Category: 7397-62-8

Adding a certain compound to certain chemical reactions, such as: 7397-62-8, Butyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 7397-62-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 7397-62-8

47.6 g (0.5 mol) of phenol, 134.2 g (1.04 mol) of butyl hydroxyacetate, and 0.36 g of catalyst Mo2P5-MCM-48 (molar ratio of Mo1P3 and MCM-48: 25:100) were mixed and stirred, and the temperature was raised to 100-120 C, the rectification water was reacted for 2 hours in this process. When the top of the column is substantially anhydrous, the reaction is completed, the temperature is lowered to room temperature, the catalyst is removed by suction filtration, the catalyst is continuously activated after the catalyst is activated, the obtained mother liquid is distilled to recover the solvent, and then the unsubstituted butyl hydroxyacetate and phenol are separated by distillation to obtain the product benzene. Butyl oxyacetate 69.6 g, purity 98.2%, selectivity 99.2%, yield 65.78%. The prepared butyl phenoxyacetate was detected by nuclear magnetic resonance, and the nuclear magnetic resonance spectrum was as shown in Fig. 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7397-62-8, Butyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; He Enjing; Hu Yishan; (8 pag.)CN108947841; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7397-62-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7397-62-8, name is Butyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

The esterification of metharylic acid with BG was done by carbonyl diimidazole coupling. 1 Eq. of methacrylic acid was charged into suitable sized round bottom flask (RBF) with a stir bar. 10 volumes of dichloromethane was then added to it. RBF was then sealed with a rubber septa and the mixture of methacrylic acid and dichloromethane was then flushed with N2 for 5 minutes. The RBF was then placed in an ice bath until the contents cooled down to 0C. Then CDI was then added to the reaction through the mouth of the RBF by removing the septa. Frothing was observed in the reactor. Once the frothing stopped, the reaction vessel was sealed by rubber septa and butyl glycolate was added using a syringe. The ice bath was removed and the reaction allowed to run at room temperature. It was followed by thin layer chromatography (TLC) on silica using 2% isopropanol/98% chloroform and separately using chloroform/methanol/acetic acid (CMA) 98: 2:2. No spot for carbonyl diimidazole was observed after 2.5 hrs. The spot for the compound overlaps with that of carbonyl diimidazole in the TLC done using 2% isopropanol, but a distinct spot was seen for the compound in the TLC done with CMA. Once the reaction was complete, the solvent was removed in vacuo and the sample was purified by column chromatography. The yield was approximately 20%.

According to the analysis of related databases, 7397-62-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY OF UTAH RESEARCH FOUNDATION; WO2005/97210; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7397-62-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7397-62-8, name is Butyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

The esterification of metharylic acid with BG was done by carbonyl diimidazole coupling. 1 Eq. of methacrylic acid was charged into suitable sized round bottom flask (RBF) with a stir bar. 10 volumes of dichloromethane was then added to it. RBF was then sealed with a rubber septa and the mixture of methacrylic acid and dichloromethane was then flushed with N2 for 5 minutes. The RBF was then placed in an ice bath until the contents cooled down to 0C. Then CDI was then added to the reaction through the mouth of the RBF by removing the septa. Frothing was observed in the reactor. Once the frothing stopped, the reaction vessel was sealed by rubber septa and butyl glycolate was added using a syringe. The ice bath was removed and the reaction allowed to run at room temperature. It was followed by thin layer chromatography (TLC) on silica using 2% isopropanol/98% chloroform and separately using chloroform/methanol/acetic acid (CMA) 98: 2:2. No spot for carbonyl diimidazole was observed after 2.5 hrs. The spot for the compound overlaps with that of carbonyl diimidazole in the TLC done using 2% isopropanol, but a distinct spot was seen for the compound in the TLC done with CMA. Once the reaction was complete, the solvent was removed in vacuo and the sample was purified by column chromatography. The yield was approximately 20%.

According to the analysis of related databases, 7397-62-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY OF UTAH RESEARCH FOUNDATION; WO2005/97210; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 3-neck, 50 mL flask (equipped with a thermocouple, magnetic stirrer, heating mantle, reflux condenser, and N2 purge) was added the intermediate (4) from Part B (1.0 g, 2.79 mmol), ethylene glycol (7.0 g), [1,] 8-diazabicyclo [5.4. 0] undec-7-ene (“DBU”, 42 mg, 0.28 mmol, 0.1 equivalents relative to the intermediate (4) ), and butyl glycolate (5) (1.1 g, 8. [38] mmol, 3.0 equivalents relative to the intermediate (4) ). The resulting white slurry was heated to [80C,] and then stirred at this temperature for 4.9 hr. Although the slurry initially formed a light yellow solution during this heating, it formed a clear solution after 40 min of heating. Following the 4.9 hr heating period, deionized water was added over a 15 min period in an amount such that the mixture became slightly turbid. During this water addition, the temperature was maintained at [80C.] The resulting mixture was stirred for another hour at this temperature, and then allowed to cool naturally to room temperature. The resulting precipitate was filtered, washed with water [(2X10] mL), and air-dried for 1.3 hr to afford 1.10 g of light yellow crystals. Liquid chromatography analysis comparing these crystals with a pre-formed standard indicated the formation of the desired product (6).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/104223; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

59.23 g of 99.5% magnesium ethoxide was added to the obtained n-butyl glycolate, and the alcohol formed by the reaction was simultaneously removed at 60 C. After the reaction, 154.42 g of 99% o-dichlorobenzene was added thereto, and the condensation reaction was carried out at 90 C. After the reaction, the unreacted o-dichlorobenzene was decompressed under reduced pressure, and the condensation liquid was cooled to 35 C for filtration. The filter cake was dried under reduced pressure, and the dried fraction was collected and combined with the filtrate to obtain n-butyl o-chlorophenoxyacetate (243.96 g). The content is 98.4%, and the yield is 98.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Chi Zhilong; Hou Yongsheng; Zhang Liguo; Hu Yishan; (8 pag.)CN108947816; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7397-62-8, name is Butyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H12O3

a1 n-Butyl (t-butyl-dimethyl-silanyloxy)-acetate n-Butyl glycolate (231 g; 1.75 mol) and imidazole (345.1 g; 5.07 mol) are placed together at 0 C. The suspension obtained was treated portionwise with t-butyldimethylchlorosilane (303 g; 2.01 mol) during 1.5 hours. After 20 hours at room temperature the reaction mixture was diluted with ether/n-hexane 1:1 (1 l) and suction filtered. The crystals were rinsed thoroughly with ether/n-hexane 1:1 (200 ml). The filtrate was washed in succession with water (2*700 ml) and saturated aqueous sodium chloride solution (500 ml), dried over magnesium sulphate and concentrated. The oil obtained was distilled over a Vigreux column (7.5 cm). Yield: 405 g (94%) as a colourless oil (b.p. 78 C./0.98 mmHg). IR (film): 1760, 1225, 1206, 1148, 838, 780 cm-1 MS (EI): (M+H)+ 247

With the rapid development of chemical substances, we look forward to future research findings about 7397-62-8.

Reference:
Patent; Hoffmann-La Roche Inc.; US5464617; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example II-a-1 CH3 SO2 OCH2 COO-nC4 H9 27.8 g (0.2 mol) of n-butyl hydroxyacetate (95% pure by GC) and 20.2 g (0.2 mol) of triethylamine are first introduced into 300 ml of dichloromethane at -5 C. 34.4 g (0.3 mol) of methanesulfonyl chloride in 50 ml of dichloromethane are slowly added dropwise at 0 to 5 C. Stirring of the batch at 0 C. is continued overnight, ice water is added, the phases are separated, and the aqueous phase is extracted twice with dichloromethane. The combined organic phases are dried, and the solvent is removed on a rotary evaporator leaving a colorless oil which is subjected to incipient distillation in vacuo. n-Butyl methylsulfonyloxyacetate is isolated as an almost colorless oil (40.5 g, 96.3% of theory, GC content 91%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US5698735; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7397-62-8, name is Butyl 2-hydroxyacetate, molecular formula is C6H12O3, molecular weight is 132.16, as common compound, the synthetic route is as follows.Recommanded Product: 7397-62-8

EXAMPLE 4 A suspension of 3-chloro-2-(2,4-difluoro-5-nitrophenyl)-4,5,6,7-tetrahydro-2H-indazole (10 g), butyl glycollate (5 g) and potassium fluoride (10 g) in dioxane (30 g) was refluxed for 1 hour. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated. The residue was purified by liquid column chromatography using a mixture of hexane and ethyl acetate as an eluent to give 3-chloro-2-(2-fluoro-4-butyloxycarbonylmethoxy-5-nitro-phenyl)-4,5,6,7-tetrahydro-2H-indazole (10.2 g). m.p., 138-139 C. 1 H-NMR (delta, CDCl3): 0.92 (t, 3H, J=6 Hz), 1.1-2.1 (br, 8H), 2.1-2.9 (br, 4H), 4.2 (t, 2H, J=6 Hz), 4.8 (s, 2H), 6.82 (d, 1H, J=11 Hz), 8.03 (d, 1H, J=8 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7397-62-8, Butyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4877444; (1989); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7397-62-8, Adding some certain compound to certain chemical reactions, such as: 7397-62-8, name is Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7397-62-8.

175.16 g (99%) of o-cresol and 214.10 g (99%) of n-butyl glycolate,And the catalyst Mo2P5-MCM-48 (Mo2P5 and MCM-48 mass ratio of 25:100) 1.32g was put into the reaction rectification apparatus, mixed and stirred, and the temperature was raised to 120 C, and the reaction was carried out for 3 hours.When the top of the column is substantially anhydrous, the reaction is completed, the temperature is lowered to room temperature, the catalyst is filtered off, and the filtrate is distilled to recover 64.85 g of o-cresol.a mixture of 48.94 g of n-butyl glycolate, 118.54 g,The product obtained n-butyl tolyloxyacetate 223.82g, purity 98.9%,The yield was 99.2% based on phenol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; Zhang Liguo; Hu Yishan; (13 pag.)CN108947839; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 7397-62-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7397-62-8 as follows.

Example 36 Butyl 3-amino-6-benzyl-5,6,7,8-tetrahydro-4H-furo[2,3-d]azepine-2-carboxylate A solution of 1.0 gm (0.008 mol) of butyl glycolate in 8 ml of absolute dioxane was added dropwise to a suspension of 0.4 gm (0.008 mol) of 50% sodium hydride in 5 ml of absolute dioxane, and the mixture was stirred for one hour at room temperature. Then, while the mixture was cooled with ice, a solution of 1.0 gm (0.004 mol) of 1-benzyl-4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-azepine in 15 ml of absolute dioxane was added, and the mixture was stirred for one hour. The reaction mixture was then poured into about 80 ml of ice-cold water, and the aqueous mixture was extracted three times with ethyl acetate. The combined organic phases were washed twice with water, dried over sodium sulfate and concentrated by evaporation. The residue was purified by column chromatography on silicagel, using toluene/ethyl acetate (7:3) as eluant. Yield: 0.2 gm (14% of theory). Melting point: <20 C. Calc.: molecular peak m/e=342. Found: molecular peak m/e=342. These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common. Reference:
Patent; Dr. Karl Thomae Gesellschaft mit beschrankter Haftung; US4414225; (1983); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts