Category: 3344-77-2

Adding a certain compound to certain chemical reactions, such as: 3344-77-2, 12-Bromododecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C12H25BrO, blongs to alcohols-buliding-blocks compound. COA of Formula: C12H25BrO

vi) Cholesteryl 12-hydroxydodecylcarbamate from cholesteryl chloroformate and 12-aminododecan-1-ol. 12-Aminododecanl-1-ol is prepared from 12-bromododecan-1-ol and sodium azide in refluxing 95% ethanol, followed by catalytic hydrogenation (10% Pd/C catalyst, 30 psi hydrogen) in methanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3344-77-2, 12-Bromododecan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Dharmacon, Inc.; US2008/85869; (2008); A1;,
Alcohol – Wikipedia,
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Electric Literature of 3344-77-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, molecular weight is 265.23, as common compound, the synthetic route is as follows.

To a solution of S1 (680 mg, 2.58 mmol) in CH2Cl2 (4.6 mL) were added 3,4-dihydro-2H-pyran (0.35 mL, 3.89 mmol) and pyridinium p-toluene sulfonate (6.59 mg, 26.2 mumol). The reaction mixture was stirred at room temperature for 4 h and then diluted with CH2Cl2. The resulting mixture was washed with sat. NaHCO3 and brine, dried over MgSO4, and evaporated. The resulting residue was purified by column chromatography (SiO2, hexane:EtOAc 30/1) to furnish S2 (763 mg, 85percent) as a colorless oil

Statistics shows that 3344-77-2 is playing an increasingly important role. we look forward to future research findings about 12-Bromododecan-1-ol.

Reference:
Article; Takagi, Ryukichi; Igata, Nao; Yamamoto, Kazuhiro; Kojima, Satoshi; Journal of Organometallic Chemistry; vol. 696; 8; (2011); p. 1556 – 1564;,
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Synthetic Route of 3344-77-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, molecular weight is 265.23, as common compound, the synthetic route is as follows.

Example 2 Preparation of (12-bromododecyloxy)(tert-butyl)dimethylsilane (4) Tert-butyldimethylsilyl chloride (5.61 g; 37.3 mmol; 1.5 eq.) and imidazole (2.54 g; 37.3 mmol; 1.5 eq.) are added to a solution of 12-bromododecan-1-ol (6.6 g; 24.9 mmol; 1 eq.) in dichloromethane (60 ml) at room temperature. After 4 h, the reaction mixture is poured into a saturated solution of NH4Cl (100 ml) and then extracted with ether (3*100 ml). The organic phase is washed with a saturated solution of NaCl, dried on MgSO4, filtered then evaporated. The crude reaction product is purified by silica gel chromatography (eluent: hexane-AcOEt: 95-5) to yield 9.17 g of a colorless oil. Yield: 99percent Empirical formula: C18H39BrOSi

Statistics shows that 3344-77-2 is playing an increasingly important role. we look forward to future research findings about 12-Bromododecan-1-ol.

Reference:
Patent; Centre National de la Recherche Scientifique(CNRS); Universite de Luxembourg; US2010/48731; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3344-77-2, name is 12-Bromododecan-1-ol. A new synthetic method of this compound is introduced below., Safety of 12-Bromododecan-1-ol

Tetrahydro-2-(12-bromododecanoxy)-2H pyran To a solution of 12-bromo-1-dodecanol (1 mole) in dichloromethane containing pyridinium p-toluenesulfonate (P-TSA) is added dihydropyran (2 moles). The reaction mixture is stirred for 24 hours and then washed twice with water and dried over anhydrous MgSO4. The dichloromethane is removed under reduced pressure. If necessary the resulting product is purified by chromatography on silica gel. Coupling of polyethylene glycol to the terahydropyran derivative The tetrahydropyran derivative described above, dissolved in dry benzene, is added to a solution of polyethylene glycol (1 mole) in dry benzene containing NaH (1 mole).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3344-77-2, 12-Bromododecan-1-ol.

Reference:
Patent; Protein Delivery, Inc.; US6191105; (2001); B1;; ; Patent; Protein Delivery, Inc.; US5681811; (1997); A;,
Alcohol – Wikipedia,
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Related Products of 3344-77-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, molecular weight is 265.23, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of the 1,12-dodecanediol (5) (1.00 equiv) in30 mL of toluene HBr 48% (2.00 equiv) was added. The reaction wasstirred at 110C for 24 h. The solvent was removed under reducedpressure, and the residue was purified by column chromatographyover silica gel, eluting with hexane/EtOAc 9:1, to yield pure haloalcohol (6). This compound was transformed into their corresponding azidoalcohol (7) via classic SN2 substitution. A stock solution of 0.5 M NaN3in DMSO was prepared by stirring the solutionfor 24 h at room temperature. To a 100 mL round-bottom flaskequipped with a magnetic stir bar was added a 0.5 M solution ofNaN3in DMSO at room temperature. To this solution was added thebromo alcohol (6) (1.00 equiv) and the mixture was stirred for 24 hat room temperature. The reaction was quenched with H2O (50 mL)and stirred until it cooled to room temperature. The mixture wasextracted with Et2O(330 mL), and the resultant extracts werewashed with H2O(350 mL) and brine (50 mL). The organic layerwas dried (Na2SO4) and filtered, and the residue obtained waspurified by column chromatography over silica gel, eluting withhexane/EtOAc 9:1, to yield pure alkyl azidoalcohol (7).

The chemical industry reduces the impact on the environment during synthesis 3344-77-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Gontijo, Vanessa Silva; Espuri, Patricia Ferreira; Alves, Rosemeire Brondi; De Camargos, Luiz Fernando; Dos Santos, Fabio Vieira; De Souza Judice, Wagner Alves; Marques, Marcos Jose; Freitas, Rossimiriam Pereira; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 24 – 33;,
Alcohol – Wikipedia,
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Reference of 3344-77-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) 2-(12-Bromododecyloxy)tetrahydropyran 12-Bromo-dodecan-1-ol (5.12 g, 19.3 mmol) was added to a vigorously stirred solution of dihydropyran (2.1 mL, 23.2 mmol) and Amberlyst HI5 (0.25 g, Aldrich D10,620-8) in hexane (100 mL). After 3 hours dihydropyran (2.1 mL) was added and the solution stirred for a further 15 hours. The mixture was then filtered, and the filtrate concentrated in vacuo and chromatographed graphed on silica gel, eluding with 2percent ethyl acetate in hexane to give the title compound, (a), 8.02 g (75percent), as an oil.

According to the analysis of related databases, 3344-77-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Warner-Lambert Company; US5073565; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts