Category: 5344-90-1

Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols>, Application of C7H9NO, the main research area is ketone preparation; primary alc secondary cross coupling cobalt catalyst; aryl quinoline preparation; amino alc secondary cross coupling cobalt catalyst.

Cobalt(II) complexes (5 mol% Co) bearing phosphine-free N N N pincer ligands efficiently catalyze C-C coupling of secondary and primary alcs. to selectively form α-alkylated ketones with a good functional group compatibility using NaOH (20 mol%) as a base at 120 °C. The NH group on the N N N-Co(II) precatalyst controlled the activity and selectivity. This simple catalytic system was also involved in the synthesis of 2-aryl quinolines, e.g., I, via the dehydrogenative annulation of 2-aminobenzyl alcs. with secondary alcs.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nallagangula, Madhu; Sujatha, Chandragiri; Bhat, Venugopal T.; Namitharan, Kayambu published the artcile< A nanoscale iron catalyst for heterogeneous direct N- and C-alkylations of anilines and ketones using alcohols under hydrogen autotransfer conditions>, Synthetic Route of 5344-90-1, the main research area is aryl amine preparation; alc amine alkylation iron catalyst; preparation aryl ketone; acetophenone alc alkylation iron catalyst; quinoline preparation; amino benzyl alc Friedlander iron catalyst.

An efficient synthesis of amine and ketone derivatives RCH2NHR1 [R = n-pentyl, Ph, 4-OMe, etc.; R1 = Ph, 2-MeOC6H4, 2-pyridyl etc.] and R2CH2CH2C(O)R3 [R2 = Ph, 2-MeC6H4, 4-MeSC6H4, etc.; R3 = Ph, 4-MeC6H4, 4-EtOC6H4, etc.] was described via heterogeneous iron catalyzed direct N- and C-alkylation reactions of amines and acetophenones with alcs. under hydrogen autotransfer conditions. In addition, modified Friedlander synthesis of quinolines I [R4 = H, Me; R5 = Ph, 4-EtC6H4, 4-FC6H4, etc.] was demonstrated from 2-amino benzyl alcs. and acetophenones. A hydrogen autotransfer mechanism was found to operate in these reactions by deuterium labeling studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiangchao; Ai, Yao; Wang, Rongzhou; Liu, Liping; Yang, Jiazhi; Li, Feng published the artcile< Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is quinoline preparation green chem; aminobenzyl alc ketone acceptorless dehydrogenative coupling ruthenium catalyst.

A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines I [R = H, Cl, Br; R1 = H, F, Cl, Me, OMe; R2 = t-Bu, cyclopropyl, Ph, pyrazin-2-yl, etc.; R3 = H, Me, Et] and 5,6-dihydrobenzo[c]acridine via acceptorless dehydrogenative coupling of o-aminobenzyl alcs. 2-NH2-4-R-5-R1-C6H2CH2OH with ketones R2C(O)CH2R3 and 1-tetralone in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biol. active mol. was also undertaken. Notably, this research exhibits new potential of metal-ligand bifunctional catalysts for acceptorless dehydrogenative reactions.

Journal of Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kavitha, B.; Sravanthi, M.; Saritha Reddy, P. published the artcile< DNA interaction, docking, molecular modelling and biological studies of o-Vanillin derived Schiff base metal complexes>, Related Products of 5344-90-1, the main research area is copper cobalt chromium zinc vanillin Schiff base complex preparation; transition metal Schiff base DNA binding ESR cytotoxic antimicrobial.

In the present studies, [Cu(ABOVL)] 1, [Co(ABOVL)] 2, [Cr(ABOVL)] 3, and [Zn(ABOVL)] 4 complexes were prepared where ABOVL is the condensation product of 2-hydroxy-3-methoxybenzaldehyde (o-Vanillin) and (2-aminophenyl)methanol (2-aminobenzylalc.). To characterize ABOVL and its metal complexes standard anal. and spectral techniques were employed. From the spectral data, ABOVL acts as a bi-dentate ligand with O, N as donor atoms and complex 1 exhibited square planar geometry and complexes 2, 3, and 4 exhibited octahedral geometries resp. DNA binding studies were performed using fluorescence, viscosity and absorption studies. The binding constant from absorption studies was 6.23 ± 0.04 × 104 M-1, 5.76 ± 0.03 × 104 M-1, 4.95 ± 0.07 × 104 M-1 and 4.12 ± 0.06 × 104 M-1 for 1, 2, 3 and 4 complexes resp., and Stern-Volmer quenching constant, KSV from fluorescence studies was 3.99 × 103 M-1, 3.21 × 103 M-1, 2.78 × 103 M-1 and 2.53 × 103 M-1 for 1, 2, 3 and 4 complexes resp. The above data signifies intercalative mode of binding of complexes to CT-DNA. Viscosity studies further revealed the binding of complexes to CT-DNA through intercalation. Nuclease studies of the complexes were carried out using supercoiled pUC19 DNA with hydrogen peroxide as an oxidant and the results were discussed. GOLO 3.1 program (software) was used for docking studies and the results showed that complexes can effective bind with active receptor protein of DNA topoisomerase I involving hydrogen bonding interactions and the results were discussed. Antimicrobial studies performed by disk diffusion method showed that the complexes possess higher anti-microbial activity than compared to ABOVL. In-vitro cytotoxic studies were performed for the synthesized complexes against selected cell lines by MTT assay where Complex 1 showed potential inhibitory efficiency with an IC50 of 49.13 μg/mL as compared to other complexes. Mol. modeling studies were carried out using Argus laboratory

Journal of Molecular Structure published new progress about Antibacterial agents. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Akanksha M.; Digrawal, Naveen Kumar; Mohanta, Nirmala; Jamdade, Akash Bandu; Chaudhari, Moreshwar B.; Bisht, Girish Singh; Gnanaprakasam, Boopathy published the artcile< Catalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditions>, Quality Control of 5344-90-1, the main research area is dicarbonyl amino alc domino enamine ruthenium oxidative cyclization green; tetrahydroindole preparation; tetrahydroacridinone preparation; hydroxybenzyl alc dicarbonyl ruthenium alkylation cyclization dehydrogenation condensation hydrogenation; tetrahydroxanthenone preparation.

A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N-heterocycles by using 1,3-dicarbonyls and amino alcs. through a domino sequential enamine formation and intramol. oxidative cyclization strategy. This unified approach is also applicable for the synthesis of O-heterocycles involving 2-hydroxybenzyl alc. as a coupling reactant via consecutive C-alkylation and intramol. cyclization steps. The present protocol is general for the synthesis of varieties of biol. important scaffolds, such as tetrahydro-4H-indol-4-one, 3,4-dihydroacridin-1(2H)-one, and tetrahydro-1H-xanthen-1-ones derivatives using a single catalytic system, viz. RuH2CO(PPh3)3. Environmentally benign H2O and H2 are the only byproducts in this domino process. Moreover, RuH2CO(PPh3)3-catalyzed C3-alkylation of tetrahydro-4H-indol-4-one using alc. as a alkylating partner is also described in this report. For the first time, a solvent-free gram-scale reaction for the acceptorless dehydrogenative annulation has been demonstrated. A plausible mechanism for the Ru-catalyzed base-free and acceptorless dehydrogenative annulation of amino alcs. or 2-hydroxybenzyl alcs. has been provided with several exptl. investigations and spectroscopic evidence.

Journal of Organic Chemistry published new progress about Acridines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (tetrahydroacridinone). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shui, Hongling; Zhong, Yuhong; Ouyang, Lu; Luo, Nianhua; Luo, Renshi published the artcile< Iridium-Catalyzed Acceptorless Dehydrogenative Coupling of 2-Aminoarylmethanols with Amides or Nitriles to Synthesize Quinazolines>, Application In Synthesis of 5344-90-1, the main research area is quinazoline preparation; aminoarylmethanol amide nitrile acceptorless dehydrogenative coupling iridium catalyst.

An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction for the preparation of various quinazolines from 2-aminoarylmethanols and amides or nitriles had been developed. A wide range of substituted 2-aminobenzyl alcs. and (hetero)aryl or alkyl benzamides and nitriles were well compatible to afford various quinazolines in excellent yields. Merits of this new strategy are the high atom-economy, mild reaction conditions, and simple operation, and the methodol. is suitable for a variety of substrates.

Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nelson, Hope; Richard, William; Brown, Hailee; Medlin, Abigail; Light, Christina; Heller, Stephen T. published the artcile< Practical Chemoselective Acylation: Organocatalytic Chemodivergent Esterification and Amidation of Amino Alcohols with N-Carbonylimidazoles>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is alc carbonylimidazole diazabicycloundecene catalyst chemoselective esterification; carboxylic ester preparation; carbonylimidazole aniline pyridinium chloride catalyst chemoselective amidation; aryl amide preparation; amidation; carbonylimidazoles; chemoselectivity; esterification; organocatalysis.

Here, the N-carbonylimidazoles enable catalytic chemodivergent aniline or alc. acylation in the presence of pyridinium ions or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was reported. Both acylation reactions display high and broad chemoselectivity for the target group. Unprecedented levels of chemoselectivity were observed in the DBU-catalyzed esterification: A single esterification product was obtained from a mol. containing primary aniline, alc., phenol, secondary amide, and N-H indole groups. These acylation reactions are highly practical as they involve only readily available, inexpensive, and relatively safe reagents; can be performed on a multigram scale; and can be used on carboxylic acids directly by in situ formation of the acylimidazole electrophile.

Angewandte Chemie, International Edition published new progress about Acylation (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Wenzhong; Wan, Baibai; Shi, Ran; Chen, Si; Li, Jiazhu; Wang, Fangzhen; Niu, Hexu; Xu, Xin-Ming; Wang, Wei-Li published the artcile< Catalyst-free one-pot cascade cyclization: An efficient synthesis of isoindolobenzoxazinones and isoindoloquinazolinones derivatives>, Category: alcohols-buliding-blocks, the main research area is isoindolobenzoxazinone isoindoloquinazolinone preparation one pot catalyst free; acylbenzoic acid amino alc diamine cascade cyclization.

A practical and efficient catalyst-free cascade cyclization reaction of 2-acylbenzoic acids with various amino alcs. or diamines was developed. This protocol provides a powerful and straightforward method for the one-pot synthesis of diverse isoindolobenzoxazinones, isoindoloquinazolinones and their derivatives The synthetic strategy evades the use of catalyst, shows a broad substrate scope and could be performed in gram-scale.

Tetrahedron published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Monsen, Paige J.; Luzzio, Frederick A. published the artcile< Applicability of aluminum amalgam to the reduction of arylnitro groups>, COA of Formula: C7H9NO, the main research area is aryl amine preparation; arylnitro compound reduction; Aluminum amalgam; Arylnitro groups; Azides; Click chemistry; Reduction.

An array of arylnitro compounds RNO2 [R = 4-methylphenyl, naphthalen-1-yl, (morpholin-4-yl)carbonyl, etc.] with various functionality was treated with freshly-prepared aluminum amalgam in THF/water solution and resulted in the corresponding arylamines RNH2. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20-30 min. The workup of the reductions involves only removal of the insoluble byproducts by filtration followed by concentration Only in some cases is chromatog. required to secure the pure product. The desired arylamines are furnished in quantities of 25-100 mg, which in some cases, could be taken on to the next reaction without further purification Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides, e.g., I were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chem., selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles, e.g., II.

Tetrahedron Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sivakumar, Ganesan; Subaramanian, Murugan; Balaraman, Ekambaram published the artcile< Single-Molecular Mn(I)-Complex-Catalyzed Tandem DoubleDehydrogenative Cross-Coupling of (Amino)Alcohols under Solventless Conditions with the Liberation of H2 and H2O>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is quinoline pyridine preparation green; primary amino alc double dehydrogenative cross coupling manganese.

Sustainable chem. production requires fundamentally new types of catalysts and catalytic technologies. The development of coherent and robust catalytic systems based on earth-abundant transition metals is essential but extremely challenging. Herein, authors report the first report on a single Mn(I)-PNP catalyzed tandem C-C and C-N bond formation via double dehydrogenative coupling of amino alcs. with primary alcs. The current method covers a wide range of substrates, including aryl, aliphatic acyclic, and cyclic primary alcs., as well as amino alcs., to provide diverse N-heterocyclic compounds (pyridine and quinoline derivatives) in good to excellent yields (50 examples). The reaction proceeds under benign, solventless conditions with the liberation of mol. hydrogen and water as the only byproducts. Various control and labeling experiments and kinetic, NMR, and mechanistic studies suggest that the reaction operates via the acceptorless double dehydrogenative coupling pathway, selectively assimilating to provide desired N-heterocycles. Several selective bond activation/formation reactions occur sequentially via amine-amide metal-ligand cooperation.

ACS Sustainable Chemistry & Engineering published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts