Application of 123206-83-7, Adding some certain compound to certain chemical reactions, such as: 123206-83-7, name is 4-(2-Bromophenyl)butan-1-ol,molecular formula is C10H13BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123206-83-7.
Step C: To a solution of 4-(o-bromophenyl)-1-butanol (1.222 g, ca 0.0053 mol) and tetrakis(triphenylphosphine) palladium (0) (650 mg, 0.562 mmol) in 1,2-dimethoxyethane (55 mL) was added thiophene-2-boronic acid (2.057 g, 0.016 mol) and 1 N aqueous NaHCO3 (15 mL). The resulting mixture was heated at reflux under nitrogen atmosphere for 3 days. The dark reaction mixture was diluted with water (50 mL) and extracted with EtOAc (100 mL). The organic layer was dried over Na2SO4, filtered through a bed of Celite and concentrated to yield a crude which was purified by flash chromatography (30% EtOAc in hexane) to yield 4-(2-thien-2-yl-phenyl)-butan-1-ol as a light brown oil. 1H NMR (300 MHz, DMSO d6) delta ??1.37-1.56 (m, 4H), 2.66-2.71 (m, 2H), 3.31-3.35 (m, 2H), 4.33 (br s, 1 H), 7.10-7.15 (m, 2H), 7.21-7.26 (m, 1 H), 7.31-7.34 (m, 3H), 7.59-7.61 (m, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123206-83-7, 4-(2-Bromophenyl)butan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Janssen Pharmaceuticals, Inc.; JORDAN, Alfonzo; PAN, Kevin; REITZ, Allen, B.; (71 pag.)EP1392687; (2017); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts