Month: May 2021

Reference of 349-75-7, Adding some certain compound to certain chemical reactions, such as: 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-75-7.

Example 10 Piperazine-1-carboxylic acid 3-trifluoromethyl-benzyl ester hydrochloride was prepared from 3-(trifluoromethyl)-benzyl alcohol; MS (ISP): 289.2 MH+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-75-7, (3-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Davidson, James Edward Paul; Dawson, Claire Elizabeth; George, Ashley Roger; Mansell, Howard Langham; Mattei, Patrizio; Mizrahi, Jacques; Nettekoven, Matthias Heinrich; Pratt, Robert Mark; Roever, Stephan; Roffey, Jonathan Richard Anthony; Specklin, Jean-Luc; Stalder, Henri; Wilkinson, Kerry; US2002/143020; (2002); A1;,
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Application of 10029-04-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. This compound has unique chemical properties. The synthetic route is as follows.

Example 5. To a stirring mixture of monoethyl malonate (5.1 g, 38.6 mmol) , ethyl 2-hydroxylmethyl acrylate (5.02 g, 3.86 mmol), PTSA (50 mg) and hydroquinone (50 mg) , was added toluene (50 mL) and the mixture was refluxed at a temperature of 15O0C to azeotropically remove water.[0079] After cooling, the reaction product was washed consecutively with 30% brine and water, and the organic layer was dried over anhydrous sodium sulfate, filtered and the solvent removed by rotary evaporator. The crude reaction product was purified by vacuum distillation (98- 100C/0.1 mbar) and the ester, C was isolated in 80% yield. 1H NMR (60 MHz, CDCl3) : delta 6.36 (s, IH), 5.87 (s, 1 H), 4.89(s, 2 H), 4.05-4.41 (m, 4 H), 3.43 (s, 2 H), 1.19-1.42 (m, 6 H); FT-IR (film) : 2984.7, 2908.6, 1735.3 (br) , 1640.5, 1513,6, 1447.6, 1332.2, 1145.4, 1031.7, 817.2 cm-1; GC/MS(EI) m/z (%) : 245 (2) [M++ H], 226 (2), 199 (20), 153 (20), 129 (70), 115 (100), 101 (40), 85 (45), 43 (65) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Patent; LOCTITE (R & D) LIMITED; WO2009/53484; (2009); A2;,
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Application of 3391-10-4 ,Some common heterocyclic compound, 3391-10-4, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of benzylic alcohol (10 mmol, 100 mol %) in CHCl3 was slowly added SOCl2 (14.5 mL, 200 mmol) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched with ice/H2O and neutralized with saturated NaHCO3 solution. The organic phase was collected and washed with brine three times, dried over Na2SO4 or MgSO4. After filtration and removal of the solvent under reduced pressure, the residue was purified by flash chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3391-10-4, 1-(4-Chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Qingchen; Wang, Xuan; Qian, Qun; Gong, Hegui; Synthesis; vol. 48; 17; (2016); p. 2829 – 2836;,
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Adding a certain compound to certain chemical reactions, such as: 3068-00-6, 1,2,4-Butanetriol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3068-00-6, blongs to alcohols-buliding-blocks compound. Quality Control of 1,2,4-Butanetriol

General procedure: To a solution of CoCl2 (0.6 mmol) in anhyd MeCN (4 mL), the selecteddialkyl acetal (1 mmol), TMSCl (1.1 mmol), and butane-1,2,4-triol (3 mmol) were added, with stirring, at r.t. At the end ofthe reaction, the mixture was extracted with EtOAc and the combinedextracts were washed with 5% NaHCO3. The organic layerwas dried (anhyd Na2SO4) and filtered, and the solvent was evaporatedunder vacuum. The oils obtained were purified by flash chromatographyto give the desired compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3068-00-6, its application will become more common.

Reference:
Article; Battisti, Umberto Maria; Sorbi, Claudia; Franchini, Silvia; Tait, Annalisa; Brasili, Livio; Synthesis; vol. 46; 7; (2014); p. 943 – 946;,
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Adding a certain compound to certain chemical reactions, such as: 229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 229027-89-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 229027-89-8

General procedure: To a solution of compound 7 in DCM was added compound 8 (0.12mmol) and K2CO3 (0.24mmol) The resulting mixture was refluxed at 80C for 3h before it was quenched with 5mL of brine The organic layer was collected and purified by flash column chromatography on a silica column using cyclohexane/acetone (0-50%) to get compound 9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Pan, Ting; Ding, Yanchao; Wu, Liyang; Liang, Liting; He, Xin; Li, Qianwen; Bai, Chuan; Zhang, Hui; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 480 – 501;,
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Electric Literature of 42514-50-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

48.7 mL (668 mmol) thionyl chloride were slowly added dropwise at 0 C. with vigorous stirring to a solution of 53.0 g (514 mmol) 3-amino-3-methyl-butanol in 255 mL methylene chloride/dimethylformamide (50:1). After the addition had ended the reaction mixture was refluxed for 1 h at reflux temperature and then stirred for 16 h at ambient temperature. The solvent was removed and the residue was combined with 50 mL acetonitrile with stirring. The solid was filtered off and dried for 18 h at 45 C. 67.9 g (430 mmol, 84%) 3-chloro-1,1-dimethylpropylamine-hydrochloride were obtained as a colourless solid.

According to the analysis of related databases, 42514-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/245526; (2005); A1;,
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Electric Literature of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.

General procedure: The compounds 12 (A-G) were synthesized using a similar procedure. Monomethyl ester 7 (2.73 g, 10 mmol) was dissolved in 40 ml of CHCl3, and diluted thionyl chloride was added (1.1 ml, 15 mmol). The mixture was stirred at rt for 8 h. The volatile components were evaporated under reduced pressure, and the residue was dissolved in 20 ml of benzene and evaporated again. The residue was re-dissolved in 40 ml of CHCl3, and the resulting solution was added dropwise to the mixture of D-benzyl 2-hydroxy acetate 11(A-G) (10 mmol) and triethylamine (3.5 ml, 25 mmol) in 20 ml of CHCl3 at C. The solution was stirred at rt for 3 days (monitored with TLC: Petroleum ether/ethyl acetate, 2:1) and then washed successively with 1M NaOH, water, 5% HCl, water, 10% NaHCO3, and brine (25 ml of each). The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to offer crude products, which were was purified by flash column chromatography eluted with petroleum ether/ethyl acetate solution to afford the compounds 12 (A-G) as colorless or light yellow viscous liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Article; Jia, Chao; Yang, Ke-Wu; Liu, Cheng-Cheng; Feng, Lei; Xiao, Jian-Min; Zhou, Li-Sheng; Zhang, Yi-Lin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 482 – 484;,
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Related Products of 627-18-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

At room temperature,In a 500 mL round bottom flask was added dichloromethane (200 mL) and p-toluenesulfonic acid (1.72 g,10 mmol), stirred and dissolved.Then 3-bromo-1-propanol (13.90 g, 100 mmol) and 2,3-dihydropyran (12.60 g, 150 mmol) were added sequentially, and the reaction was stirred for 12 h.After the reaction was completed, it was quenched with water and the organic phase was separated.The aqueous phase was extracted with dichloromethane (3×100 mL). The organic phase was washed with aq. aq.Finally purified by silica gel column chromatography (petroleum ether / ethyl acetate 30:1).Obtained yellow-green oily liquid 1-tetrahydropyranyloxy-3-bromopropane 2(19.68 g, yield 88%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Patent; China Agricultural University; Zhong Jiangchun; Sun Xiao; Bian Qinghua; Wang Min; Zhou Yun; Yuan Gucheng; (7 pag.)CN109970534; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 5299-60-5, Ethyl 6-hydroxyhexanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5299-60-5, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H16O3

PREPARATION 280 To a solution of pyridinium chlorochromate (2.0 g) in dichloromethane (15 ml) was added a solution of 6-hydroxyhexanoic acid ethyl ester (1.0 g) in dichloromethane (1.5 ml) in one portion and stirred for 1.5 hours at ambient temperature. Ether (15 ml) was added to the reaction mixture, and the insoluble material removed by filtration and discarded. The filtrate was purified by silica gel chromatography (diethyl ether) to give 6-oxohexanoic acid ethyl ester (884.6 mg), as a pale green oil. IR (KBr): 2981.4, 2940.9, 2871.5, 2827.1, 2723.0, 1731.8, 1184.1 cm-1. NMR (CDCl3, delta): 1.26 (3H, t, J=7.1 Hz), 1.5-1.8 (4H, m), 2.2-2.6 (4H, m), 4.13 (2H, q, J=7.1 Hz), 9.77 (1H, t, J=1.6 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6884868; (2005); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7250-55-7, name is Dimethyl 3-hydroxypentanedioate, the common compound, a new synthetic route is introduced below. Product Details of 7250-55-7

Preparation 29: (l-methyl-5-oxo-pyrtOlidin-3-yl)-acetic acidStep A: 3-methanesulfonyloxy-pentanedioic acid dimethyl esterCommercially available methyl 3-hydroxy-pentanedioic acid dimethyl ester (3.5 g, 20 mmol) was dissolved in DCM (50 mL) and Et3N (5.6 mL, 40 mmol) was added thereto. The reaction solution was cooled to 0C, and MsCl (2.75 g, 24 mmol) was added dropwise thereto, followed by stirring at room temperature for 2 hours. After the reaction was complete, NH4Cl was added to the reaction solution, followed by extraction with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc: n-Hex = 1/5) to afford the title compound (4.77 g, 94%).MS[M+1] = 241 (M+l)

The synthetic route of 7250-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); A2;,
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