Category: 7218-43-1

Reference of 7218-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol, molecular formula is C7H12O3, molecular weight is 144.1684, as common compound, the synthetic route is as follows.

General procedure: Freshly ground potassium hydroxide (2 eq.) was added to a cooled (0 C) solution of S1 inanhydrous DCM under a nitrogen atmosphere. The mixture was then stirred at this temperature for an hour before the slow addition of p-toluene sulfonylchloride (1.1 eq.). The reaction mixture was thenstirred at room temperature overnight before being concentrated in vacuo to give a beige oily solid.The crude product was then taken up in EtOAc (25 mL) and the resulting suspension stirred at roomtemperature for 30 minutes. The insoluble solid was removed by filtration and the filtrate concentratedin vacuo to afford S2.

The chemical industry reduces the impact on the environment during synthesis 7218-43-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Tran, Fanny; Odell, Anahi V.; Ward, Gary E.; Westwood, Nicholas J.; Molecules; vol. 18; 9; (2013); p. 11639 – 11657;,
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Reference of 7218-43-1 ,Some common heterocyclic compound, 7218-43-1, molecular formula is C7H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

120mg NaH (60%) was added to a solution of 144mg 1-propargyl diethylene glycol in 5mL THF,Stir at room temperature for 15 minutes, then add 152 mg of bromoacetic acid and heat to reflux for 6 hours.After the reaction was completed, 10 mL of saturated ammonium chloride solution was added to quench the reaction, and the organic phase was separated.The aqueous phase was extracted three times with dichloromethane and incorporated into the organic phase,It was washed successively with saturated aqueous ammonium chloride solution and saturated brine, and then dried over anhydrous sodium sulfate,The sodium sulfate was removed by filtration and concentrated to obtain the crude product.The crude product was isolated by column chromatography (200-300 mesh silica gel, eluent dichloromethane: methanol = 50: 1) to obtain pure intermediate 26.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ShanghaiTech University; Tao Houchao; Zhao Fei; (85 pag.)CN110894209; (2020); A;,
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Synthetic Route of 7218-43-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol. This compound has unique chemical properties. The synthetic route is as follows.

(Wurz, R. P.; et al., “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. Journal of medicinal chemistry 2018, 61, 453-461). The method, as described by Oberborsch was used to prepare this compound (WO2009124746 Al). To a solution of the alcohol SR3-062 (3.00 g, 20.81 mmol) and n-Bu4NCl (1.908 g, 6.867 mmol) in DCM (102 mL) at 0 C were added NaOH (102 mL, aq. 35%) and ieri-butyl bromoacetate (9.225 mL, 62.427 mmol). The mixture was stirred at room temperature for 5 h and diluted with DCM (25 mL) and water (25 mL). The layers were separated and the organic layer washed with water (2 x 20 mL), brine (1 x 20 mL), dried (Na2S04), and evaporated in vacuo. Purification by flash column chromatography using EtOAc:hexane (5-50%) as eluent afforded SR3-066 (Wurz, R. P.; et al., “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. Journal of medicinal chemistry 2018, 61, 453-461) as a pale- yellow oil (4.724 g, 87%). NMR (500 MHz, Chlorol’orn /) d 4.23 (d, J = 2.4 Hz, 2H), 4.05 (s, 2H), 3.79-3.65 (m, 8H), 2.45 (t, J = 2.4 Hz, 1H), 1.50 (s, 9H). 13C NMR (126 MHz, CDCh) d 169.7, 81.5, 79.7, 74.5, 70.7, 70.6, 70.4, 69.1, 69.1, 58.4, 28.1. HRMS (ESI+): m/z calcd for C13H23O5 (M+H)+ 259.1540, found 259.1547, m/z calcd for Ci3H2205Na (M+Na)+ 281.1359, found 281.1365. HPLC-MS (ESI+): m/z 281.2 [100%, (M+Na)+]

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; BURNETTE, Pearlie; LAWRENCE, Nicholas J.; LAWRENCE, Harshani; (0 pag.)WO2020/14489; (2020); A2;,
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Adding a certain compound to certain chemical reactions, such as: 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7218-43-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7218-43-1

Intermediate 3: 2-(2-(prop-2-ynyloxy)ethoxy)ethylcarbamateTo a solution of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-ol (8.99 mmol) in dry DCM (50 ml), was added2,2,2-trichloroacetyl isocyanate (10.79 mmol) at 0 C. After 1 hour stirring at room temperature, thesolvent was evaporated and the reaction mixture was dissolved in 30 ml MeOH en 3 ml Water. K2C03(15.46 mmol) was added and the reaction was allowed to stir overnight. MeOH was evaporated andwater (50 ml) was added. This water layer was extracted twice with EtOAc. The organic layers were combined, washed with brine, dried over anhydrous Na2SO4, filtered and evaporated. A yellow oily liquid was obtained.Yield: 74% (1.2 g), MS (ESI) m/z 226 [M÷K]1H-NMR (ODd3, 400 MHz)6 2.40 (t, J=2.4 Hz, 1H), 3.65 (m, 6H), 4.20 (m, 4H), 4.90 (brs, 2H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITEIT ANTWERPEN; JOOSSENS, Jurgen; AUGUSTYNS, Koen; LAMBEIR, Anne-Marie; VAN DER VEKEN, Pieter; VAN SOOM, Jeroen; MAGDOLEN, Viktor; (66 pag.)WO2015/144933; (2015); A1;,
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Reference of 7218-43-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol. A new synthetic method of this compound is introduced below.

A suspension of Intermediate B (190 mg, 0.297 mmol), 2-(2-(prop-2-yn-1-yloxy)ethoxy) ethanol [King-Underwood et al., WO2011/048111] (257 mg, 0.890 mmol), PdCI2(PPh3)2 (208 mg, 0.297 mmol) and copper(l) iodide (57 mg, 0.30 mmol) in a mixture of Et2NH and DMF (4: 1 v/v, 7.5 ml_) was degassed with N2 and was then heated to 60C for 16 hr. The reaction mixture was cooled to RT and was evaporated in vacuo onto silica gel and purified by flash column chromatography (Si02, 12 g, MeOH in DCM, 0-5%, gradient elution) to afford the title compound, Compound (la), as a pale tan solid (30 mg, 14%); Rt 1.88 min, m/z 704 (M+H)+ (ES+); 1 H NMR delta: 3.36-3.50 (6H, overlapping m), 3.61-3.63 (2H, overlapping m), 4.37 (2H, s), 4.58 (1 H, m), 5.48 (2H, s), 5.76 (2H, s), 6.41 (1 H, d), 6.64 (1 H, m), 6.72 (1 H, d), 6.78 (1 H, s), 7.14 (1 H, t), 7.27 (1 H, t), 7.52 (1 H, d), 7.65-7.71 (2H, overlapping m), 7.82 (1 H, t), 8.13 (1 H, s), 10.19 (1 H, br s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.

Reference:
Patent; RESPIVERT LIMITED; ONIONS, Stuart Thomas; COPMANS, Alex Herman; BROECKX, Rudy Laurent Maria; SMITH, Alun John; TADDEI, David Michel Adrien; WO2014/140597; (2014); A1;,
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Related Products of 7218-43-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7218-43-1 as follows.

Weigh 200mg of 1-adamantanacetic acid, dissolve it in 3mL of dichloromethane, add DCC, DMAP successively under ice bath, stir for 30min under ice bath, add 156mg of intermediate 6, The reaction was performed at room temperature for 5 hours. After the reaction was detected to be complete by LC-MS, the insoluble matter was removed by filtration, and dichloromethane (20 mL x 3) was added. Extracted twice with 20 mL of saturated sodium bicarbonate, dried by adding anhydrous MgSO4 for 5 h, filtered with suction, and purified by column chromatography under reduced pressure to obtain 180 mg of intermediate H-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.

Reference:
Patent; Zhengzhou University; Ke Yu; Xie Hang; Liu Hongmin; Xu Xia; Liang Jianjia; (25 pag.)CN110759897; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 7218-43-1, Adding some certain compound to certain chemical reactions, such as: 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol,molecular formula is C7H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7218-43-1.

Weigh 1g of compound 44 in 50mL of dichloromethane, add 1.4g of triethylamine and 2.1g of p-nitrophenyl chloroformate, stir overnight at room temperature, and concentrate by column chromatography to obtain 603mg of compound 45, yield 28.1% .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tagete Bio-pharmaceutical Technology Co., Ltd.; Xie Yongmei; Zhao Yu; Luo Bo; (38 pag.)CN110845559; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts