Category: 122-20-3

Li, Dandan published the artcileAminoalcohol-induced activation of organophosphorus hydrolase (OPH) towards diisopropylfluorophosphate (DFP), Name: Triisopropanolamine, the publication is PLoS One (2017), 12(1), e0169937/1-e0169937/23, database is CAplus and MEDLINE.

Aminoalcs. have been addressed as activating buffers for alk. phosphatase. However, there is no record on the buffer activation regarding organophosphorus hydrolase (OPH). Here we reported the activating effects of aminoalcs. on OPH-catalyzed hydrolysis of diisopropylfluorophosphate (DFP), an analog mol. of G-type warfare agents. The kinetic parametors kcat, Vmax and kcat/Km in the OPH reaction were remarkably increased in the buffers (pH 8.0, 25 °C) containing aminoalcs. with C2 between nitrogen (N) and oxygen (O) in their structures, including triethanolamine (TEA), diethanolamine, monoethanolamine, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and triisopropanolamine. In contrast, much lower or no rate-enhancing effects were observed in the adding of amines, alcs., amine/alc. mixtures, or 3-amino-1-propanol (C3 between N and O). The 300 mM TEA further increased DFP-degrading activities of OPH mutants F132Y and L140Y, the previously reported OPH mutants with desirable activities towards DFP. However, the treatment of ethylenediaminetetraacetate (EDTA) markedly abolished the TEA-induced activation of OPH. The product fluoride effectively inhibited OPH-catalyzed hydrolysis of DFP by a linear mixed inhibition (inhibition constant Ki ∼ 3.21 mM), which was partially released by TEA adding at initial or later reaction stage. The obtained results indicate the activation of OPH by aminoalc. buffers could be attributed to the reduction of fluoride inhibition, which would be beneficial to the hydrolase-based detoxification of organophosphofluoridate.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Name: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yanrong published the artcileA further understanding on the strength development of cement pastes in the presence of triisopropanolamine used in CRTS III slab track, Synthetic Route of 122-20-3, the publication is Construction and Building Materials (2022), 125743, database is CAplus.

Accelerators are commonly used in the self-compacting concrete of CRTS III slab track to advance its strength development in cold areas. Triisopropanolamine (TIPA) is a known accelerator, and its influences on the strength development of hardened cement pastes (HCPs) were discussed based on a further understanding of cement hydration and microstructure. The results show that the addition of TIPA visibly heightens hydration degree at each age because it triggers the reaction of C4AF and gently promotes C3S hydration. At low dosages, more hydrates deposited in capillary pores facilitate a refined pore structure and therefore, significantly increase the early and late strengths. On the contrary, a high dosage of TIPA results in a loose and porous structure at an early age owing to the emergence of numerous AFm platelets and the reduction of Ca(OH)₂ crystals, so that the heightened hydration degree only slightly increases the early compressive and flexural strengths. At a later age, high dosages of TIPA cause an increase in the volume of harmful pores (greater than 50 nm), which may result from the appearance of some pores full of fractional AFm and the changed morphol. of Ca(OH)₂. Therefore, the late compressive strength of HCPs remains almost unchanged under the pos. effect of the heightened hydration degree coupled with the neg. effect of the increased volume of the harmful pores. In contrast, the late flexural strength sharply decreases, which is ascribed to both of the increased volume of the pores larger than 50 nm and the morphol. changes of hydration products.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C24H20Ge, Synthetic Route of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Baoguo published the artcileEffect of triisopropanolamine on compressive strength and hydration of cement-fly ash paste, Recommanded Product: Triisopropanolamine, the publication is Construction and Building Materials (2018), 89-99, database is CAplus.

This paper aims to investigate the effect of triisopropanolamine (TIPA) on compressive strength and hydration of cement-fly ash paste. The samples with various dosages of TIPA were prepared with 30% fly ash (FA) and 70% cement (water/binder ratio by weight = 0.38), and cured under the standard condition. The compressive strength, pore structure, hydration process, and hydration products were investigated. The results show that TIPA can obviously increase the compressive strength of cement-FA system at the age of 7 d and 60 d, and the reasons are involved in pore structure and hydration of cement-FA system. Pore structure was characterized with mercury intrusion porosimetry, and the results show that TIPA can reduce total porosity but increase the amount of pore with size more than 50 nm, implying the air-entraining effect with neg. effect on compressive strength. The result suggests that TIPA and defoaming agent should be used together to minimize the neg. effect in real concrete. Furthermore, anal. of hydration products shows that TIPA can accelerate the hydration of both cement and FA, and this can also be illustrated from solid-state NMR. It is noticed that TIPA can hasten the conversion of AFt to AFm, which can be indicated from hydration heat. Addnl., the acceleration of pozzolanic reaction of FA is because TIPA can accelerate the dissolution of aluminate, silicate, and ferric into liquid paste which was demonstrated from morphol. characterization and the change of ions in pore solution Such results would be expected to provide experience for the use of alkanolamine in promoting the performance of cement-based materials.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yan published the artcileEffect of chemically modified recycled carbon fiber composite on the mechanical properties of cementitious mortar, Computed Properties of 122-20-3, the publication is Composites, Part B: Engineering (2019), 106853, database is CAplus.

Proper chem. treatment of recycled carbon fiber composites (RCFC) has been demonstrated to potentially add value to them, by improving the performance of cementitious materials incorporating them. This laboratory investigation mainly explored the use of saturated (simulated concrete) pore solution (SPS) to treat RCFC that contains cured epoxy resin, before its use in cementitious mortar. A total of seven mortar mixtures were fabricated, incorporating untreated RCFC, RCFC treated by SPS for different time periods followed by triisopropanolamine (TIPA), or RCFC treated by montmorillonite nanoclay emulsion (mNCE, at the nanoclay dosage of 0.75% by weight of cementitious binder). The water-to-binder (w/b) ratio of all mortar mixtures was 0.50 and the RCFC was admixed at 1% by volume The compressive strength and splitting tensile strength of RCFC reinforced mortar were evaluated. The chem. characterization (by FTIR), thermogravimetric anal., and microscopic investigation (by SEM) helped explain the observed engineering performance data. The residue epoxy resin on the surface of the RCFC was removed by the immersion in SPS, but a long-time treatment may result in damage of the fiber surface. The chem. treatment of RCFC showed both mech. and chem. benefits to its adhesion with the cementitious mortar. Admixing mNCE achieved outstanding strengths of the mortar similar to those of mortars treated by SPS for 0.5 h and then TIPA.

Composites, Part B: Engineering published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C18H35NO, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pianpian published the artcileMass production of a single-atom cobalt photocatalyst for high-performance visible-light photocatalytic CO₂ reduction, Formula: C9H21NO3, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2021), 9(46), 26286-26297, database is CAplus.

The photocatalytic reduction of carbon dioxide (CO₂RR) into value-added chem. products is a promising way to enrich energy supply and reduce CO₂ emission. The proposal of a high-efficiency, low-cost and easy-to-operate photocatalyst is an essential segment for promoting the CO₂RR from small-scale laboratory examination to large-scale industrial application. Herein, we first come up with a Co photocatalyst with isolated Co single atoms anchored on a com. super conductive carbon black (Co-SA@SP-800) and employ it to effectively boost the photocatalytic CO₂ reduction reaction. Large scale production of the Co-SA@SP-800 catalyst can be achieved by a simple and practical adsorption-pyrolysis method. The as-prepared Co-SA@SP-800 catalyst presents remarkable photoactivity and CO selectivity with a CO production yield of 1.64 x 104μmol g^-1 and a CO selectivity of 84.2% after 2 h of UV illumination in a heterogeneous system, and significantly outperforms other reference samples and most of the other efficient photocatalysts reported recently toward the conversion of CO₂. In situ diffuse reflectance IR Fourier transform (DRIFT) spectroscopy was carried out to investigate the reaction intermediates during the photocatalytic CO₂RR. Control experiments and theor. calculations revealed that the isolated single at. Co-N₄ sites greatly lower the energy barrier for the desorption of CO* during CO₂-to-CO conversion, while suppressing H₂ evolution in the competing water splitting reaction. This work provides valuable new insights for rationally designing and synthesizing high-performance single atom catalysts for photocatalytic CO₂ reduction with ease of large-scale production

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C5H6N2O2, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smirnov, Vladimir I. published the artcileCrystal and molecular structures of Si-(iodomethyl)silatranes with methyl substituents in β-position relative to the nitrogen atom, COA of Formula: C9H21NO3, the publication is Mendeleev Communications (2018), 28(3), 278-280, database is CAplus.

Crystal and mol. structures of two silatranes, 1-iodomethyl-3-methyl- and 1-iodomethyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecanes, were determined by X-ray anal. Comparison of their structural and geometrical characteristics with those of other silatranes shows that the presence of Me substituents β-positioned to nitrogen atoms increases the length of the dative Si←N bond, whereas the introduction of iodine into the axial position of the silatrane slightly decreases the length of the Si←N bond.

Mendeleev Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C16H20N2, COA of Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Juan published the artcileIntegrating disulfides into a polyethylenimine gene carrier selectively boosts significant transfection activity in lung tissue enabling robust IL-12 gene therapy against metastatic lung cancers, Quality Control of 122-20-3, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2021), 112358, database is CAplus and MEDLINE.

Bioreducible polyethylenimines (SSPEIs) are promising non-viral carriers for cancer gene therapy. However, the availability of significant gene transfection activity by SSPEIs remains a challenge. Herein, an essential step was taken to ascertain whether or not the disulfide bonds of SSPEIs play a critical role in promoting significant gene transfection activity in different tissues. Initially, a disulfide-linked linear polyethylenimine (denoted as SSLPEI) consisting of one 5.0 kDa LPEI main chain and three disulfide-linked 5.7 kDa LPEI grafts was designed and prepared to possess similar mol. weight with commercialized 25 kDa LPEI as a pos. control. The SSLPEI could induce superior in vitro transfection activity in different cells to the LPEI control as well as low cytotoxicity. Notably, such enhanced in vitro transfection effect by the SSLPEI was more marked in type-II alveolar epithelial cells compared to different cancer cells. In a Balb/c nude mouse model bearing SKOV-3 tumor, the SSLPEI caused parallel level of transgene expression with the LPEI control in the tumor but significantly higher level in the mouse lung. Furthermore, the SSLPEI and LPEI groups afforded an identical antitumor efficacy against the SKOV-3 tumor via i.v. delivery of a shRNA for silencing VEGF expression in the tumor. However, via i.v. delivery of an interleukin-12 (IL-12) gene into metastatic lung cancers in a C57BL/6 mouse model, the SSLPEI group exerted markedly higher IL-12 expression level in the mouse lung and peripheral blood as compared to the LPEI group, thereby boosting IL-12 immunotherapy against the lung metastasis with longer medium survival time. The results of this work elicit that the disulfide bonds of SSPEIs play a pivotal role in enhancing gene transfection activity selectively in the lung tissue rather than solid tumor, enabling high translational potential of SSPEIs for non-viral gene therapy against metastatic lung cancers.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Quality Control of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiao, Song published the artcileCore element characterization of Rhodococcus promoters and development of a promoter-RBS mini-pool with different activity levels for efficient gene expression, Application of Triisopropanolamine, the publication is New Biotechnology (2018), 41-49, database is CAplus and MEDLINE.

To satisfy the urgent demand for promoter engineering that can accurately regulate the metabolic circuits and expression of specific genes in the Rhodococcus microbial platform, a promoter-ribosome binding site (RBS) coupled mini-pool with fine-tuning of different activity levels was successfully established. Transcriptome analyses of R. ruber TH revealed several representative promoters with different activity levels, e.g., Pami, Pcs, Pnh, P50sl36, PcbiM, PgroE and Pniami. β-Galactosidase (LacZ) reporter measurement demonstrated that different gene expression levels could be obtained with these natural promoters combined with an optimal RBS of ami. Further use of these promoters to overexpress the nitrile hydratase (NHase) gene with RBSami in R. ruber THdAdN produced different expression levels consistent with the transcription analyses. The -35 and -10 core elements of different promoters were further analyzed, and the conserved sequences were revealed to be TTGNNN and (T/C)GNNA(A/C)AAT. By mutating the core elements of the strong promoters, Pnh and Pami, into the above consensus sequence, two even stronger promoters, PnhM and PamiM, were obtained with 2.2-fold and 7.7-fold improvements in transcription, resp.

New Biotechnology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Zifeng published the artcileTick-borne encephalitis virus nonstructural protein NS5 induces RANTES expression dependent on the RNA-dependent RNA polymerase activity, Recommanded Product: Triisopropanolamine, the publication is Journal of Immunology (2018), 201(1), 53-68, database is CAplus and MEDLINE.

Tick-borne encephalitis virus (TBEV) is one of the flaviviruses that targets the CNS and causes encephalitis in humans. The mechanism of TBEV that causes CNS destruction remains unclear. It has been reported that RANTES-mediated migration of human blood monocytes and T lymphocytes is specifically induced in the brain of mice infected with TBEV, which causes ensuing neuroinflammation and may contribute to brain destruction. However, the viral components responsible for RANTES induction and the underlying mechanisms remain to be fully addressed. In this study, we demonstrate that the NS5, but not other viral proteins of TBEV, induces RANTES production in human glioblastoma cell lines and primary astrocytes. TBEV NS5 appears to activate the IFN regulatory factor 3 (IRF-3) signaling pathway in a manner dependent on RIG-I/MDA5, which leads to the nuclear translocation of IRF-3 to bind with RANTES promoter. Further studies reveal that the activity of RNA-dependent RNA polymerase (RdRP) but not the RNA cap methyltransferase is critical for TBEV NS5-induced RANTES expression, and this is likely due to RdRP-mediated synthesis of dsRNA. Addnl. data indicate that the residues at K359, D361, and D664 of TBEV NS5 are critical for RdRP activity and RANTES induction. Of note, NS5s from other flaviviruses, including Japanese encephalitis virus, West Nile virus, Zika virus, and dengue virus, can also induce RANTES expression, suggesting the significance of NS5-induced RANTES expression in flavivirus pathogenesis. Our findings provide a foundation for further understanding how flaviviruses cause neuroinflammation and a potential viral target for intervention.

Journal of Immunology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C10H16Br3N, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Lijuan published the artcileAICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells, Category: alcohols-buliding-blocks, the publication is FASEB Journal (2019), 33(3), 4525-4537, database is CAplus and MEDLINE.

Here, we knocked out TP53 or PRKAA1 gene (encoding AMPKa1) in NALM-6 and Reh cells by using the clustered regularly interspaced short palindromic repeats/Cas9 system and found that AICAr-induced proliferation inhibition was independent of AMPK activation but dependent on p53. Liquid chromatog.-mass spectrometry anal. of nucleotide metabolites indicated that AICAr caused an increase in ATP, deoxyadenosine triphosphate, and deoxyguanosine triphosphate levels by up-regulating purine biosynthesis, while AICAr led to a decrease in cytidine triphosphate, uridine triphosphate, deoxycytidine triphosphate, and deoxythymidine triphosphate levels because of reduced phosphoribosyl pyrophosphate production, which consequently impaired the pyrimidine biosynthesis. Ribonucleoside triphosphate (NTP) pool imbalances suppressed the rRNA transcription efficiency. Furthermore, deoxy-ribonucleoside triphosphate (dNTP) pool imbalances induced DNA replication stress and DNA double-strand breaks, followed by cell cycle arrest and apoptosis in ALL cells. Exogenous uridine could rebalance the NTP and dNTP pools by supplementing pyrimidine and then attenuate AICAr-induced cytotoxicity. Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role in AICAr-mediated cytotoxic effects on ALL cells, suggesting a potential clin. application of AICAr in future ALL therapy.

FASEB Journal published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts