Category: 63478-76-2

Adding a certain compound to certain chemical reactions, such as: 63478-76-2, 6-Heptyn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H12O, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H12O

Part A: Synthesis of tert-butyl(hep iIane To a stirred solution of hept-6-yn-l-ol (5.3 g, 47.25 mmol) in dry THF (450 ml) was added imidazole (7.08 g, 103.95 mmol) followed by tert-butyldimethylsilylchloride (7.83 g, 51.97 mmol) under nitrogen. The mixture was stirred for 16 h at room temperature before water (200 ml) and hexane (250 ml) were added. The layers were separated and the aqueous phase was extracted with hexane. The combined organic phases were dried over MgSO4, filtered and concentrated to give the protected alcohol. The crude product was purified by column chromatography (SiO2, 0 – 1.5% ethyl acetate in petroleum spirit) to give the pure tert-butyl(hept-6-ynyloxy)dimethylsilane as a colourless oil (8.23 g, 77%). The product was used immediately in the next reaction step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63478-76-2, 6-Heptyn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2009/111830; (2009); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 63478-76-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6-heptynol (331 mg, 2.95 mmol) in 10 ml of methanol was added KOH in 5 ml of H2O. After 10 min, iodine (824 mg, 3.24 mmol) was added at 0 C. and warmed to rt and stirred for 2 hr. The reaction was then quenched with water and extracted with ether (20 ml three times). The solvent was removed in vacuo, the residue dissolved in CH2Cl2, washed with brine and dried over MgSO4. Purification by silica gel chromatography (hexane:ethyl acetate=4:1) gave the product 498 mg (71% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63478-76-2, 6-Heptyn-1-ol.

Reference:
Patent; Iowa State University Research Foundation, Inc.; US2005/272954; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63478-76-2, name is 6-Heptyn-1-ol. A new synthetic method of this compound is introduced below., Quality Control of 6-Heptyn-1-ol

Following a reported procedure,9 hept-6-yn-1-ol (50) (5.00 g, 44.6 mmol, 1.00 equiv.) was dissolved intetrahydrofuran (150 mL) and the solution was cooled down at – 78 C. A cooled 2.5 M solution of nbutyllithiumin hexanes (nBuLi, 39.2 mL, 98.0 mmol, 2.20 equiv.) was added dropwise, followed by 4-(dimethylamino)pyridine (DMAP, 1.36 g, 11.1 mmol, 0.25 equiv.). After stirring for 1 hour at thistemperature, trimethylsilyl chloride (TMS-Cl, 20.4 mL, 156 mmol, 3.50 equiv.) was added dropwise. Themixture was then allowed to warm to room temperature. After 2 hours of stirring, the reaction wasquenched with a 1.0 N aqueous hydrochloric acid (50 mL) and vigorously stirred at room temperatureover 30 minutes. The mixture was then diluted with ethyl acetate (200 mL) and the layers wereseparated. The aqueous phase was extracted with additional portions of ethyl acetate (3 x 50 mL). Thecombined organic layers were collected, washed with a solution of saturated aqueous sodiumbicarbonate (100 mL), brine (50 mL), dried over magnesium sulfate, filtered and concentrated in vacuo.After purification by column chromatography (SiO2, Pentane:Ethyl acetate 4:1), 7-(trimethylsilyl)hept-6-yn-1-ol (51) (6.58 g, 35.7 mmol, 80% yield) was obtained as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 63478-76-2, 6-Heptyn-1-ol.

Reference:
Article; Tessier, Romain; Ceballos, Javier; Guidotti, Nora; Simonet-Davin, Raphael; Fierz, Beat; Waser, Jerome; Chem; vol. 5; 8; (2019); p. 2243 – 2263;,
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Application of 63478-76-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 63478-76-2, name is 6-Heptyn-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 6-heptyn-1-ol 812 (3.33 mL, 26.75 mmol) in CH2CI2 (80 mL) at r.t. was added imidazole (1.76 g, 27.01 mmol) and terf-butyldimethylsilyl chloride (4.07 g, 27.01 mmol). The reaction mixture was allowed to stir at r.t. for 24 h. The mixture was then diluted with Et24 and concentrated in vacuo. The crude product was purified by filtration through silica gel to give alkyne 813 (5.68 g, q uant.) as a colourless liquid . Alkyne 813 was used in subsequent synthetic steps without characterisation.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63478-76-2, 6-Heptyn-1-ol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; BRIMBLE, Margaret Anne; WILLIAMS, Geoffrey Martyn; DUNBAR, Peter Roderick; VERDON, Daniel; (184 pag.)WO2017/145097; (2017); A2;,
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Related Products of 63478-76-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, molecular weight is 112.1696, as common compound, the synthetic route is as follows.

Using the methodology in stage (vi) of Process C, hept-6-ynal was prepared from hept-6-yn-1-ol (C. Crisan Chem . Abs . 51 :5061b). The preparation of hept-2-en-6-ynal and 1,1,1-trichloropentan-4-one is described in EP 029 4 229.

Statistics shows that 63478-76-2 is playing an increasingly important role. we look forward to future research findings about 6-Heptyn-1-ol.

Reference:
Patent; THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; EP372816; (1990); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 63478-76-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, molecular weight is 112.1696, as common compound, the synthetic route is as follows.

A solution of Dess-Martin-periodinane (5.09 g, 12.0 mmol, 2.0 equiv) in dry DCM (27 mL) was cooled to 0 C, 6-heptyn-1-ol (673 mg, 6.00 mmol, 1.0 equiv) in DCM (3 mL) was added and the mixture was stirred at 23 C for 5 h. DCM (5 mL) was added, the mixture was washed with sat. aq. Na2S2O3-sol. (30 mL), 1 M NaOH (30 mL), and sat. aq. NaCl (30 mL). The aq. phase was extracted with DCM (90 mL), the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure. The residue was purified on silica gel (n-pentane/Et2O, 9:1) to yield the title compound as a colourless oil (337 mg, 3.06 mmol, 51%).

Statistics shows that 63478-76-2 is playing an increasingly important role. we look forward to future research findings about 6-Heptyn-1-ol.

Reference:
Article; Rode, Katharina; Palomba, Martina; Ortgies, Stefan; Rieger, Rene; Breder, Alexander; Synthesis; vol. 50; 19; (2018); p. 3875 – 3885;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 63478-76-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, molecular weight is 112.1696, as common compound, the synthetic route is as follows.

A solution of Dess-Martin-periodinane (5.09 g, 12.0 mmol, 2.0 equiv) in dry DCM (27 mL) was cooled to 0 C, 6-heptyn-1-ol (673 mg, 6.00 mmol, 1.0 equiv) in DCM (3 mL) was added and the mixture was stirred at 23 C for 5 h. DCM (5 mL) was added, the mixture was washed with sat. aq. Na2S2O3-sol. (30 mL), 1 M NaOH (30 mL), and sat. aq. NaCl (30 mL). The aq. phase was extracted with DCM (90 mL), the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure. The residue was purified on silica gel (n-pentane/Et2O, 9:1) to yield the title compound as a colourless oil (337 mg, 3.06 mmol, 51%).

Statistics shows that 63478-76-2 is playing an increasingly important role. we look forward to future research findings about 6-Heptyn-1-ol.

Reference:
Article; Rode, Katharina; Palomba, Martina; Ortgies, Stefan; Rieger, Rene; Breder, Alexander; Synthesis; vol. 50; 19; (2018); p. 3875 – 3885;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts