Adding a certain compound to certain chemical reactions, such as: 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7218-43-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7218-43-1
Intermediate 3: 2-(2-(prop-2-ynyloxy)ethoxy)ethylcarbamateTo a solution of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-ol (8.99 mmol) in dry DCM (50 ml), was added2,2,2-trichloroacetyl isocyanate (10.79 mmol) at 0 C. After 1 hour stirring at room temperature, thesolvent was evaporated and the reaction mixture was dissolved in 30 ml MeOH en 3 ml Water. K2C03(15.46 mmol) was added and the reaction was allowed to stir overnight. MeOH was evaporated andwater (50 ml) was added. This water layer was extracted twice with EtOAc. The organic layers were combined, washed with brine, dried over anhydrous Na2SO4, filtered and evaporated. A yellow oily liquid was obtained.Yield: 74% (1.2 g), MS (ESI) m/z 226 [M÷K]1H-NMR (ODd3, 400 MHz)6 2.40 (t, J=2.4 Hz, 1H), 3.65 (m, 6H), 4.20 (m, 4H), 4.90 (brs, 2H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITEIT ANTWERPEN; JOOSSENS, Jurgen; AUGUSTYNS, Koen; LAMBEIR, Anne-Marie; VAN DER VEKEN, Pieter; VAN SOOM, Jeroen; MAGDOLEN, Viktor; (66 pag.)WO2015/144933; (2015); A1;,
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