Category: 3391-10-4

Application of 3391-10-4 ,Some common heterocyclic compound, 3391-10-4, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of benzylic alcohol (10 mmol, 100 mol %) in CHCl3 was slowly added SOCl2 (14.5 mL, 200 mmol) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched with ice/H2O and neutralized with saturated NaHCO3 solution. The organic phase was collected and washed with brine three times, dried over Na2SO4 or MgSO4. After filtration and removal of the solvent under reduced pressure, the residue was purified by flash chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3391-10-4, 1-(4-Chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Qingchen; Wang, Xuan; Qian, Qun; Gong, Hegui; Synthesis; vol. 48; 17; (2016); p. 2829 – 2836;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 3391-10-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3391-10-4, name is 1-(4-Chlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: In a test tube, 1,3-dicarbonyl compound (1.5 mmol), alcohol or alkene (1.0 mmol) and catalyst (0.013 mmol) were mixed and stirred at 100 C for 5 h under solvent-free conditions. At the end of the reaction, Et2O (10 ml) was added and the catalyst was filtered. The pure product was isolated by chromatography on a silica gel plate (petroleum ether/ethylacatate = 9/1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3391-10-4, its application will become more common.

Reference:
Article; Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Catalysis Communications; vol. 29; (2012); p. 122 – 126;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts