Category: 2979-22-8

Application of 2979-22-8 ,Some common heterocyclic compound, 2979-22-8, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the appropriate alcohol (10mmol) in dry CH2Cl2 (20ml) was added Bu2SnO (0.2mmol) followed by the addition of pTsCl e (10mmol) and TEA (10mmol). The reaction mixture was kept under vigorous stirring at rt for 1-6h. The reaction mixture was quenched by adding water. The solution was extracted with dichloromethane and then combined organic phase were washed with a saturated aqueous solution of brine and dried over anhydrous Na2SO4. The solvent removing in vacuo give a residue that was crystallized or chromatographed to afford the desired compounds (1-5).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2979-22-8, its application will become more common.

Reference:
Article in Press; Pasquinucci, Lorella; Turnaturi, Rita; Prezzavento, Orazio; Arena, Emanuela; Arico, Giuseppina; Georgoussi, Zafiroula; Parenti, Rosalba; Cantarella, Giuseppina; Parenti, Carmela; Bioorganic and Medicinal Chemistry; (2017);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2979-22-8, name is 2-Methoxy-2-phenylethanol, molecular formula is C9H12O2, molecular weight is 152.19, as common compound, the synthetic route is as follows.COA of Formula: C9H12O2

General procedure: An aldehyde (30 mmol), Zn(OTf)2 (13 mg, 35 mmol), and (N-Chloroethyl)morpholine HCl 6.5 mg, 35 mmol) were added to a 1dram vial. The dry solvent, acetonitrile (1mL), was added to the vial. Afterwards dipicolylamine (7 muL 35 mmol) was added to the vial and the vial was sonicated. Once the solution was transparent molecular sieves were added to the solution along with the respective alcohol (175 mmol). The assemblies were incubated for 16 h at room temperature in the dark.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2979-22-8, 2-Methoxy-2-phenylethanol, and friends who are interested can also refer to it.

Reference:
Article; Minus, Matthew B.; Featherston, Aaron L.; Choi, Sooyun; King, Sam C.; Miller, Scott J.; Anslyn, Eric V.; Chem; vol. 5; 12; (2019); p. 3196 – 3206;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2979-22-8 , The common heterocyclic compound, 2979-22-8, name is 2-Methoxy-2-phenylethanol, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An aldehyde (30 mmol), Zn(OTf)2 (13 mg, 35 mmol), and (N-Chloroethyl)morpholine HCl 6.5 mg, 35 mmol) were added to a 1dram vial. The dry solvent, acetonitrile (1mL), was added to the vial. Afterwards dipicolylamine (7 muL 35 mmol) was added to the vial and the vial was sonicated. Once the solution was transparent molecular sieves were added to the solution along with the respective alcohol (175 mmol). The assemblies were incubated for 16 h at room temperature in the dark.

The synthetic route of 2979-22-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Minus, Matthew B.; Featherston, Aaron L.; Choi, Sooyun; King, Sam C.; Miller, Scott J.; Anslyn, Eric V.; Chem; vol. 5; 12; (2019); p. 3196 – 3206;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts