The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16297-94-2, name is 3-(3-Methyl-3H-diazirin-3-yl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
Intermediate 1 was dissolved with 40 mL of dichloromethane, then 3 mL of triethylamine was added.Then, p-toluenesulfonyl chloride (2.86 g, 15 mmol) was slowly added to the reaction solution.The reaction was stirred at room temperature overnight. After the reaction was completed, 1N HCl was added to the reaction solution. The organic phase is separated and the aqueous phase is extracted with dichloromethane. The combined organic phases were washed first with 1 N HCl and then with 1 N NaOH.Dry over anhydrous sodium sulfate and concentrate.The product was purified by silica gel column to give Intermediate 2 (2.2 g, yield 82%).
With the rapid development of chemical substances, we look forward to future research findings about 16297-94-2.
Reference:
Patent; Peking University; Zhou Demin; Si Longlong; Zhang Ziwei; Han Xu; Meng Kun; Zhang Bo; Xiao Sulong; Zhang Lihe; Zhou Xueying; (24 pag.)CN107304221; (2017); A;,
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