Application of 27871-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A solution of (S)-alpha-hydroxyester 2 (1.0 equiv, 30 mmol) and 2,6-lutidine (2.3 equiv, 69 mmol) in CH2Cl2 (40 mL) at 0 C, under an atmosphere of nitrogen, was treated with triflic anhydride (1.1 equiv, 33 mmol). After 15 min, a solution of BocNHNHR’ 1 (1.0 equiv, 30 mmol) in CH2Cl2 (30 mL) was added dropwise for 30 min and the mixture was stirred for 4-6 h at 0 C until completion (monitored by TLC). After evaporation of the solvent, Et2O (50 mL) was added and 2,6-lutidinium triflate was precipitated by storing the reaction mixture overnight in the refrigerator. The 2,6-lutidinium triflate was filtered and the filtrate was diluted in Et2O (100 mL) and washed with water (20 mL), dried over MgSO4, filtered, and evaporated in vacuo. The resulting crude material was purified and characterized as reported below.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27871-49-4, (S)-Methyl 2-hydroxypropanoate.
Reference:
Article; Moussodia, Ralph-Olivier; Acherar, Samir; Bordessa, Andrea; Vanderesse, Regis; Jamart-Gregoire, Brigitte; Tetrahedron; vol. 68; 24; (2012); p. 4682 – 4692;,
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