The common heterocyclic compound, 138-22-7, name is Butyl 2-hydroxypropanoate, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 138-22-7
EXAMPLE 6 The procedure of Example 5 is followed, using n-butyl lactate (584 g, 4 mols) of optical rotation [alpha]D20 =-2.77 (without a solvent), thionyl chloride (512 g, 4.30 mols) and pyridine (1.2 g). The n-butyl lactate is run in at 60 C. in the course of 4 hours and this is followed by heating at 75 C. for 1 hour 15 minutes. After cooling under atmospheric pressure, a crude product (690 g) composed mainly of n-butyl 2-chloropropionate is recovered.
The synthetic route of 138-22-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rhone-Poulenc Agrochimie; US4334083; (1982); A;,
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