Synthetic Route of 117087-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 117087-18-0, name is 2-((Benzyloxy)methyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.
Step 3: ((3-Fluoro-2-(fluoromethyl)propoxy)methyl)benzene To a pre-cooled solution of 2-(benzyloxymethyl)propane-1,3-diol (780 mg, 3.94 mmol) in DCM (20 mL) was added DAST (1.9 g, 11.8 mmol) drop wise at -78 C. The mixture was stirred at 20 C. for 24 hours. The reaction mixture was quenched by sat. NaHCO3 aqueous (10 mL) at -78 C. DCM phase was separated and washed with brine, dried by MgSO4, filtered through a short silica gel pad and then concentrated to give the crude colorless oil (800 mg, 100%). ESI-MS (EI+, m/z): 223 [M+Na]+. 1H NMR (500 MHz, CDCl3) delta 7.37-7.28 (m, 5H), 4.65-4.57 (m, 2H), 4.55-4.48 (m, 4H), 3.57 (d, J=6.2 Hz, 2H), 2.50-2.34 (m, 1H).
According to the analysis of related databases, 117087-18-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Navitor Pharmaceuticals, Inc.; Fetalvero, Kristina Michelle; Narayan, Sridhar; O’Neill, David John; Saiah, Eddine; Sengupta, Shomit; (93 pag.)US2017/114080; (2017); A1;,
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