Monsen, Paige J.; Luzzio, Frederick A. published the artcile< Applicability of aluminum amalgam to the reduction of arylnitro groups>, COA of Formula: C7H9NO, the main research area is aryl amine preparation; arylnitro compound reduction; Aluminum amalgam; Arylnitro groups; Azides; Click chemistry; Reduction.
An array of arylnitro compounds RNO2 [R = 4-methylphenyl, naphthalen-1-yl, (morpholin-4-yl)carbonyl, etc.] with various functionality was treated with freshly-prepared aluminum amalgam in THF/water solution and resulted in the corresponding arylamines RNH2. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20-30 min. The workup of the reductions involves only removal of the insoluble byproducts by filtration followed by concentration Only in some cases is chromatog. required to secure the pure product. The desired arylamines are furnished in quantities of 25-100 mg, which in some cases, could be taken on to the next reaction without further purification Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides, e.g., I were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chem., selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles, e.g., II.
Tetrahedron Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts