Category: 75853-18-8

Application of 75853-18-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75853-18-8, name is 2,3-Difluorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of (2,3-difluoro-phenyl)-methanol (50 g, 0.35 mol, 1.0 eq) and imidazole (70.9 g, 1.05 mol, 3.0 eq) in dry THF (1 L) was added TBDMSCI (62.7 g, 0.42 mol, 1.2 eq) at ice-bath. After stirring at rt for 3 h, the mixture was extracted with EA, and washed with water and 0.5 N HC1. The organic layer was dried over Na2S04 and evaporated to give the crude product was directly used in next step.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 75853-18-8, 2,3-Difluorobenzyl alcohol.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75853-18-8, name is 2,3-Difluorobenzyl alcohol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.SDS of cas: 75853-18-8

tert-Butyl-(2,3-difluoro-benzyloxy)-dimethyl-silane To a solution of (2,3-difluoro-phenyl)-methanol (5.0 g, 35 mmol), imidazole (4.9 g, 72 mmol) and DMF (40 mL) was added tert-butyldimethylchlorosilane (5.4 g, 36 mmol). After stirring at ambient temperature for 24 hours, the mixture was partitioned between 400 mL of ether and 100 mL of water. The organic layer was washed twice with water, dried over MgSO4, filtered and concentrated in vacuo, affording 6.8 g of tert-butyl-(2,3-difluoro-benzyloxy)-dimethyl-silane as a colorless oil. 1H NMR (400 MHz, CDCl3) delta7.22 (m, 1H), 7.04 (m, 2H), 4.79 (s, 2H), 0.91 (s, 9H), 0.12 (s, 6H) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75853-18-8, 2,3-Difluorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US6235764; (2001); B1;,
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Adding a certain compound to certain chemical reactions, such as: 75853-18-8, 2,3-Difluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,3-Difluorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,3-Difluorobenzyl alcohol

Solid NaH (17 mg, 0.7 mmol, 7 eq. ) was added to a stirred solution of 2, 3-difluorobenzyl alcohol (0.10 g, 0.7 mmol, 7 eq. ) in dry benzene (5 mL) at 0 °C The solution was allowed to reach RT over 15 min. The product from step (a) (45 mg, 0.1 mmol, 1 eq. ) was added as a solid and the mixture was heated to reflux for 1 h. After cooling to RT, the reaction was quenched by addition of saturated aqueous NH4C1 (1 mL). The mixture was partitioned between EtOAc (10 ML) and water (10 mL). The organic phase was separated, dried over NA2S04 and evaporated. The oily residue was purified by preparative HPLC to give the title compound as an off-white solid (4.5 mg, 11 percent yield). IH NMR (CDCl3) 8 9.80-9. 20 (br s, 1H), 7.80 (s, 1H), 7.69-7. 29 (m, 3H), 6.50 (m, 1H), 5.49 (s, 2H), 4.41 (m, 1H), 3.78 (dd, 1H), 3.64 (dd, 1H), 1. 68-1. 48 (m, 3H), 0.95 (d, 3H), 0.91 (d, 3H); MS (EST) 7N/Z 406 [M+H].

The synthetic route of 75853-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2005/33115; (2005); A1;,
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Electric Literature of 75853-18-8 , The common heterocyclic compound, 75853-18-8, name is 2,3-Difluorobenzyl alcohol, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 73 2,3-Difluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2,3-difluorobenzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a white solid (0.1846 g, 57percent overall); (Found: C, 52.4; H, 6.0; N, 8.6percent. C14H18F2N2O2.HCl requires C, 52.4; H, 6.0; N, 8.7percent); deltaH (400 MHz, DMSO-d6) 10.07 (1H, br), 9.33 (1H, br), 7.44 (1H, m), 7.28 (2H, m), 5.21 (2H, s), 4.30 (2H, m), 3.14 (2H, d, J 13.2 Hz), 3.06 (2H, m), and 1.31(6 H, d, J 7.2 Hz).

The synthetic route of 75853-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Davidson, James Edward Paul; Dawson, Claire Elizabeth; George, Ashley Roger; Mansell, Howard Langham; Mattei, Patrizio; Mizrahi, Jacques; Nettekoven, Matthias Heinrich; Pratt, Robert Mark; Roever, Stephan; Roffey, Jonathan Richard Anthony; Specklin, Jean-Luc; Stalder, Henri; Wilkinson, Kerry; US2002/143020; (2002); A1;,
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Electric Literature of 75853-18-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75853-18-8, name is 2,3-Difluorobenzyl alcohol. A new synthetic method of this compound is introduced below.

Example 218: 4-[2-(2,3-Difluorobenzyloxy)ethyl]piperidine-l-carboxylic acid tert-butyl esterA stirred solution of (2,3-difluorophenyl)methanol (50 mg, 350 mumol) in anhydrous THF (2 mL) was treated with tBuOK (47 mg, 42 mumol) and then 4-(2-methanesulfonyloxy- ethyl)piperidine-l-carboxylic acid tert-butyl ester (Preparation 10) was added. The resulting mixture was heated under reflux for 12 h, cooled and poured into saturated aqueous NH4Cl, and extracted with EtOAc (20 mL). The organic phase was washed with brine (5 mL), dried (MgSO4) and evaporated. The residue was purified by column chromatography (IH-EtOAc, 4: 1) to afford the title compound: RT = 4.39 min; m/z (ES+) = 356.1 [M+ H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75853-18-8, 2,3-Difluorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; PROSIDION LIMITED; WO2007/3962; (2007); A2;,
Alcohol – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75853-18-8, name is 2,3-Difluorobenzyl alcohol, the common compound, a new synthetic route is introduced below. Formula: C7H6F2O

In a 5 ml quartz glass reaction tube,0.1 mmol of 2,3-difluorobenzyl alcohol was added, and 20 mg of Zn0.6In2S3.6 was weighed to catalyze the reaction, and 1.0 ml of acetonitrile was added thereto, The reaction tube was replaced with argon gas and sealed, and the ambient temperature 6W LED illumination was 36h. and the reaction was completed. The product was chromatographed and the mass spectrum showed a molecular weight consistent with 2,2′,3,3′-tetrafluorodiphenylethanone, and the yield was 75.5percent.

The synthetic route of 75853-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dalian Institute of Chemical Physics; Wang Feng; Luo Nengchao; Wang Min; Hou Tingting; Chi Rihan; Li Hongji; Liu Huifang; (10 pag.)CN108440259; (2018); A;,
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