Category: 27871-49-4

Electric Literature of 27871-49-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. A new synthetic method of this compound is introduced below.

Step 1: methyl (S)-2-((tert-butyldimethylsilyl)oxy)propanoate: a solution of methyl (2S)-2-hydroxypropanoate (5 g, 48.03 mmol, 1.00 eq.) and l H-imidazole (4.9 g, 71.98 mmol, 1.50 eq.) in dichloromethane (100 mL) was placed into a 250-mL round-bottom flask. This was followed by the addition of a solution of tert-butyl(chloro)dimethylsilane (8.69 g, 57.66 mmol, 1.20 eq.) in dichloromethane (50 mL) dropwise with stirring at 0C. The resulting solution was stirred for 2 hours at room temperature. The reaction was then quenched by the addition of 80 mL of water/ice and extracted with dichloromethane (3×50 mL). The resulting mixture was washed with brine (2×100 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 8 g (76%) of methyl (2S)-2-[(tert- butyldimethylsilyl)oxy]propanoate as a colorless liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27871-49-4, its application will become more common.

Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; BASTOS, Cecilia, M.; MUNOZ, Benito; TAIT, Bradley; (96 pag.)WO2016/105468; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C4H8O3

a solution of methyl (2S)-2-hydroxypropanoate (5 g, 48.03 mmol, 1.00 eq.) and 1H-imidazole (4.9 g, 71.98mmol, 1.50 eq.) in dichloromethane (100 mL) was placed into a 250-mL round-bottom flask. This was followed by the addition of a solution of tert-butyl(chloro)dimethylsilane (8.69 g, 57.66 mmol, 1.20 eq.) in dichloromethane (50 mL) dropwise with stirring at 0C. The resulting solution was stirred for 2 hours at room temperature. The reaction was then quenched by the addition of 80 mL of water/ice and extracted with dichloromethane (3×50 mL). The resultingmixture was washed with brine (2×100 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 8 g (76%) of methyl (2S)-2-[(tert- butyldimethylsilyl)oxy]propanoate as a colorless liquid.

With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.

Reference:
Patent; BASTOS Cecilia M.; MUNOZ Benito; TAIT Bradley; WO2015/196071; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H8O3

Under an Ar atmosphere, to a solution of methyl L-lactate (10.0 g, 96.1 mmol) in THF (100.0 mL) were added NEt3 (33.5 mL 240.2 mmol), DMAP (1.17 g, 9.6 mmol) and TBSCl (19.3 g, 128.1 mmol) at 0C, and the mixture was stirred for 24 h at r.t. The reaction mixture was diluted with Et2O, successively washed with 10% HCl aq. and sat. NaHCO3 aq., dried over MgSO4, filtered, and concentrated in vacuo. The resulting oil was purified by column chromatography on silica gel (hexane:AcOEt = 5:1) to afford the TBS ether (S-1) (20.9 g, 95.5 mmol, 99%) as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.

Reference:
Article; Sugimoto, Kenji; Kobayashi, Yuta; Hori, Ayana; Kondo, Takashi; Toyooka, Naoki; Nemoto, Hideo; Matsuya, Yuji; Tetrahedron; vol. 67; 40; (2011); p. 7681 – 7685;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 27871-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of (S)-alpha-hydroxyester 2 (1.0 equiv, 30 mmol) and 2,6-lutidine (2.3 equiv, 69 mmol) in CH2Cl2 (40 mL) at 0 C, under an atmosphere of nitrogen, was treated with triflic anhydride (1.1 equiv, 33 mmol). After 15 min, a solution of BocNHNHR’ 1 (1.0 equiv, 30 mmol) in CH2Cl2 (30 mL) was added dropwise for 30 min and the mixture was stirred for 4-6 h at 0 C until completion (monitored by TLC). After evaporation of the solvent, Et2O (50 mL) was added and 2,6-lutidinium triflate was precipitated by storing the reaction mixture overnight in the refrigerator. The 2,6-lutidinium triflate was filtered and the filtrate was diluted in Et2O (100 mL) and washed with water (20 mL), dried over MgSO4, filtered, and evaporated in vacuo. The resulting crude material was purified and characterized as reported below.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27871-49-4, (S)-Methyl 2-hydroxypropanoate.

Reference:
Article; Moussodia, Ralph-Olivier; Acherar, Samir; Bordessa, Andrea; Vanderesse, Regis; Jamart-Gregoire, Brigitte; Tetrahedron; vol. 68; 24; (2012); p. 4682 – 4692;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 27871-49-4, Adding some certain compound to certain chemical reactions, such as: 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate,molecular formula is C4H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27871-49-4.

To a solution of Intermediate Gen-14-b (694 g, 6.67 mol, 1 eq.) in DCM (7 L) under stirring and nitrogen, are added 1H-imidazole (500 g, 7.34 mol, 1.1 eq.) and Intermediate Gen-9-b (1055 g, 7.00 mol, 1.05 eq.). The reaction mixture is cooled during the addition, then stirred at room temperature overnight under nitrogen. The reaction mixture is diluted in IPE (5.5 L), the organic layer is washed once with an aqueous 1 M HCl solution (2.8 L), once with a mixture of an aqueous 1 M HCl solution and brine (1/1) (1.4 L/1.4 L) and once with brine (2.8 L), dried over Na2SO4, filtered and evaporated to dryness to give Intermediate Gen-15-b. 1H NMR (300 MHz, CDCl3-d) delta ppm 4.34 (1H, q), 3.73 (3H, s), 1.40 (3H, d), 0.91 (9H, s), 0.90 (6H, d)

According to the analysis of related databases, 27871-49-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BONNATERRE, Florence Marie-Emilie; BEAUMONT, Stephane Nicolas Alain; US2015/80391; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H8O3

Imidazole (3.39 mmol, 0.23 g) was added to the solution of (-)-methyl-L-lactate (2.16 mmol, 0.20 mL) in anhydrous CH2Cl2 (6.5 mL) at 0C. After 10 min of stirring at 0C, tert-butyldimethylsilyl chloride (2.59 mmol, 0.40 g) was added and reaction mixture was stirred at room temperature for 6 h. Then cold water (25 mL) was added and the mixture was extracted with CH2Cl2 (3×20 mL). The combined organic phases were washed with brine (20 mL), dried over Na2SO4 and concentrated to afford (S)-methyl 2-(tert-butyldimethylsilyloxy)propanoate 1a (0.46 g, 97%) as clear oil; [alpha]D23 = -27 (c 1, CHCl3); 1H NMR (CDCl3): delta = 0.07 (s, 3H), 0.10 (s, 3H), 0.90 (s, 9H), 1.40 (d, J = 6.8 Hz, 3H), 3.72 (s, 3H), 4.33 (q, J = 6.8 Hz, 1H); 13C NMR (CDCl3): delta = -5.3, -5.0, 18.3, 21.3, 25.7, 51.8, 68.4, 174.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27871-49-4, (S)-Methyl 2-hydroxypropanoate.

Reference:
Article; Sivak, Ivan; Vaclav, Jakub; Berke?, Du?an; Kolarovi?, Andrej; Tetrahedron; vol. 71; 47; (2015); p. 8871 – 8875;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 27871-49-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows.

Example: 2 Preparation of Methyl 2-(S)-methylsul?onyloxypropionate (IX) Triethylamine (107 ml) was added to a cold, stirred solution of methyl (S)- lactate (40 g) in dichloromethane (400 ml) -10C. Methanesulfonyl chloride (38.8 ml) was added to the reaction mixture drop by drop over a period of 1 h at this temperature, and the reaction mixture was stirred at this temperature for about 2 h when the reaction was complete, as indicated by TLC. The reaction mixture was poured on cold water (400 ml) and stirred for 10 minutes. The separated organic layer was washed with 5 % dilute hydrochloric acid (1 X 80 ml), saturated sodium bicarbonate solution (1 X 100 ml), brine (1 X 100 ml), dried over sodium sulfate and concentrated at 50C to furnish the desired product; 48.2 g.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27871-49-4, (S)-Methyl 2-hydroxypropanoate.

Reference:
Patent; CBZ INVESTMENTS LTD.; PRADHAN, Braja Sundar; AMARNATH, Kommireddy; VEMPALA, Naresh; RAHMAN, Md. Ataur; (42 pag.)WO2016/178162; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts