Chen, Yanhong published the artcileIdentification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1, Synthetic Route of 1379356-00-9, the publication is Bioorganic Chemistry (2018), 278-288, database is CAplus and MEDLINE.
A series of non-peptide inhibitors targeting the polo-box domain (PBD) of polo-like kinase 1 (Plk1) was designed based on the potent and selective minimal tripeptide Plk1 PBD inhibitor. Seven compounds were designed, synthesized and evaluated for fluorescence polarization (FP) assay. The most promising compound 10 bound to Plk1 PBD with IC50 of 3.37 μM and had no binding to Plk2 PBD or Plk3 PBD at 100 μM. Mol. docking study was performed and possible binding mode was proposed. MM/GBSA binding free energy calculation were in agreement with the observed exptl. results. These novel non-peptide selective Plk1 PBD inhibitors provided new lead compounds for further optimization.
Bioorganic Chemistry published new progress about 1379356-00-9. 1379356-00-9 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(3-(Aminomethyl)phenyl)ethanol, and the molecular formula is C9H13NO, Synthetic Route of 1379356-00-9.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts