Synthetic Route of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.
In a 500 mL two necked flask, 12.5 g (90 mmol) of K2CO3 and11.8 g (85 mmol) of 4-nitrophenol were measured and dissolvedin 200 mL of DMF. The solution was stirred and heated to 90 C,followed by the drop-wise addition of 100 mL DMF solution containing12.3 g (90 mmol) of 6-chlorohexanol. The temperature ofthe mixture was maintained at 90 C for 4 h. Then, the reactionmixture was allowed to cool to room temperature and subsequentlypoured into 1 L of distilled water in order to obtain a precipitate.The precipitate was filtered, washed with distilled waterand dried under vacuum. The product was recrystallised in 1:3 ratioof ethyl acetate-hexane mixed solvent. The solid product waspale yellow in color.Yield: 74%. Melting point: 66-67 C. IR (KBr, cm1): 3522(AOHstr), 2950 and 2860 (ACH2str), 1596 and 1504 (CCstr aromatic),1463 (ACHben), 1336 (ANO2str), 1260 and 1108 (CAOACstr).1H NMR ppm (CDCl3): d 8.13 (d, 2H), 6.89 (d, 2H), 4.00 (t, 2H), 3.63(t, 2H), 1.90 (bs, AOH), 1.79 (m, 2H), 1.56 (m, 2H), 1.45 (m, 4H). 13CNMR ppm (CDCl3): d 164.30, 141.32, 125.95, 114.47, 68.82, 62.74,32.63, 28.99, 25.81, 25.55. Elemental analysis: calcd. (%) forC12H17NO4: C 60.23, H 7.16, N 5.85; found: C 60.01, H 6.97, N 5.63.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Shanavas; Narasimhaswamy; Rotimi Sadiku; Journal of Molecular Structure; vol. 1054-1055; (2013); p. 18 – 24;,
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