Category: 5339-85-5

Electric Literature of 5339-85-5 , The common heterocyclic compound, 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(Aminophenyl)ethanol(11, 2.4 g, 20 mmol, 1.0 equiv) was dissolved in CH2Cl2(40 mL, abs.) and cooled to 0 C. Pyridiniumchlorochromate(PCC, 13, 6.5 g, 30 mmol, 1.5 equiv) was added in small portions.The mixture was kept at 0 C for 1 h and then stirred for 4 h at room temperature. Silica was added to the mixture and the solvent was evaporated. Purification was performed by distillation. Yield 71.9%. 1H NMR (500 MHz, DMSO) d 6.60(s, 2H), 6.66 (d, J = 8.1 Hz, 1H), 6.73-6.77 (m, 1H), 7.27-7.32(m, 1H), 7.45 (d, J = 8.2, 1H), 9.89 (s, 1H). 13C NMR (126 MHz,DMSO) d 115.5, 116.2, 118.4, 134.9, 135.5, 149.3, 193.1.C7H7NO. MS (ESI+): m/z 122.6 (4.5, (M+H)+), 144.6 (100,(M+Na)+). (agrees with28)

The synthetic route of 5339-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Merk, Daniel; Gabler, Matthias; Gomez, Roberto Carrasco; Flesch, Daniel; Hanke, Thomas; Kaiser, Astrid; Lamers, Christina; Werz, Oliver; Schneider, Gisbert; Schubert-Zsilavecz, Manfred; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2447 – 2460;,
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Reference of 5339-85-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.

General procedure: To an oven-dried, nitrogen purged Schlenk tube containing [Ru(p-cymene)Cl2]2(46.9 mg, 0.075 mmol), dppb (64.0 mg, 0.15 mmol) and Cs2CO3(97.7 mg, 0.30 mmol) was added alcohol (3 mmol), amine (0.33 mmol),3-methyl-2-butanone (0.8 ml, 7.5 mmol) and tBuOH(3 ml) and the reaction heated at reflux for 24 h. On completion, the reaction was allowed to cool to room temperature before the solvent was removed invacuo. The crude product was purified by column chromatography (diethyl ether/petroleum ether (b.p. 40-60 C) as eluent) before recyrstallization from(dichloromethane/hexane), to afford the corresponding amide in good yield.

The chemical industry reduces the impact on the environment during synthesis 5339-85-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Watson, Andrew J.A.; Wakeham, Russell J.; Maxwell, Aoife C.; Williams, Jonathan M.J.; Tetrahedron; vol. 70; 23; (2014); p. 3683 – 3690;,
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Application of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a 25 mL Schlenk tube, ketones (1 mmol) and 2-aminobenzylalcohol (1.1 mmol) (for quinolines), or 2-(2-aminophenyl)ethanol(1 mmol) (for indole), [Cp*IrCl2]2 (1 mol %, 0.01 mmol, 7.96 mg), 4a(2 mol %, 0.02 mmol, 7.60 mg), KOH (10 mol %, 0.1 mmol, 5.6 mg),and toluene (5 mL) were placed under N2. The reaction mixturewasheated under reflux for 24 h. The reaction mixture was cooled toambient temperature, concentrated in vacuo, and purified by flashcolumn chromatography with petroleum ether/ethyl acetate toafford the corresponding quinolines and indole.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Article; Huang, Shuang; Wu, Si-Peng; Zhou, Quan; Cui, He-Zhen; Hong, Xi; Lin, Yue-Jian; Hou, Xiu-Feng; Journal of Organometallic Chemistry; vol. 868; (2018); p. 14 – 23;,
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Electric Literature of 5339-85-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5339-85-5 as follows.

The conversion of 2-(o-aminophenyl)ethanol and the yield of indole were 100% and 91.6%, respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5339-85-5, its application will become more common.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
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Synthetic Route of 5339-85-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5339-85-5 as follows.

COMPARATIVE EXAMPLE 8 The procedures of Example 13 were repeated except that 0.1 g of “CDT-60” was used without K2 CO3. The conversion of 2-(o-aminophenyl)ethanol was 28.6% and the yield of indole was 24.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5339-85-5, its application will become more common.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
Alcohol – Wikipedia,
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Synthetic Route of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of Fmoc-Leu-OH, 2- (4-aminophenyl) ethanol, and EEDQ in 1: 1 toluene : ethanol is stirred at room temperature under nitrogen for 3 days. Additional 2- (4-AMINOPHENYL) ethanol, and EEDQ are added if the reaction is incomplete, and the reaction is stirred for another 24 hours. The solution is concentrated under reduced pressure, and the resulting residue is taken up in dichloromethane, and washed consecutively with 0.1 N HCI, saturated NAHG03, and saturated NACL. The organic solution is dried (MgS04) and concentrated, and the residue is purified by silica flash chromatography using a hexane: ethyl acetate mobile phase to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/23314; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

From the reaction solution, 0.24 g of the catalyst was recovered. The recovered catalyst was regenerated by supporting 12 mg (5wt%) of K2 CO3. The procedures of Example 1 was repeated except that the so regenerated catalyst was used. The conversion of 2-(o-aminophenyl)ethanol was 100% and the yield of indole was 87.7%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(2-Aminophenyl)ethanol

Under protection of nitrogen, 2-aminophenylethanol (1.30 g, 9.5 mmol) was dissolved in anhydrous tetrahydrofuran (100 mL), the resulting solution was slowly added dropwise to a suspension of sodium hydride (60%, 0.42 g, 10.4 mmol) in anhydrous tetrahydrofuran (20 mL), the mixture was stirred for 15 min at room temperature, and added with tert-butyldiphenylchlorosilane (2.86 g, 10.4 mmol), and stirred for 20 hrs at room temperature. The reaction system was added with water, and extracted with methyl tert-butyl ester. The extracts were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure, to obtain a brown oil (3.75 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD; Cheng, Jianjun; Qin, Jihong; Ye, Bin; US2014/206679; (2014); A1;,
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Reference of 5339-85-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: A test tube (25 mL) wascharged with 2-aminophenethyl alcohol 1? (0.5 mmol, 1 equiv), aldehyde 2?? (0.75mmol, 1.5 equiv), AgOTf (0.025 mmol, 5 mol%), HOTf (0.05 mmol, 10 mol%), and toluene (3 mL) were added. Themixture was stirred at 120 oC in air for 12 hours, thereaction was cooled down to room temperature, the mixture was quenched by sat.aq. NaHCO3, and diluted with 10 mL dichloromethane and washed with10 mL H2O. The aqueous layer was extracted twice withdichloromethane (10 mL) and the combined organic phase was dried over Na2SO4.After evaporation of the solvents, the residue was purified by silica gelchromatography (hexane/AcOEt = 30:1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5339-85-5, 2-(2-Aminophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Xu, Xuefeng; Zhang, Xu; Liu, Wenming; Zhao, Qiang; Wang, Zhiqiang; Yu, Lintao; Shi, Fu; Tetrahedron Letters; vol. 56; 24; (2015); p. 3790 – 3792;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(2-Aminophenyl)ethanol

COMPARATIVE EXAMPLE 7 The first run procedures of Example 12 were repeated except that 0.15 g of “NDT-90” was used without K2 CO3 and reaction was continued for 9 hours. The conversion of 2-(o-aminophenyl)ethanol was 12.5% and the yield of indole was 10.8%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts