-6, name is 2,2-Diethoxyethanol,molecular formula is C6H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-63-6.

(b) 2,2-Diethoxyethyl (S)-(+)-Camphorsulfonate 2,2-Diethoxyethanol (3.82 g), Et3N (3.17 g), dichloromethane (40 mL) and DMAP (4 mg) are combined and the solution is cooled to 4° C. (S)-Camphorsulfonyl chloride (7.5 g) is added at a rate of 1 g /min. The ice-water bath is removed and the reaction is allowed to progress for about 1 hour at room temperature. About 40 mL of water is added slowly to quench the reaction, the phases are separated and the dichloromethane phase is washed with saturated sodium bicarbonate (20 mL) and water (20 mL). The solution is vacuum concentrated to produce 7.9 g of 2,2-diethoxyethyl (S)-(+)-camphorsulfonate.

According to the analysis of related databases, 621-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Brantford Chemicals Inc.; US6380388; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

621-63-6 , The common heterocyclic compound, 621-63-6, name is 2,2-Diethoxyethanol, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(d) 2,2-Diethoxyethyl (2S)-2-(Acetyloxy)phenylacetate A 3-necked, 250 mL, round bottom flask equipped with a stir bar and a condenser is charged with 2,2-diethoxyethanol (10 g), dry methylene chloride (100 mL) and triethylamine (9 g). The mixture is cooled to 0-5¡ã C. over a period of 1-2 hours. The flask is slowly charged with (2S)-2-(acetyloxy)phenylacetyl chloride (16.6 g) while maintaining IT<10¡ã C. over a period of 0.5-1 hour. The reaction is stirred at 15-20¡ã C. for 1-2 hours. The reaction mixture is filtered and the filter cake is washed with dichloromethane (10 mL). The organic layer is transferred to a separatory funnel and washed with deionized water (2*40 mL) followed by brine (1*30 mL). The organic layer is dried over anhydrous sodium sulfate and evaporated to give 21 g of 2,2-diethoxyethyl (2S)-2-(acetyloxy)phenylacetate as a syrup. According to the analysis of related databases, 621-63-6, the application of this compound in the production field has become more and more popular. Reference:
Patent; Brantford Chemicals Inc.; US6380388; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts