Category: 1013031-65-6

Synthetic Route of 1013031-65-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1013031-65-6, name is (2,6-Dibromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A Teflon reaction tube was charged with (2,6-dibromophenyl)methanol (1.00 g, 3.76 mmol) and DCM (10 mL). The solution was cooled to 00 C and DAST (0.55 mL, 4.1 mmol) was added. Themixture was stirred for 10 mm, then NaHCO3 (saturated solution, 10 mL) was added. The aqueous layer was extracted with DCM and the combined organics dried (MgSO4) and concentrated. The residue was purified by column chromatography (Si02, 0-30% EtOAc/hex) to yield 1,3-dibromo-2- (fluoromethyl)benzene.

According to the analysis of related databases, 1013031-65-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1013031-65-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1013031-65-6 as follows.

To a solution of (2,6-dibromophenyl)methanol (5 g, 18.8 mmol) in dichloromethane (50 mL) was added te^butylchlorodimethylsilane (4.25 g, 28.2 mmol) and lH-imidazole (1.91 g, 28.2 mmol) at 0 C. The reaction was stirred at ambient temperature for 16 h. Upon completion, the mixture was washed with water (3 x 100 mL), the organic layer was dried over Na2S04. The organic layer was filtered and concentrated to dryness. Purification by column chromatography (PE) gave the product (7 g, yield: 95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1013031-65-6, its application will become more common.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; BOWEN, Carrie, A.; BURDI, Douglas, F.; HEFFERNAN, Michele, L., R.; HERMAN, Lee, W.; XIE, Linghong; (266 pag.)WO2019/28165; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1013031-65-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1013031-65-6, name is (2,6-Dibromophenyl)methanol, molecular formula is C7H6Br2O, molecular weight is 265.93, as common compound, the synthetic route is as follows.

To a solution of (2,6-dibromophenyl)methanol i-Sa (9.6 g, 36.1 mmol) in DMF (100 mL) at 0 C was added NaH (60%, 2.2 g, 54 mmol) portionwise. The mixture was kept stirring at room temperature for additional 30 mins, followed by the additional of PMBC1 (8.8 g, 54 mmol). The mixture was stirred at room temperature for 2 h, quenched with sat NH4C1, and extracted with EtOAc. The combined organics were washed with brine, dried over Na2504, andconcentrated. The crude residue was purified by flash chromatography (0-10% EtOAc/hexanes)to give the title compound. ?H NMR (400 MHz, CDC13) oe 7.54 (d, J 7.9 Hz, 1H), 7.35 (d, J8.4 Hz, 1H), 7.01 (t, J= 7.9 Hz, 1H), 6.89 (d, J= 8.4 Hz, 2H), 4.81 (s, 2H), 4.58 (s, 2H), 3.81(s, 3H).

The chemical industry reduces the impact on the environment during synthesis 1013031-65-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHANG, Hongjun; BARR, Kenneth, Jay; LAPOINTE, Blair, T.; GUNAYDIN, Hakan; LIU, Kun; TROTTER, B., Wesley; (67 pag.)WO2017/75185; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts