Category: 117087-18-0

Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 117087-18-0, blongs to alcohols-buliding-blocks compound. Product Details of 117087-18-0

White powder obtained in the step (3) (75 g, 0.38 mol)Soluble in N,N-dimethylformamide (1L), ice bath,Nitrogen partial protection,One copy Sodium hydrogen(15.2g, 0.38mol, 60% in mineral oil),After stirring for 1 hour, methanesulfonyl chloride (43 g, 0.375 mol) was added dropwise.The system was allowed to warm to room temperature and stirring was continued for 2 hours.Then the system is cooled to 0 C,Add one part of sodium hydrogen (15.2g, 0.38mol),The system was slowly warmed to room temperature again and stirring was continued for 3 hours.In the ice bath, adding 1M means adjusting the pH to neutral.Add 2L of water, extract ethyl acetate 300mL 5 times,The organic phases were combined, washed 3 times with water, dried and concentrated.The residue was dissolved in methanol 500 mL.Add 100 mL to the methanol phase and stir for 20 minutes.Layered,Then the lower layer was continuously added with 100 mL of petroleum ether, stirred for another 20 min, layered, and the lower layer was concentrated, and ethyl acetate and petroleum ether were crystallized 1:10.Obtained 53 g of a white solid. Yield 78%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Xinyuan Pharmaceutical Technology Co., Ltd.; Chai Teng; Lin Zengming; (12 pag.)CN108314665; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C11H16O3

NaH (0.87 g, 80% dispersion in oil, 29.1 mmol) was washed three times with dry pentane, dried in vacuo, and then suspended in 60 mL of dry THF. A solution of 2-benzyloxymethyl-1,3-propanediol (5.70 g, 29.1 mmol) in 5 mL of THF was next added dropwise over 20 min. and the reaction mixture stirred at room temperature for 1.5 hrs. to give a white slurry. t-Butyldimethylsilylchloride (4.38 g, 29.1 mmol) was then added portionwise over 3 min. and the reaction mixture stirred at room temperature for 2 hours further. The mixture was next diluted with 150 mL of ethyl acetate and washed with 10% aqueous potassium carbonate and brine, dried over MgSO4, filtered, and concentrated to give a colorless oil. Purification by column chromatography on silica gel (ethyl acetate/hexanes) provided 7.41 g (82%) of 2-benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol as a clear, colorless liquid.

The synthetic route of 117087-18-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic; Rega Stichting v.z.w.; US5650510; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 117087-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 117087-18-0, name is 2-((Benzyloxy)methyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 3: ((3-Fluoro-2-(fluoromethyl)propoxy)methyl)benzene To a pre-cooled solution of 2-(benzyloxymethyl)propane-1,3-diol (780 mg, 3.94 mmol) in DCM (20 mL) was added DAST (1.9 g, 11.8 mmol) drop wise at -78 C. The mixture was stirred at 20 C. for 24 hours. The reaction mixture was quenched by sat. NaHCO3 aqueous (10 mL) at -78 C. DCM phase was separated and washed with brine, dried by MgSO4, filtered through a short silica gel pad and then concentrated to give the crude colorless oil (800 mg, 100%). ESI-MS (EI+, m/z): 223 [M+Na]+. 1H NMR (500 MHz, CDCl3) delta 7.37-7.28 (m, 5H), 4.65-4.57 (m, 2H), 4.55-4.48 (m, 4H), 3.57 (d, J=6.2 Hz, 2H), 2.50-2.34 (m, 1H).

According to the analysis of related databases, 117087-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Navitor Pharmaceuticals, Inc.; Fetalvero, Kristina Michelle; Narayan, Sridhar; O’Neill, David John; Saiah, Eddine; Sengupta, Shomit; (93 pag.)US2017/114080; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts