Category: 6850-39-1

Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia published the artcile< Modular click chemistry libraries for functional screens using a diazotizing reagent>, SDS of cas: 6850-39-1, the main research area is alkyl aryl azide triazole chemoselective preparation; fluorosulfonyl azide generation chemoselective diazotization primary amine; combinatorial generation library alkyl aryl azide cycloaddition alkyne; functional screen click chem azide generated in situ.

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles.

Nature (London, United Kingdom) published new progress about Alkyl azides Role: CMB (Combinatorial Study), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Clive, Derrick L. J.; Peng, Jianbiao; Fletcher, Stephen P.; Ziffle, Vincent E.; Wingert, David published the artcile< Synthesis of Diverse 2,3-Dihydroindoles, 1,2,3,4-Tetrahydroquinolines, and Benzo-Fused Azepines by Formal Radical Cyclization onto Aromatic Rings>, HPLC of Formula: 6850-39-1, the main research area is dihydroindole preparation; quinoline benzotetrahydro stereoselective preparation; tetrahydrobenzoazepine preparation; iodophenol chiral amino alc coupling; aryl amino alc stereoselective preparation N protection; hydroxyalkylhydroxyphenyl carbamate stereoselective preparation iodination; hydroxyphenyliodoalkyl carbamate stereoselective preparation oxidation; iodoalkylcyclohexadienyl carbamate stereoselective preparation radical cyclization; hexahydroindole carbamate preparation rearomatization; hexahydroquinoline carbamate stereoselective preparation rearomatization; carbamate hexahydroindole stereoselective preparation Grignard.

2,3-Dihydroindoles, 1,2,3,4-tetrahydroquinolines, e.g., I, and 2,3,4,5-tetrahydrobenzo[b]azepines are available by a process that represents formal radical cyclization onto aromatic rings. Optically pure benzo-fused heterocycles are also accessible by this method. P-Iodophenols, especially those with the phenolic oxygen protected as a MOM-ether, can be coupled with amino alcs. to produce N-aryl amino alcs., which can be converted into the corresponding alkyl iodides in which the nitrogen is protected as a carbamate. These compounds give cross-conjugated ketones after removal of the phenolic protecting group and oxidation with PhI(OAc)2 in the presence of MeOH. The ketones undergo 5-, 6- or 7-exo-trigonal radical cyclization, and then exposure to acid, or sequential treatment with a Grignard reagent and then acid, effects rearomatization to produce the benzo-fused nitrogen heterocycles.

Journal of Organic Chemistry published new progress about Aromatization. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, HPLC of Formula: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Greenhill, John V.; Ramli, Mohamed; Tomassini, Therezinha published the artcile< Reduction of enaminones in the preparation of 3-aminocyclohexanols. Novel preparation of tetronic acid>, Formula: C6H13NO, the main research area is aminocyclohexanol; cyclohexanol amino; reduction enaminone; tetronate.

Reduction of enaminones by Raney Ni gave the corresponding 3-aminocyclohexanols, of which the major product was trans when the substrate was N-unsubstituted. Thus 3-aminocyclohex-2-enone gave 75% of a 59:31 mixture of trans- and cis-3-aminocyclohexanol. The position of attack of NH3 on 2-acetylcyclopentanone and -hexanone was elucidated by reduction of the derived enaminones. The base attacked the side-chain CO in the former case but in the latter the ring CO was attacked. Reduction of 2-(substituted amino)fumaric esters gave enaminone analogs of tetronic acid (I), which on hydrolysis gave I.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Formula: C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernath, G.; Lang, K. L.; Gondos, Gy.; Marai, P.; Kovacs, K. published the artcile< Stereochemical studies on 1,3-difunctional cyclopentane, cyclohexane, and cycloheptane derivatives>, Application of C6H13NO, the main research area is review stereochem functional cycloalkane.

A review of cyclic 1,3-amino alcs. with 92 references Stereospecific syntheses, kinetic studies, N → O acyl migrations were summarized.

Acta Physica et Chemica published new progress about Amines Role: PRP (Properties). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Application of C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O. published the artcile< One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles>, Computed Properties of 6850-39-1, the main research area is one pot parallel combinatorial synthesis dialkylaminotetrazole; aminotetrazole library preparation; 2,2,2-trifluoroethylthiocarbamate; REAL (readily accessible) compounds; heterocyclization; tetrazoles; thiourea.

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

ACS Combinatorial Science published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Computed Properties of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger published the artcile< Resolution of trans-3-aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is Resolution separation enzymic amino cyclohexanol preparation; crystal structure hydroxycyclohexylimino thiadiazolyl benzamide preparation; mol structure hydroxycyclohexylimino thiadiazolyl benzamide preparation.

(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess. The reaction of 5-(4-cyanophenyl)-3-methyl-2-(methylthio)-1,3,4-thiadiazolium perchlorate with (-)-(1R,3R)-3-aminocyclohexanol thus prepared gave 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzonitrile (I). The crystal and mol. structures of 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzamide were reported.

Tetrahedron: Asymmetry published new progress about Crystal structure. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jia; Chen, Xiaoyan; Hu, Youhong; Cheng, Gang; Zhong, Dafang published the artcile< Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics>, Formula: C6H13NO, the main research area is bromhexine metabolite blood analysis liquid chromatog mass spectrometry pharmacokinetics.

(E)-4-hydroxydemethylbromhexine (E-4-HDMB) and (E)-3-hydroxydemethylbromhexine (E-3-HDMB) were found as major metabolites, while (Z)-4-hydroxydemethylbromhexine and (Z)-3-hydroxydemethylbromhexine as minor metabolites of bromhexine in human plasma. These compounds were identified in comparison with synthetic authentic samples. A sensitive and selective rapid resolution liquid chromatog. tandem mass spectrometry (RRLC-MS/MS) method was developed to quantify the concentration of bromhexine and its two major metabolites (E-4-HDMB and E-3-HDMB) in human plasma. Following solid phase extraction, the analytes were separated on a Zorbax 1.8 μm particle size reversed-phase C18 column, using a gradient elution program with solvents consisting of 0.1% formic acid in acetonitrile and 0.1% formic acid in 5 mM ammonium acetate at a flow rate of 0.7 mL/min. Detection was carried out with an Agilent 6460 triple-quadrupole mass spectrometer operated with an electrospray ionization source mode operated in the pos. ion mode. The recovery of bromhexine, E-4-HDMB, E-3-HDMB, and internal standard (IS) was 63.1-70.9%, 60.5-68.4%, 57.0-63.5%, and 87.8%, resp. The matrix factors of bromhexine, E-4-HDMB, E-3-HDMB, and IS were 89.9-96.7%, 89.6-94.8%, 90.4-91.4%, and 103%, resp. After an oral administration of 8.0 mg bromhexine to five healthy male subjects, AUC0-24 h values of bromhexine, E-4-HDMB, and E-3-HDMB were found to be 93.5 ± 31.9, 34.0 ± 14.5, and 15.8 ± 6.89 ng h/mL, resp.; while C max values were 24.6 ± 5.16, 3.11 ± 1.13, and 5.36 ± 2.55 ng/mL, resp. Plasma concentration of bromhexine, E-4-HDMB, and E-3-HDMB declined with t 1/2 which gave 3.6 ± 0.5, 8.4 ± 2.7, and 6.4 ± 2.5 h, resp.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Blood analysis. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Formula: C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anandan, Sampath-Kumar; Webb, Heather K.; Do, Zung N.; Gless, Richard D. published the artcile< Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble epoxide hydrolase>, Recommanded Product: 3-Aminocyclohexanol, the main research area is unsym aryl urea derivative preparation soluble epoxide hydrolase inhibitor; aryl amide derivative preparation soluble epoxide hydrolase inhibitor.

Incorporation of an adamantyl group in prototypical soluble epoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. Replacement of the adamantyl group in unsym. ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors, e.g., I and II, is explored. Aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded enzyme IC50 values comparable to the adamantyl compounds in an ether substituted, unsym. N,N’-diaryl urea or amide scaffold.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guan, Ruqun; Jing, Lingyan; Zhang, Xiaoming; Chen, Shuai; Xue, Nan; Yang, Hengquan published the artcile< Microspherical nitrogen-doped carbon nanotube assembly derived from Pickering droplets>, SDS of cas: 6850-39-1, the main research area is microspherical nitrogen carbon nanotube Pickering droplet.

Carbon nanotube assemblies with controlled morphol. and tailored architecture offer great potentials for myriad applications, but strategies for their production have remained a significant challenge. Here, we proposed a novel and simple microconfined-annealing strategy, in which a Pickering microdroplet patterned method and unique pyrolysis-stimulated-transformation processes were coupled unprecedentedly, for the fabrication of spherical nitrogen-doped carbon nanotube assemblies (NCNTA). Based on this strategy, the as-prepared superstructures not only retained the micrometer-size and well-defined morphol. of the initial Pickering droplets, but also derived a hierarchical pomegranate-like structure where numerous interconnected NCNT particles were encapsulated by a carbon crust. More importantly, the interior architectures were shown to be manipulated through controlling synthesized parameters. Owing to the unique structure and composition of these assemblies, the yielded superstructures exhibited excellent performance and good recyclability in heterogeneous catalysis applications. This synthetic strategy provides new routes to access other micro- or macroscopic materials with novel structures and paves the way to expand their potential applications.

Carbon published new progress about Aminoplasts Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Xu; Song, Ning; Saidahmatov, Abdusaid; Wang, Peipei; Wang, Yong; Hu, Xiaobei; Kan, Weijuan; Zhu, Wei; Gao, Lixin; Zeng, Mingjie; Wang, Yujie; Li, Chunpu; Li, Jia; Liu, Hong; Zhou, Yubo; Wang, Jiang published the artcile< Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia>, Recommanded Product: 3-Aminocyclohexanol, the main research area is acute myeloid leukemia CDK9 inhibitors antiproliferative activity bioavailability SAR.

CDK9 is an essential drug target correlated to the development of acute myeloid leukemia (AML). Starting from the hit compound 10, which was discovered through a screening of our inhouse compound library, the structural modifications were carried out based on the bioisosterism and scaffold hopping strategies. Consequently, compound 37 (I) displayed the optimal CDK9 inhibitory activity with an IC50 value of 5.41 nM, which was nearly 1500-fold higher than compound 10. In addition, compound 37 exhibited significant antiproliferative activity in broad cancer cell lines. Further investigation of in vivo properties demonstrated that compound 37 could be orally administrated with an acceptable bioavailability (F = 33.7%). In MV-4-11 s.c. xenograft mouse model, compound 37 (7.5 mg/kg) could significantly suppress the tumor progression with a T/C value of 27.80%. Compound 37 represents a promising lead compound for the development of a novel class of CDK9 inhibitors for the treatment of acute myeloid leukemia.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts