Category: 2009-83-8

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H13ClO

Chlorohexanol (71.9 mmol, 10.00 g), p-nitrophenol (86.4 mmol, 11.80 g), K2CO3 (109 mmol, 15.09 g), KI (5 mg), and DMF (80 mL) were added to a three-necked flask and refluxed at 120 C.After 6 hours of reaction, samples were taken for gas chromatography.When there is no peak of 6-chloro-1-hexanol in the gas phase, the reaction is stopped, and the mixed solution is poured into a large amount of water to obtain an off-white precipitate. After drying,Recrystallization from ethanol gave p-nitrophenoxyhexanol (Intermediate A) with a yield of about 87%.The purity by HPLC analysis was 95.2%.

With the rapid development of chemical substances, we look forward to future research findings about 2009-83-8.

Reference:
Patent; Changzhou University; Xue Xiaoqiang; Liang Kang; Jiang Bibiao; Huang Wenyan; Yang Hongjun; Jiang Qimin; Jiang Li; (20 pag.)CN110343079; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2009-83-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound [MA11-1] (50.00 g, 256 mmol) was added to a 2 L four-necked flask,6-chloro-1-hexanol (36.74 g,268 mmol), potassium carbonate (106.2 g, 768 mmol), potassium iodide (21.3 g, 128 mmol),DMF (500 g) was heated at 85C.Reaction tracing by HPLC,After confirming the end of the reaction,The reaction solution was poured into distilled water (3L).Filtration, washing with distilled water,Crude product was obtained.After that, the resulting crude product is washed with methanol and filtered.After drying under reduced pressure, 61.9 g of compound [MA11-2] was obtained (yield 82%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2009-83-8, 6-Chlorohexan-1-ol.

Reference:
Patent; Richan Chemical Industry Co., Ltd.; Gongli University Faren Bingku Li University; Hou Tenggengping; Shan Zhineiyangyi; Nan Wuzhi; Ming Mudazai; Wan Daichunyan; Lu Zeliangyi; Gen Mulongzhi; Ying Yetingdannierandongni; Sen Neizhengren; Chuan Yeyongtai; Chuan Yuexihong; Jin Tengruisui; (73 pag.)CN107473969; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2009-83-8 , The common heterocyclic compound, 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A three-necked reactor equipped with a condenser and a thermometer was charged with hydroquinone 104.77 g (0.9515 mol), 100 g (0.7320 mol) of 6-chlorohexanol, 500 g of distilled water and 100 g of o-xylene were added. While stirring the whole volume, 35.15 g (0.8784 mol) of sodium hydroxide was further added in small portions over 20 minutes so that the temperature of the contents did not exceed 40 C. After completion of the addition of sodium hydroxide, the contents were heated and the reaction was further carried out under reflux conditions (96 C.) for 12 hours After completion of the reaction, the temperature of the reaction solution was lowered to 80 C., 200 g of distilled water was added, and then the reaction solution was cooled to 10 C. to precipitate crystals. Precipitated crystals were separated by solid-liquid separation by filtration, and the obtained crystals were washed with 500 g of distilled water and vacuum dried to obtain 123.3 g of brown crystals. Analysis of this brown crystal by high performance liquid chromatography revealed that the content ratio (molar ratio) of the compound contained in the brown crystal is (hydroquinone / intermediate K / by-product K = 1.3 / 90.1 / 8. 1). This mixture was directly used for step 2 without purification.

The synthetic route of 2009-83-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; KIRIKI, SATOSHI; (83 pag.)JP2017/206490; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2009-83-8, 6-Chlorohexan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2009-83-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 2009-83-8

In addition, the mixture was stirred at a stirrer, condenser, and a reaction vessel provided with a thermometer 4-hydroxy-benzoic acid 13.8g (100 mmol), potassium iodide 2.5g, 0.7g tetrabutyl ammonium bromide, and 400ml of ethanol were charged at room temperature.It was added dropwise a 25% aqueous solution of sodium hydroxide, 12g slowly.After the addition, maintaining the reaction vessel at 50 , and was added dropwise to 6-chloro-hexanol 20g (150 mmol) slowly.After the addition was completed, the reaction vessel also by heating to 70 by further reaction for 3 hours.After completion of the reaction, neutralized with 10% hydrochloric acid and subjected to extraction with ethyl acetate, dried over sodium sulfate, the solvent was concentrated to 17g to synthesize compounds shown in formula (23).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2009-83-8, its application will become more common.

Reference:
Patent; DIC Corporation; Hayashi, Masanao; Nagashima, Yutaka; Kusumotto, Tetsuo; (24 pag.)KR101523330; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.

2.2 Preparation of 6-hydroxyhexyl 3,5-dinitrobenzoate 357.70 g (1.686 MoI) of 3,5-dinitrobenzoic acid are suspended in 750 ml of 1-methyl-2- pyrrolidone. The suspension is stirred up to 500C. 386.36 g (4.599 MoI) of sodium hydrogen carbonate are added and the mixture was heated up to 900C. 22.50 g (0.150 MoI) of sodium iodide and 204.0 ml (1.533 MoI) of 6-chlorohexanol are added to the reaction mixture which is heated to 1000C for 1 h. After 1 h of reaction, the reaction is complete and the orange suspension is thrown on 2 I of ice and1 I of water. The product is filtrated, washed water and dried at 5O0C under vacuum for 24 h to give 425.0 g (91%) of 6-hydroxyhexyl 3,5-dinitrobenzoate as a rose powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ROLIC AG; WO2008/145225; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2009-83-8, Adding some certain compound to certain chemical reactions, such as: 2009-83-8, name is 6-Chlorohexan-1-ol,molecular formula is C6H13ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2009-83-8.

To a 50 mL glass three-neck flask was added 2.72 g (0.01 mol) of 8-hydroxy-1,1,7,7-tetramethyljulonidine-9- Formaldehyde, 2.05 g (0.015 mol) 6-chloro-1-hexanol and 30 mL re-distilled N,N-dimethylformamide, add dry anhydrous potassium carbonate 1.7 g (0.012 mol) under N2 protection, at 120C The reaction was continued overnight . After the reaction was complete, the temperature was lowered. Potassium carbonate was removed by filtration. The filtrate was poured into water to obtain a dark blue solution, which was extracted three times with ethyl acetate. The organic phases were combined and the combined organic phases were dried over anhydrous magnesium sulfate and left overnight. , Filtration, rotary evaporation to remove ethyl acetate, the residue was separated by column chromatography (200-300 mesh silica gel as the stationary phase, with a mixture of n-hexane and ethyl acetate as the mobile phase, where: n-hexane and ethyl acetate The volume ratio was 7:1). After drying, a yellow solid was obtained as compound 1 in a yield of 61%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2009-83-8, 6-Chlorohexan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Zhen Zhen; Zhang Airui; Bo Shuhui; Liu Xinhou; Qiu Ling; Zhang Maolin; Xu Huajun; (21 pag.)CN104558005; (2018); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.

In a 500 mL two necked flask, 12.5 g (90 mmol) of K2CO3 and11.8 g (85 mmol) of 4-nitrophenol were measured and dissolvedin 200 mL of DMF. The solution was stirred and heated to 90 C,followed by the drop-wise addition of 100 mL DMF solution containing12.3 g (90 mmol) of 6-chlorohexanol. The temperature ofthe mixture was maintained at 90 C for 4 h. Then, the reactionmixture was allowed to cool to room temperature and subsequentlypoured into 1 L of distilled water in order to obtain a precipitate.The precipitate was filtered, washed with distilled waterand dried under vacuum. The product was recrystallised in 1:3 ratioof ethyl acetate-hexane mixed solvent. The solid product waspale yellow in color.Yield: 74%. Melting point: 66-67 C. IR (KBr, cm1): 3522(AOHstr), 2950 and 2860 (ACH2str), 1596 and 1504 (CCstr aromatic),1463 (ACHben), 1336 (ANO2str), 1260 and 1108 (CAOACstr).1H NMR ppm (CDCl3): d 8.13 (d, 2H), 6.89 (d, 2H), 4.00 (t, 2H), 3.63(t, 2H), 1.90 (bs, AOH), 1.79 (m, 2H), 1.56 (m, 2H), 1.45 (m, 4H). 13CNMR ppm (CDCl3): d 164.30, 141.32, 125.95, 114.47, 68.82, 62.74,32.63, 28.99, 25.81, 25.55. Elemental analysis: calcd. (%) forC12H17NO4: C 60.23, H 7.16, N 5.85; found: C 60.01, H 6.97, N 5.63.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Shanavas; Narasimhaswamy; Rotimi Sadiku; Journal of Molecular Structure; vol. 1054-1055; (2013); p. 18 – 24;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2009-83-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2009-83-8, name is 6-Chlorohexan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

I-a-4-3) (6 g, 43 mmol) p-hydroxybenzoic acid, (7.1 g, 52 mmol) chlorohexanol, (3.44 g, 86 mmol) sodium hydroxide,(0.7g, 4.3mmol) potassium iodide and 50mL water were added to a three-necked flask, heated to reflux, and refluxed for 4 hours,The temperature was lowered, hydrochloric acid was added to the reaction solution, the reaction solution was filtered, and the filter cake was recrystallized twice from ethyl acetate to obtain (6.1 g, 26 mmol) in a yield of 60%

According to the analysis of related databases, 2009-83-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shijiazhuang Cheng Zhiyonghua Display Materials Co., Ltd.; Zhao Lei; Meng Jingsong; Li Ming; Wei Tianyu; Yuan Guoliang; Liang Zhian; (27 pag.)CN110551078; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2009-83-8, Adding some certain compound to certain chemical reactions, such as: 2009-83-8, name is 6-Chlorohexan-1-ol,molecular formula is C6H13ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2009-83-8.

(1), in order to P-nitro phenol, 6- chlorine oneself alcohol and sodium hydroxide is used as a raw material, molar ratio of 1 : 1.2: 1.3, water as the solvent, 85 C reaction 6 hours to obtain P-nitrophenyl oxygen hexanol, after filtering first, solid for the removal of residual nitro phenol, filtered, the solid is dried in a vacuum oven, to obtain the product.Repeat embodiment 1 is the same as the steps in the operation of (2) (3) (4) (5) (6) (7) (8).

According to the analysis of related databases, 2009-83-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Changzhou University; Xue, Xiaoqiang; Jiang, Bibiao; Huang, Wenyan; Yang, Hongjun; (9 pag.)CN105732417; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 6-Chlorohexan-1-ol, 2009-83-8, Name is 6-Chlorohexan-1-ol, SMILES is OCCCCCCCl, in an article , author is Wang, Yaru, once mentioned of 2009-83-8.

Rational design of a porous nanofibrous actuator with highly sensitive, ultrafast, and large deformation driven by humidity

Humidity-responsive bilayered actuators which can dynamically change their shapes under humidity gradients, have recently motivated significant interest in a wide variety of emerging fields, including artificial muscles, intelligent sensors, and smart devices. However, this kind of actuators frequently suffer from slow responsiveness, prolonged actuating period, and small deformation, which is due to the dense structure hindering the diffusion of water molecules. Herein, we employ a simple programmable electrospinning approach to fabricate a highly porous polyvinyl alcohol/polyvinyl butyral (PVA/PVB) bilayered actuator for achieving excellent humidity-triggered deformation. Benefiting from the differential affinity of the two layers to water and the elaborately structural design, the porous bilayered actuator exhibits superior actuating performance in response to humidity gradient. Briefly, only 283 ms is needed for driving the shape change, and the whole deformation merely requires 10 s; besides, large bending amplitude with the curvature of 11.2 cm-1 is achieved, and the shape deformation process can be repeated at least 30 times without fatigue. Finally, we demonstrate the porous nanofibrous actuator can be used as artificial plants to perform opening and closing motions and a self-driven detector for monitoring humidity in real-time.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2009-83-8, you can contact me at any time and look forward to more communication. Recommanded Product: 6-Chlorohexan-1-ol.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts