Electric Literature of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.
General procedure: The compounds 12 (A-G) were synthesized using a similar procedure. Monomethyl ester 7 (2.73 g, 10 mmol) was dissolved in 40 ml of CHCl3, and diluted thionyl chloride was added (1.1 ml, 15 mmol). The mixture was stirred at rt for 8 h. The volatile components were evaporated under reduced pressure, and the residue was dissolved in 20 ml of benzene and evaporated again. The residue was re-dissolved in 40 ml of CHCl3, and the resulting solution was added dropwise to the mixture of D-benzyl 2-hydroxy acetate 11(A-G) (10 mmol) and triethylamine (3.5 ml, 25 mmol) in 20 ml of CHCl3 at C. The solution was stirred at rt for 3 days (monitored with TLC: Petroleum ether/ethyl acetate, 2:1) and then washed successively with 1M NaOH, water, 5% HCl, water, 10% NaHCO3, and brine (25 ml of each). The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to offer crude products, which were was purified by flash column chromatography eluted with petroleum ether/ethyl acetate solution to afford the compounds 12 (A-G) as colorless or light yellow viscous liquid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.
Reference:
Article; Jia, Chao; Yang, Ke-Wu; Liu, Cheng-Cheng; Feng, Lei; Xiao, Jian-Min; Zhou, Li-Sheng; Zhang, Yi-Lin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 482 – 484;,
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