As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14002-73-4, name is Ethyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C7H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks
A solution of distilled sulfuryl chloride (0.55 mL, 7.5 mmol) in Et2O (10 mL) was cooled to -78 C. under an atmosphere of argon. A solution of ethyl 3-hydroxy-2,2-dimethylpropanoate (2a) (1.0 g, 6.8 mmol) and pyridine (0.55 mL, 6.8 mmol) in Et2O (1.0 mL) was then added dropwise over 1 h via a syringe. The syringe was rinsed with Et2O (3¡Á1 mL), each rinse being added to the reaction mixture. The acetone/CO2 bath was removed, and the mixture was allowed to warm to room temperature, then stirred at room temperature for 4 h. TLC analysis (EtOAc/hexanes; 3:7) did not indicate that the reaction was complete. The mixture was re-cooled to -78 C. and more SO2Cl2 (0.11 mL) was added, and the mixture allowed to warm to room temperature and stirred for an additional 2 h. The mixture was filtered and the filtrate was concentrated under vacuum to give the product (yield assumed quantitative). 1H NMR (300 MHz, CDCl3): delta 4.50 (s, 2H), 4.19 (q, J=6.9 Hz, 2H), 1.31 (s, 6H), 1.28 (t, J=6.9 Hz, 3H)
With the rapid development of chemical substances, we look forward to future research findings about 14002-73-4.
Reference:
Patent; ARIXA PHARMACEUTICALS, INC.; Gordon, Eric M.; Freund, John; Gallop, Mark A.; Duncton, Matthew Alexander James; (117 pag.)US10085999; (2018); B1;,
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