Reference of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a 3-neck, 50 mL flask (equipped with a thermocouple, magnetic stirrer, heating mantle, reflux condenser, and N2 purge) was added the intermediate (4) from Part B (1.0 g, 2.79 mmol), ethylene glycol (7.0 g), [1,] 8-diazabicyclo [5.4. 0] undec-7-ene (“DBU”, 42 mg, 0.28 mmol, 0.1 equivalents relative to the intermediate (4) ), and butyl glycolate (5) (1.1 g, 8. [38] mmol, 3.0 equivalents relative to the intermediate (4) ). The resulting white slurry was heated to [80C,] and then stirred at this temperature for 4.9 hr. Although the slurry initially formed a light yellow solution during this heating, it formed a clear solution after 40 min of heating. Following the 4.9 hr heating period, deionized water was added over a 15 min period in an amount such that the mixture became slightly turbid. During this water addition, the temperature was maintained at [80C.] The resulting mixture was stirred for another hour at this temperature, and then allowed to cool naturally to room temperature. The resulting precipitate was filtered, washed with water [(2X10] mL), and air-dried for 1.3 hr to afford 1.10 g of light yellow crystals. Liquid chromatography analysis comparing these crystals with a pre-formed standard indicated the formation of the desired product (6).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/104223; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts